Moderate Cosmetic Ingredient

Bis-Glyoxyloyl Cystine

INCI: BIS-GLYOXYLOYL CYSTINE

CAS Number
Not publicly assigned in CosIng
Function
Hair conditioning (hair straightening/smoothing active)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status restricted
US Notes No individual CIR review. FDA has not specifically restricted. Subject to state-level formaldehyde exposure regulations.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Glyoxylic acid derivatives release formaldehyde when heated and convert to oxalate in peroxisomes, linked to acute kidney injury in case reports. Hair damage documented including reduced breakage resistance, mass loss, and color changes. Brazilian ANVISA and several EU Member States actively scrutinizing this class; air monitoring during salon application recommended. Not suitable for COSMOS/ECOCERT certification.

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Concern Level: High

Frequently Asked Questions

Is Bis-Glyoxyloyl Cystine safe in cosmetics?

Glyoxylic acid derivatives release formaldehyde when heated and convert to oxalate in peroxisomes, linked to acute kidney injury in case reports. Hair damage documented including reduced breakage resistance, mass loss, and color changes. Brazilian ANVISA and several EU Member States actively scrutinizing this class; air monitoring during salon application recommended. Not suitable for COSMOS/ECOCERT certification. The EU classifies Bis-Glyoxyloyl Cystine as "restricted". Safety rating: MODERATE.

Is Bis-Glyoxyloyl Cystine allowed in the EU?

Bis-Glyoxyloyl Cystine EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Bis-Glyoxyloyl Cystine do in cosmetics?

Bis-Glyoxyloyl Cystine functions as: Hair conditioning (hair straightening/smoothing active). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned in CosIng.

What is the Margin of Safety for Bis-Glyoxyloyl Cystine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Bis-Glyoxyloyl Cystine compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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