NOAEL Studies Cosmetic Ingredient

Benzyl Dimethylamino Morpholinophenyl Butanone NOAEL Studies

INCI: BENZYL DIMETHYLAMINO MORPHOLINOPHENYL BUTANONE

CAS: 119313-12-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL >=250 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1d50; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/6517?documentUUID=2e1c5732-812d-4d5e-8b86-f3ab451310a4; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|food consumption and compound intake|gross pathology|haematology|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|gross pathology|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847418_15849000_15849114:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ecfa7c4d87dc61f922836b66d9a0e13d
ToxValDB_ECHA_IUCLID LOAEL <=500 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1d50; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/6517?documentUUID=2e1c5732-812d-4d5e-8b86-f3ab451310a4; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|food consumption and compound intake|gross pathology|haematology|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|gross pathology|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847418_15849000_15849114:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fc7a5f1ae158758bac742be81f0606bf
ToxValDB_ECHA_IUCLID NOAEL =100 mg/kg bw/day Rat oral chronic; 127 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1d46; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/6517?documentUUID=2e1c5732-812d-4d5e-8b86-f3ab451310a4; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15847243:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_55f666d0dc9d8d9204677a1133f786dc
ToxValDB_ECHA_IUCLID NOAEL =50 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1d4e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/6517?documentUUID=c6069c8d-95cd-46ed-bebe-9756bd8845b9; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15850483:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2c10cb8d9d6855377026bab1ca6deb95
ToxValDB_ECHA_IUCLID NOEL =10 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1d4a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/6517?documentUUID=2e1c5732-812d-4d5e-8b86-f3ab451310a4; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835432_15850482:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_63e206c4534ce57493192b8107d73065
ToxValDB_GESTIS_DNEL 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =2.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630066_15630067_15630068:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_996c95907dcbaac299b8c6ef3936f337
ToxValDB_GESTIS_DNEL DNEL systemic =1.175 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630066_15630067_15630068:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c7a90f516087344f7f35d19ec74a972b
ToxValDB_GESTIS_DNEL DNEL systemic =0.82 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630066_15630067_15630068:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4db1aad3b5c926e30be2ec036be76052
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 413O6RKS6B UNII - - - chemical {"approval_status":null,"molecular_formula":"C23H30N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"413O6RKS6B"}
openFDA substances FDA UNII substance identifier 413O6RKS6B UNII - - - chemical {"approval_status":null,"molecular_formula":"C23H30N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"413O6RKS6B"}
openFDA substances FDA UNII substance identifier 413O6RKS6B UNII - - - chemical {"approval_status":null,"molecular_formula":"C23H30N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"413O6RKS6B"}
openFDA substances FDA UNII substance identifier 413O6RKS6B UNII - - - chemical {"approval_status":null,"molecular_formula":"C23H30N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"413O6RKS6B"}