Benzyl Dimethylamino Morpholinophenyl Butanone (CAS 119313-12-1) is a cosmetic cosmetic ingredient functioning as Photoinitiator (UV nail gel curing systems). NOAEL 100 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
US NotesNot specifically regulated for cosmetic use; industrial/technical-grade chemical
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Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Benzyl Dimethylamino Morpholinophenyl Butanone.
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Toxicological Studies
2 study endpoints found for Benzyl Dimethylamino Morpholinophenyl Butanone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=50 mg/kg bw/day
oral
Rat
short-term
ToxValDB_ECHA_IUCLID
NOAEL
=100 mg/kg bw/day
oral
Rat
chronic
ToxValDB_ECHA_IUCLID
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Benzyl Dimethylamino Morpholinophenyl Butanone across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health HazardEnvironmental Hazard
Hazard Class and Category
Repr. 1B; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
H360D
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
Inserted via ATP: ATP14
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
Yes (since 16-Jan-2020)
Hazard classification:Restricted (Annex XVII)
SVHC reason:Toxic for reproduction (Article 57c)
Substance of Very High Concern (SVHC)
Included: 16-Jan-2020
Toxic for reproduction (Article 57c)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1614
(EU) 2019/1966
CMR:Reprotoxic Cat. 1B()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1614
BRIN Brazil/India Cosmetics
India: Prohibited (GNRAS)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
BinderCatalystPhotosensitizersUV stabilizer
Regulatory List Membership (2)
EU Banned in CosmeticsEU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Benzyl Dimethylamino Morpholinophenyl Butanone.
Is Benzyl Dimethylamino Morpholinophenyl Butanone safe in cosmetics?
Benzyl Dimethylamino Morpholinophenyl Butanone has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Is Benzyl Dimethylamino Morpholinophenyl Butanone allowed in the EU?
Benzyl Dimethylamino Morpholinophenyl Butanone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Benzyl Dimethylamino Morpholinophenyl Butanone do in cosmetics?
Benzyl Dimethylamino Morpholinophenyl Butanone functions as: Photoinitiator (UV nail gel curing systems). It is classified as a cosmetic ingredient in our database. CAS number: 119313-12-1.
What is the NOAEL for Benzyl Dimethylamino Morpholinophenyl Butanone?
The NOAEL (No Observed Adverse Effect Level) for Benzyl Dimethylamino Morpholinophenyl Butanone is =50 mg/kg bw/day based on a short-term study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Benzyl Dimethylamino Morpholinophenyl Butanone used outside cosmetics?
Benzyl Dimethylamino Morpholinophenyl Butanone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Benzyl Dimethylamino Morpholinophenyl Butanone have different safety status in cosmetics vs industrial chemicals?
Benzyl Dimethylamino Morpholinophenyl Butanone is prohibited in EU cosmetics but has active industrial GHS classifications (H360, H360D, H400, H410).
Compliance Tools
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