INCI: BIS-(DIETHYLAMINOHYDROXYBENZOYL BENZOYL) PIPERAZINE
Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine (CAS 919803-06-8) is a cosmetic cosmetic ingredient functioning as UV filter (UVA absorber). Reported NOAEL =1000 mg/kg/day in rat (SCCS Opinion); EU Regulation 1223/2009 status: restricted, max 10%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 919803-06-8 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine.
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10 study endpoints found for Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg/day | oral | rat | genotoxicity | SCCS Opinion |
| NOAEL | =1000 mg/kg bw/day | - | rat | developmental toxicity | SCCS Opinion |
| NOAEL | =1000 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =1000 mg/kg | - | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =1000 mg/kg/day | oral | rat | genotoxicity | SCCS Opinion |
| NOAEL | =1000 mg/kg bw/day | - | rat | developmental toxicity | SCCS Opinion |
| NOAEL | =1000 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =1000 mg/kg/day | oral | rat | genotoxicity | SCCS Opinion |
| NOAEL | =1000 mg/kg bw/day | - | rat | developmental toxicity | SCCS Opinion |
| NOAEL | =1000 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS Opinion |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_uv_filter | 10% | - |
| ASEAN | permitted_uv_filter | 10% | - |
| VN | permitted_uv_filter | 10% | All products |
| VN | permitted_uv_filter | 10% | Non-inhalation applications only |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.5% | in_vitro | - | SCCS/0256 |
| measured | 0.03% | - | - | SCCS/0256 |
| measured | 99.0% | - | - | SCCS/0256 |
| measured | 0.01% | - | - | SCCS/0256 |
| measured | 0.52% | - | - | SCCS/0256 |
Preliminary editorial summary for Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine by CAS number or substance name.
Units vary across source rows: mg/kg/day, mg/kg bw/day, mg/kg bw/d
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.5% | in_vitro | - |
| 0.03% | - | - |
| 99.0% | - | - |
| 0.01% | - | - |
| 0.52% | - | - |
Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine EU regulatory status: restricted. Maximum allowed concentration: 10%. This is based on EU Regulation 1223/2009 and its amendments.
Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine functions as: UV filter (UVA absorber). It is classified as a cosmetic ingredient in our database. CAS number: 919803-06-8.
The NOAEL (No Observed Adverse Effect Level) for Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine is =1000 mg/kg/day based on a genotoxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS Opinion.
Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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