NOAEL Studies
Preservative
Bronopol NOAEL Studies
INCI: BRONOPOL
CAS: 52-51-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 32 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=81cda80a-4c7b-4607-a16c-682a3631da5d.i6z; document=64ba93f7-ee96-4fde-8152-432c2b7639e2_81cda80a-4c7b-4607-a16c-682a3631da5d.i6d; document_key=64ba93f7-ee96-4fde-8152-432c2b7639e2/81cda80a-4c7b-4607-a16c-682a3631da5d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1976; basis=other:; key_result=false; entry_uuid=8776867a-f722-43ff-a65d-9896c5259620 |
| ECHA | LOAEL | 30 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=81cda80a-4c7b-4607-a16c-682a3631da5d.i6z; document=0563d001-43ca-4878-8762-dc9da8af6b62_81cda80a-4c7b-4607-a16c-682a3631da5d.i6d; document_key=0563d001-43ca-4878-8762-dc9da8af6b62/81cda80a-4c7b-4607-a16c-682a3631da5d; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-08-29; basis=body weight and weight gain; key_result=false; entry_uuid=5430293e-7b64-47fc-b9e0-b85611fc6dcb |
| ECHA | LOAEL | 80 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=81cda80a-4c7b-4607-a16c-682a3631da5d.i6z; document=cbbd8bd3-f134-445c-86fc-ef57b1180440_81cda80a-4c7b-4607-a16c-682a3631da5d.i6d; document_key=cbbd8bd3-f134-445c-86fc-ef57b1180440/81cda80a-4c7b-4607-a16c-682a3631da5d; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; key_result=false; entry_uuid=a127140e-8053-4072-9b09-b1b7a39eea87 |
| ECHA | LOAEL | 20 | mg/kg bw/day | dog | oral: gavage | - | sub-chronic toxicity: oral | dossier=81cda80a-4c7b-4607-a16c-682a3631da5d.i6z; document=fd464039-b739-4769-aa92-92b653d9cc31_81cda80a-4c7b-4607-a16c-682a3631da5d.i6d; document_key=fd464039-b739-4769-aa92-92b653d9cc31/81cda80a-4c7b-4607-a16c-682a3631da5d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1973; basis=clinical signs; key_result=false; entry_uuid=b239c166-3ba0-4917-9c95-04754d3be0de |
| ECHA | NOAEL | 80 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=81cda80a-4c7b-4607-a16c-682a3631da5d.i6z; document=c307ce9b-01ba-4b69-9c99-5fe403c49e87_81cda80a-4c7b-4607-a16c-682a3631da5d.i6d; document_key=c307ce9b-01ba-4b69-9c99-5fe403c49e87/81cda80a-4c7b-4607-a16c-682a3631da5d; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=false; entry_uuid=64a96da7-be5a-4811-9843-56ba7eaa9c00 |
| ECHA | NOAEL | <=25 | mg/kg bw/day | rat | oral: drinking water | - | two-generation reproductive toxicity | dossier=81cda80a-4c7b-4607-a16c-682a3631da5d.i6z; document=39ff1bab-5675-4dd5-8ca5-8f4b1a1f29b9_81cda80a-4c7b-4607-a16c-682a3631da5d.i6d; document_key=39ff1bab-5675-4dd5-8ca5-8f4b1a1f29b9/81cda80a-4c7b-4607-a16c-682a3631da5d; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1987; basis=other:; key_result=true; upper_value=25; entry_uuid=476efed8-2f67-4cbf-bb92-2644107cd66b |
| ECHA | NOAEL | 200 | mg/kg bw/day | rat | oral: drinking water | - | two-generation reproductive toxicity | dossier=81cda80a-4c7b-4607-a16c-682a3631da5d.i6z; document=39ff1bab-5675-4dd5-8ca5-8f4b1a1f29b9_81cda80a-4c7b-4607-a16c-682a3631da5d.i6d; document_key=39ff1bab-5675-4dd5-8ca5-8f4b1a1f29b9/81cda80a-4c7b-4607-a16c-682a3631da5d; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1987; basis=reproductive performance; key_result=true; entry_uuid=425d9ab3-bcd7-4c3d-b559-6af06129aeb6 |
| ECHA | NOAEL | 7 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=81cda80a-4c7b-4607-a16c-682a3631da5d.i6z; document=64ba93f7-ee96-4fde-8152-432c2b7639e2_81cda80a-4c7b-4607-a16c-682a3631da5d.i6d; document_key=64ba93f7-ee96-4fde-8152-432c2b7639e2/81cda80a-4c7b-4607-a16c-682a3631da5d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1976; basis=other:; key_result=true; entry_uuid=94c8ee1e-f752-4652-a2b6-6aeba8d0ef2b |
| ECHA | NOAEL | 10 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=81cda80a-4c7b-4607-a16c-682a3631da5d.i6z; document=0563d001-43ca-4878-8762-dc9da8af6b62_81cda80a-4c7b-4607-a16c-682a3631da5d.i6d; document_key=0563d001-43ca-4878-8762-dc9da8af6b62/81cda80a-4c7b-4607-a16c-682a3631da5d; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-08-29; basis=other:; key_result=false; entry_uuid=f8c05edd-6139-496a-bbd8-681f8286f7ec |
| ECHA | NOAEL | <=20 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=81cda80a-4c7b-4607-a16c-682a3631da5d.i6z; document=a35a557b-af5c-4a73-822f-b2fca2dd15a4_81cda80a-4c7b-4607-a16c-682a3631da5d.i6d; document_key=a35a557b-af5c-4a73-822f-b2fca2dd15a4/81cda80a-4c7b-4607-a16c-682a3631da5d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1973; basis=gross pathology; key_result=true; upper_value=20; entry_uuid=8b33ca23-7d1b-4750-aa9e-946c53da63df |
| ECHA | NOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=81cda80a-4c7b-4607-a16c-682a3631da5d.i6z; document=5d140647-15f6-4de4-adda-0b3a8fc6bf41_81cda80a-4c7b-4607-a16c-682a3631da5d.i6d; document_key=5d140647-15f6-4de4-adda-0b3a8fc6bf41/81cda80a-4c7b-4607-a16c-682a3631da5d; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1993; key_result=false; entry_uuid=e44f1fc4-99e0-491c-8790-5dc629243fbc |
