NOAEL Studies Cosmetic Ingredient

BIS-METHANE NOAEL Studies

CAS: 474510-57-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_6605; row=8032; data_type=In Vivo; mixture=Chemical; chemical_name=1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one); preferred_name=1,1'-[Methylenedi(4,1-phenylene)]bis(2-hydroxy-2-methylpropan-1-one); dtxsid=DTXSID40621591; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID40621591; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL <200 mg/kg bw/day Rat oral short-term; 5 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb41e4b0a7c65d2255d7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5067/7/6/2?documentUUID=b6d6bfaf-0bee-45b7-af0c-7143d8fe7162; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835577_15843578_15846833_15846834_15846899_15846900:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_434b3226e70f0e1bb16fee1d00c7c709
ToxValDB_ECHA_IUCLID LEL <100 mg/kg bw/day Rat oral short-term; 5 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb41e4b0a7c65d2255cb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5067/7/6/2?documentUUID=5a96a5f0-fa17-40ff-940f-dd731c3671ea; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835577_15843578_15846833_15846834_15846899_15846900:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7df9dbfb7be294e7e7aafca7362acc4f
ToxValDB_ECHA_IUCLID NOAEL =5 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae4de4b0a7c65d1c87a2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5067/7/6/2?documentUUID=b6d6bfaf-0bee-45b7-af0c-7143d8fe7162; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830425_15839192:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0544768ca05d3699c0d00692fbed4004
ToxValDB_ECHA_IUCLID NOAEL =30 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae4de4b0a7c65d1c87a5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5067/7/6/2?documentUUID=5a96a5f0-fa17-40ff-940f-dd731c3671ea; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food consumption and compound intake|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838792_15846410:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ad51aa5c441aa405237ca5588ff9574c
ToxValDB_ECHA_IUCLID NOAEL =90 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaafde4b0a7c65d1b8611; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5067/7/9/2?documentUUID=5a96a5f0-fa17-40ff-940f-dd731c3671ea; YEAR=0; ORIGINAL_YEAR=0; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15861135_15861453_15861644_15862441:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_550c4180bf79e9bef85cfcd8be261e95
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =0.71 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632707:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_51f0ee4d70c5d70cf91f3eeea2cac169
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier IZJ9BVRDO7 UNII - - - chemical {"approval_status":null,"molecular_formula":"C21H24O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"IZJ9BVRDO7"}
openFDA substances FDA UNII substance identifier IZJ9BVRDO7 UNII - - - chemical {"approval_status":null,"molecular_formula":"C21H24O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"IZJ9BVRDO7"}
openFDA substances FDA UNII substance identifier IZJ9BVRDO7 UNII - - - chemical {"approval_status":null,"molecular_formula":"C21H24O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"IZJ9BVRDO7"}
openFDA substances FDA UNII substance identifier IZJ9BVRDO7 UNII - - - chemical {"approval_status":null,"molecular_formula":"C21H24O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"IZJ9BVRDO7"}