Moderate Cosmetic Ingredient NOAEL Data

Benzyl Dimethylamino Morpholinophenyl Butanone

Also known as: 1-Butanone, 2-(dimethylamino)-1-[4-(4-morpholinyl)phenyl]-2-(phenylmethyl)-

INCI: BENZYL DIMETHYLAMINO MORPHOLINOPHENYL BUTANONE

Benzyl Dimethylamino Morpholinophenyl Butanone (CAS 119313-12-1) is a cosmetic cosmetic ingredient functioning as Photoinitiator (UV nail gel curing systems). NOAEL 100 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 119313-12-1 →

Auto-generated CPSR Part A draft with source citations
Function
Photoinitiator (UV nail gel curing systems)
Safety Rating
MODERATE

Chemistry & Identifiers

EC Number
404-360-3

Regulatory Status

EU EU Status prohibited
US US Status permitted
US Notes Not specifically regulated for cosmetic use; industrial/technical-grade chemical

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Benzyl Dimethylamino Morpholinophenyl Butanone.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Benzyl Dimethylamino Morpholinophenyl Butanone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =50 mg/kg bw/day oral Rat short-term ToxValDB_ECHA_IUCLID
NOAEL =100 mg/kg bw/day oral Rat chronic ToxValDB_ECHA_IUCLID

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Benzyl Dimethylamino Morpholinophenyl Butanone across SCCS product categories, with measured dermal absorption where available.

EU CLP Annex VI Harmonized Classification

Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.

Signal Word
Danger
Pictograms
Health HazardEnvironmental Hazard
Hazard Class and Category
Repr. 1B; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
  • H360D
  • H400 Very toxic to aquatic life
  • H410 Very toxic to aquatic life with long lasting effects

Inserted via ATP: ATP14

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
Yes (since 16-Jan-2020)
Hazard classification: Restricted (Annex XVII)
SVHC reason: Toxic for reproduction (Article 57c)
Substance of Very High Concern (SVHC)
Included: 16-Jan-2020
Toxic for reproduction (Article 57c)

EU CosIng Annex Listing

European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.

Annex II — Prohibited
Ref: 1614
(EU) 2019/1966
CMR: Reprotoxic Cat. 1B()

Expanded Jurisdictional Detail

Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.

SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1614
BRIN Brazil/India Cosmetics
India: Prohibited (GNRAS)

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Binder Catalyst Photosensitizers UV stabilizer
Regulatory List Membership (2)
EU Banned in Cosmetics EU CosIng Cosmetics Ingredient Database

Expert Verdict

Expert safety assessment and concern-level summary for Benzyl Dimethylamino Morpholinophenyl Butanone.

Regulatory Flags

potential-allergen eu_banned_cosmetics eu_cosing_listed

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Benzyl Dimethylamino Morpholinophenyl Butanone by CAS number or substance name.

Studies
2
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
100 mg/kg bw/day
ToxValDB_ECHA_IUCLID

Known Synonyms

1-Butanone, 2-(dimethylamino)-1-[4-(4-morpholinyl)phenyl]-2-(phenylmethyl)-

Chemical Function

Binder Photosensitizers UV stabilizer Catalyst

Regulatory Lists

banned; Europe; Personal care

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

ChEMBL ID
CHEMBL3187611
View full pharmaceutical profile →

Frequently Asked Questions

Is Benzyl Dimethylamino Morpholinophenyl Butanone safe in cosmetics?

Benzyl Dimethylamino Morpholinophenyl Butanone has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 2 toxicological study endpoint(s) are available in our database.

Is Benzyl Dimethylamino Morpholinophenyl Butanone allowed in the EU?

Benzyl Dimethylamino Morpholinophenyl Butanone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Benzyl Dimethylamino Morpholinophenyl Butanone do in cosmetics?

Benzyl Dimethylamino Morpholinophenyl Butanone functions as: Photoinitiator (UV nail gel curing systems). It is classified as a cosmetic ingredient in our database. CAS number: 119313-12-1.

What is the NOAEL for Benzyl Dimethylamino Morpholinophenyl Butanone?

The NOAEL (No Observed Adverse Effect Level) for Benzyl Dimethylamino Morpholinophenyl Butanone is =50 mg/kg bw/day based on a short-term study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.

Is Benzyl Dimethylamino Morpholinophenyl Butanone used outside cosmetics?

Benzyl Dimethylamino Morpholinophenyl Butanone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Benzyl Dimethylamino Morpholinophenyl Butanone have different safety status in cosmetics vs industrial chemicals?

Benzyl Dimethylamino Morpholinophenyl Butanone is prohibited in EU cosmetics but has active industrial GHS classifications (H360, H360D, H400, H410).

Is Benzyl Dimethylamino Morpholinophenyl Butanone in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Benzyl Dimethylamino Morpholinophenyl Butanone in your formulation.