| ECHA | NOAEL | 40 | mg/kg bw/day | rat | oral: gavage | - | one-generation reproductive toxicity | dossier=81cda80a-4c7b-4607-a16c-682a3631da5d.i6z; document=113d71f3-95f1-4b86-bb03-d9aac592b2e8_81cda80a-4c7b-4607-a16c-682a3631da5d.i6d; document_key=113d71f3-95f1-4b86-bb03-d9aac592b2e8/81cda80a-4c7b-4607-a16c-682a3631da5d; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1973; basis=reproductive performance; key_result=true; entry_uuid=02846427-925f-4166-a711-d01da3be67dc |
| ECHA | NOAEL | 50 | mg/kg bw/day | rat | oral: drinking water | - | two-generation reproductive toxicity | dossier=81cda80a-4c7b-4607-a16c-682a3631da5d.i6z; document=7c6d339c-011a-45b6-a149-0690e81083a5_81cda80a-4c7b-4607-a16c-682a3631da5d.i6d; document_key=7c6d339c-011a-45b6-a149-0690e81083a5/81cda80a-4c7b-4607-a16c-682a3631da5d; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2008; ReportDate=2008-03-13; basis=reproductive performance; key_result=false; entry_uuid=ca6f88d7-e24f-426b-abe7-25311aba2f64 |
| ECHA | NOAEL | 8 | mg/kg bw/day | dog | oral: gavage | - | sub-chronic toxicity: oral | dossier=81cda80a-4c7b-4607-a16c-682a3631da5d.i6z; document=fd464039-b739-4769-aa92-92b653d9cc31_81cda80a-4c7b-4607-a16c-682a3631da5d.i6d; document_key=fd464039-b739-4769-aa92-92b653d9cc31/81cda80a-4c7b-4607-a16c-682a3631da5d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1973; basis=clinical signs; key_result=true; entry_uuid=59ac2e94-6895-4cad-942c-1aea83086902 |
NTP ICE acute dermal 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute dermal | EPA classification | 3 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=2162; Record_ID=acute_dermal_8; Data_Type=In Vivo; Formulation_ID=MIX8; Formulation_Name=Acticide LA 2605-F; Percent_Active_Ingredient=5.3; Mixture=Mixture; DTXSID=DTXSID8024652; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=3.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE acute dermal | EPA classification | 4 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=2166; Record_ID=acute_dermal_368; Data_Type=In Vivo; Formulation_ID=MIX361; Formulation_Name=Preventol P 91; Percent_Active_Ingredient=9.97; Mixture=Mixture; DTXSID=DTXSID8024652; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE acute dermal | GHS classification | 5 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=2168; Record_ID=acute_dermal_8; Data_Type=In Vivo; Formulation_ID=MIX8; Formulation_Name=Acticide LA 2605-F; Percent_Active_Ingredient=5.3; Mixture=Mixture; DTXSID=DTXSID8024652; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE acute dermal | LD50 | >5000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=2163; Record_ID=acute_dermal_406; Data_Type=In Vivo; Formulation_ID=MIX400; Formulation_Name=Rocima 586; Percent_Active_Ingredient=7.5; Mixture=Mixture; DTXSID=DTXSID8024652; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE acute dermal | LD50 | >2000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=2165; Record_ID=acute_dermal_8; Data_Type=In Vivo; Formulation_ID=MIX8; Formulation_Name=Acticide LA 2605-F; Percent_Active_Ingredient=5.3; Mixture=Mixture; DTXSID=DTXSID8024652; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=2000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
NTP ICE acute inhalation 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | EPA Classification | 3 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4568; Record_ID=acute_inhalation_293; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX361; Formulation_Name=Preventol P 91; Percent_Active_Ingredient=9.97; Mixture=Mixture; DTXSID=DTXSID8024652; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE acute inhalation | EPA Classification | 2 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4570; Record_ID=acute_inhalation_29; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX8; Formulation_Name=Acticide LA 2605-F; Percent_Active_Ingredient=5.3; Mixture=Mixture; DTXSID=DTXSID8024652; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=2; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE acute inhalation | GHS Classification | 4 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4575; Record_ID=acute_inhalation_329; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX400; Formulation_Name=Rocima 586; Percent_Active_Ingredient=7.5; Mixture=Mixture; DTXSID=DTXSID8024652; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE acute inhalation | LC50 | 1.69 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4572; Record_ID=acute_inhalation_329; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX400; Formulation_Name=Rocima 