NOAEL Studies
Cosmetic Ingredient
Benzotriazole NOAEL Studies
INCI: BENZOTRIAZOLE
CAS: 95-14-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >200 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6z; document=edcd9de9-5f02-425d-befa-6b6c5ea99e55_481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6d; document_key=edcd9de9-5f02-425d-befa-6b6c5ea99e55/481ec3c8-bfbb-4e68-9033-77a8586dc6ec; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2012; basis=other:; key_result=true; entry_uuid=7e083db5-2096-4683-b501-d9c45b40a6bf |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 36 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6z; document=81c53c01-8586-4464-8827-adaf63aabc3b_481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6d; document_key=81c53c01-8586-4464-8827-adaf63aabc3b/481ec3c8-bfbb-4e68-9033-77a8586dc6ec; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-04-10; basis=clinical signs; key_result=true; entry_uuid=f2a65db0-ce75-48e6-8204-483eef5fc07b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 120 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6z; document=81c53c01-8586-4464-8827-adaf63aabc3b_481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6d; document_key=81c53c01-8586-4464-8827-adaf63aabc3b/481ec3c8-bfbb-4e68-9033-77a8586dc6ec; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-04-10; basis=fetal/pup body weight changes; key_result=true; entry_uuid=4626d14b-f18c-4ac4-b8b3-406ee852d7b5 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >200 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6z; document=edcd9de9-5f02-425d-befa-6b6c5ea99e55_481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6d; document_key=edcd9de9-5f02-425d-befa-6b6c5ea99e55/481ec3c8-bfbb-4e68-9033-77a8586dc6ec; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2012; basis=other:; key_result=true; entry_uuid=7e083db5-2096-4683-b501-d9c45b40a6bf |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 36 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6z; document=81c53c01-8586-4464-8827-adaf63aabc3b_481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6d; document_key=81c53c01-8586-4464-8827-adaf63aabc3b/481ec3c8-bfbb-4e68-9033-77a8586dc6ec; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-04-10; basis=clinical signs; key_result=true; entry_uuid=f2a65db0-ce75-48e6-8204-483eef5fc07b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 120 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6z; document=81c53c01-8586-4464-8827-adaf63aabc3b_481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6d; document_key=81c53c01-8586-4464-8827-adaf63aabc3b/481ec3c8-bfbb-4e68-9033-77a8586dc6ec; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-04-10; basis=fetal/pup body weight changes; key_result=true; entry_uuid=4626d14b-f18c-4ac4-b8b3-406ee852d7b5 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >200 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6z; document=edcd9de9-5f02-425d-befa-6b6c5ea99e55_481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6d; document_key=edcd9de9-5f02-425d-befa-6b6c5ea99e55/481ec3c8-bfbb-4e68-9033-77a8586dc6ec; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2012; basis=other:; key_result=true; entry_uuid=7e083db5-2096-4683-b501-d9c45b40a6bf |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 36 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6z; document=81c53c01-8586-4464-8827-adaf63aabc3b_481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6d; document_key=81c53c01-8586-4464-8827-adaf63aabc3b/481ec3c8-bfbb-4e68-9033-77a8586dc6ec; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-04-10; basis=clinical signs; key_result=true; entry_uuid=f2a65db0-ce75-48e6-8204-483eef5fc07b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 120 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6z; document=81c53c01-8586-4464-8827-adaf63aabc3b_481ec3c8-bfbb-4e68-9033-77a8586dc6ec.i6d; document_key=81c53c01-8586-4464-8827-adaf63aabc3b/481ec3c8-bfbb-4e68-9033-77a8586dc6ec; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-04-10; basis=fetal/pup body weight changes; key_result=true; entry_uuid=4626d14b-f18c-4ac4-b8b3-406ee852d7b5 |
INCHEM_WHO_kemi_kemi_ah2000_24 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_kemi_kemi_ah2000_24 | LOAEL | =1455 | mg/kg bw | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_24; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and The Dutch Expert Committee on Occupational Standards. 126. 1,2,3-Benzotriazole; path=mirror/documents/kemi/kemi/ah2000_24.pdf; row_hash=4db96f9ef93640f1; raw_unit=mg/kg; context=LOAEL-värdena var 295 och 1455 mg/kg kroppsvikt/dag hos råtta respektive mus. |
| INCHEM_WHO_kemi_kemi_ah2000_24 | LOAEL | =1455 | mg/kg bw | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_24; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and The Dutch Expert Committee on Occupational Standards. 126. 1,2,3-Benzotriazole; path=mirror/documents/kemi/kemi/ah2000_24.pdf; row_hash=4db96f9ef93640f1; raw_unit=mg/kg; context=LOAEL-värdena var 295 och 1455 mg/kg kroppsvikt/dag hos råtta respektive mus. |
