NOAEL Studies Cosmetic Ingredient

Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine NOAEL Studies

INCI: BIS-(DIETHYLAMINOHYDROXYBENZOYL BENZOYL) PIPERAZINE

CAS: 919803-06-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =100 % - oral 13 week NOAEL study p.67
SCCS Opinion NOAEL =299 - - - 5 days repeated dose toxicity p.42
SCCS Opinion NOAEL =1000 mg/kg/day rat oral 13 weeks genotoxicity p.33
SCCS Opinion NOAEL =1000 mg/kg bw/day rat - developmental developmental toxicity p.39
SCCS Opinion NOAEL =1000 mg/kg bw/d rat oral - repeated dose toxicity p.63
SCCS Opinion NOAEL =1000 mg/kg rat - 45 days repeated dose toxicity p.41
Regulatory source 17 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 100 % - oral 13 week - p.67
Regulatory source developmental toxicity 1000 mg/kg bw/day rat - developmental developmental toxicity p.39
Regulatory source genotoxicity 1000 mg/kg/day rat oral 13 weeks genotoxicity p.33
Regulatory source genotoxicity 1000 mg/kg bw/d rat oral - genotoxicity p.67
Regulatory source irritation 1000 mg/kg bw/day rat oral - irritation p.53
Regulatory source repeated dose toxicity 299 - - - 5 days repeated dose toxicity p.42
Regulatory source repeated dose toxicity 1000 mg/kg bw/d rat oral - repeated dose toxicity p.63
Regulatory source repeated dose toxicity 1000 mg/kg bw/day rat oral Subchronic repeated dose toxicity p.64
Regulatory source repeated dose toxicity 1000 mg/kg rat - 45 days repeated dose toxicity p.41
Regulatory source repeated dose toxicity 1000 mg/kg rat oral 45 days repeated dose toxicity p.41
Regulatory source repeated dose toxicity 1000 mg/kg - - chronic repeated dose toxicity p.41
Regulatory source repeated dose toxicity 1000 mg/kg - - Sub-chronic repeated dose toxicity p.55
Regulatory source reproductive toxicity 1000 mg/kg bw/day rat - - reproductive toxicity p.62
Regulatory source reproductive toxicity 1000 - rat - - reproductive toxicity p.62
Regulatory source reproductive toxicity 1000 mg/kg bw/day rat oral developmental reproductive toxicity p.65
Regulatory source reproductive toxicity 1000 mg/kg bw/day rat oral 15 days reproductive toxicity p.65
Regulatory source reproductive toxicity 1000 mg/kg/day - oral - reproductive toxicity p.3