| INCHEM_WHO_kemi_kemi_ah2000_24 | LOAEL | =1455 | mg/kg bw | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_24; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and The Dutch Expert Committee on Occupational Standards. 126. 1,2,3-Benzotriazole; path=mirror/documents/kemi/kemi/ah2000_24.pdf; row_hash=4db96f9ef93640f1; raw_unit=mg/kg; context=LOAEL-värdena var 295 och 1455 mg/kg kroppsvikt/dag hos råtta respektive mus. |
| INCHEM_WHO_kemi_kemi_ah2000_24 | LOAEL | =1455 | mg/kg bw | - | - | - | Toxicology study | document_id=kemi_kemi_ah2000_24; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and The Dutch Expert Committee on Occupational Standards. 126. 1,2,3-Benzotriazole; path=mirror/documents/kemi/kemi/ah2000_24.pdf; row_hash=4db96f9ef93640f1; raw_unit=mg/kg; context=LOAEL-värdena var 295 och 1455 mg/kg kroppsvikt/dag hos råtta respektive mus. |
NTP_ICE_acute_inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 1.91 | mg/L | - | Inhalation | Duration=3 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3269; Record_ID=acute_inhalation_2673; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6020147; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.91; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020147; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020147 |
NTP_ICE_acute_oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_11679; row=9908; data_type=In Vivo; mixture=Chemical; chemical_name=1,2,3-Benzotriazole; preferred_name=1,2,3-Benzotriazole; dtxsid=DTXSID6020147; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020147; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020147; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =560 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_11680; row=9907; data_type=In Vivo; mixture=Chemical; chemical_name=1,2,3-Benzotriazole; preferred_name=1,2,3-Benzotriazole; dtxsid=DTXSID6020147; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020147; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020147; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =600 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11681; row=9906; data_type=In Vivo; mixture=Chemical; chemical_name=1,2,3-Benzotriazole; preferred_name=1,2,3-Benzotriazole; dtxsid=DTXSID6020147; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020147; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020147; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 0 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=2308; Record_ID=adme_parameters_804; Data_Type=Measured; DTXSID=DTXSID6020147; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020147; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020147 |
| NTP_ICE_adme_parameters | Fu | 0.287 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=2307; Record_ID=adme_parameters_804; Data_Type=Measured; DTXSID=DTXSID6020147; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.287; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020147; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020147 |
NTP_ICE_cancer 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | Top dose | 2350 | ppm | Mouse | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=6299; Record_ID=cancer_5065; Data_Type=In Vivo; Formulation_Name=1,2,3-Benzotriazole; Mixture=Chemical; DTXSID=DTXSID6020147; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=2350; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Female; Reference=TR-088; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr088/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020147; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020147 |
| NTP_ICE_cancer | Top dose | 12100 | ppm | Rat | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=6298; Record_ID=cancer_5063; Data_Type=In Vivo; Formulation_Name=1,2,3-Benzotriazole; Mixture=Chemical; DTXSID=DTXSID6020147; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=12100; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Reference=TR-088; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr088/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020147; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020147 |
| NTP_ICE_cancer | Top dose | 23500 | ppm | Mouse | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=6300; Record_ID=cancer_5064; Data_Type=In Vivo; Formulation_Name=1,2,3-Benzotriazole; Mixture=Chemical; DTXSID=DTXSID6020147; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=23500; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Reference=TR-088; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr088/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020147; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020147 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=356; RecordID=ARPathway2016_1755; DatasetName=ARPathway2016; DTXSID=DTXSID6020147; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020147; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020147 |
ToxRefDB_ToxRefDB_v3_pod.csv 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =335 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 105 week | CHR | study_id=1366; toxval_study_source_id=studyid1366_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-pituitary gland-adenoma|pathology microscopic-adrenal gland-pheochromocytoma nos|in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-kidney-nephropathy|pathology microscopic-uterus-inflammation|pathology microscopic-liver-basophilic focus|pathology microscopic-kidney-hyperplasia; dose_level=1; study_year=1978; study_citation=NTP_1978_Bioassay of 1H-Benzotriazole For Possible Carcinogenicity_rat_TR-88; dsstox_substance_id=DTXSID6020147; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =1755 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 106 week | CHR | study_id=1367; toxval_study_source_id=studyid1367_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-uterus-hyperplasia|pathology microscopic-blood-lymphoma nos|in life observation-body weight-body weight; dose_level=1; study_year=1978; study_citation=NTP_1978_Bioassay of 1H-Benzotriazole for Possible Carcinogenicity_mouse_TR-88; dsstox_substance_id=DTXSID6020147; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 105 week | CHR | study_id=1366; toxval_study_source_id=studyid1366_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-kidney-nephropathy|pathology microscopic-kidney-hyperplasia|pathology microscopic-liver-basophilic focus|pathology microscopic-uterus-inflammation|pathology microscopic-pituitary gland-adenoma|pathology microscopic-adrenal gland-pheochromocytoma nos; dose_level=0; study_year=1978; study_citation=NTP_1978_Bioassay of 1H-Benzotriazole For Possible Carcinogenicity_rat_TR-88; dsstox_substance_id=DTXSID6020147; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =4.2 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630042:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_740dc82bc83147f28c38a95c52ebbe59 |
ToxValDB_HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HESS | NOEL | <30 | mg/kg bw/day | Rat | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e16e4b0a676289df6b3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Blood Chemistry: AST increase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=HESS:15638120:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_639c2287bad5d606458a85c6a02223d6 |
ToxValDB_ToxRefDB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =335 | mg/kg bw/day | Rat | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_1978_Bioassay of 1H-Benzotriazole For Possible Carcinogenicity_rat_TR-88; TITLE=Bioassay of 1H-Benzotriazole For Possible Carcinogenicity_rat; AUTHOR=NTP; EXTERNAL_SOURCE_ID=1366; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-pituitary gland-adenoma|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-uterus-inflammation|systemic: pathology microscopic-liver-basophilic focus|systemic: pathology microscopic-adrenal gland-pheochromocytoma nos|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-kidney-nephropathy|systemic: pathology microscopic-kidney-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15686907_15686908:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af44d2c54faa47c7334554b8806c195f |
| ToxValDB_ToxRefDB | LEL | =1755 | mg/kg bw/day | Mouse | oral | chronic; 106 weeks | chronic | LONG_REF=NTP_1978_Bioassay of 1H-Benzotriazole for Possible Carcinogenicity_mouse_TR-88; TITLE=Bioassay of 1H-Benzotriazole for Possible Carcinogenicity_mouse; AUTHOR=NTP; EXTERNAL_SOURCE_ID=1367; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-uterus-hyperplasia|systemic: pathology microscopic-blood-lymphoma nos|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15686911_15686912:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_567646c42da2171a2bd76c04cf2d0ba9 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 86110UXM5Y | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H5N3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"86110UXM5Y"} |
| openFDA substances | FDA UNII substance identifier | 86110UXM5Y | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H5N3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"86110UXM5Y"} |
| openFDA substances | FDA UNII substance identifier | 86110UXM5Y | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H5N3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"86110UXM5Y"} |
| openFDA substances | FDA UNII substance identifier | 86110UXM5Y | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H5N3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"86110UXM5Y"} |