586; Percent_Active_Ingredient=7.5; Mixture=Mixture; DTXSID=DTXSID8024652; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.69; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE acute inhalation | LC50 | 0.21 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4574; Record_ID=acute_inhalation_29; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX8; Formulation_Name=Acticide LA 2605-F; Percent_Active_Ingredient=5.3; Mixture=Mixture; DTXSID=DTXSID8024652; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.21; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE acute inhalation | LC50 | >5 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4576; Record_ID=acute_inhalation_2996; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024652; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE acute inhalation | LC50 | range0.52 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4577; Record_ID=acute_inhalation_293; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX361; Formulation_Name=Preventol P 91; Percent_Active_Ingredient=9.97; Mixture=Mixture; DTXSID=DTXSID8024652; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=range; Response=>0.52 and <2.05; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
NTP ICE acute oral 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | EPA classification | =2 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12189; row=13788; data_type=In Vivo; mixture=Mixture; formulation_id=MIX8; formulation_name=Acticide LA 2605-F; chemical_name=Bronopol; preferred_name=Bronopol; percent_active_ingredient=5.3; dtxsid=DTXSID8024652; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8024652; source_file=acute_oral.xlsx |
| NTP ICE acute oral | EPA classification | =3 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12959; row=13792; data_type=In Vivo; mixture=Mixture; formulation_id=MIX400; formulation_name=Rocima 586; chemical_name=Bronopol; preferred_name=Bronopol; percent_active_ingredient=7.5; dtxsid=DTXSID8024652; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8024652; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12860; row=13789; data_type=In Vivo; mixture=Mixture; formulation_id=MIX361; formulation_name=Preventol P 91; chemical_name=Bronopol; preferred_name=Bronopol; percent_active_ingredient=9.97; dtxsid=DTXSID8024652; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8024652; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1030 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12860; row=13786; data_type=In Vivo; mixture=Mixture; formulation_id=MIX361; formulation_name=Preventol P 91; chemical_name=Bronopol; preferred_name=Bronopol; percent_active_ingredient=9.97; dtxsid=DTXSID8024652; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8024652; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12959; row=13787; data_type=In Vivo; mixture=Mixture; formulation_id=MIX400; formulation_name=Rocima 586; chemical_name=Bronopol; preferred_name=Bronopol; percent_active_ingredient=7.5; dtxsid=DTXSID8024652; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8024652; source_file=acute_oral.xlsx |
NTP ICE dart 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE dart | LOEL | 80 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=123115; Record_ID=dart_8049; Data_Type=In Vivo; DTXSID=DTXSID8024652; Assay=DART, In life observation; Endpoint=LOEL; Response=80; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0011135;CUI;Defecation; Reference=ToxRefDB v2 , ID = 6181; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE dart | LOEL | 80 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=123117; Record_ID=dart_8174; Data_Type=In Vivo; DTXSID=DTXSID8024652; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=80; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1282719;CUI;Incomplete ossification; Reference=ToxRefDB v2 , ID = 6181; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE dart | LOEL | 40 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=123118; Record_ID=dart_10214; Data_Type=In Vivo; DTXSID=DTXSID8024652; Assay=DART, In life observation; Endpoint=LOEL; Response=40; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0005910;CUI;Body Weight; Reference=ToxRefDB v2 , ID = 6645; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5760; RecordID=ARPathway2016_1275; DatasetName=ARPathway2016; DTXSID=DTXSID8024652; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
NTP ICE eye irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | EPA Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2447; Record_ID=eye_irritation_968; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID822; Formulation_Name=Rocima 586; Percent_Active_Ingredient=7.5; Mixture=Mixture; DTXSID=DTXSID8024652; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
NTP ICE skin irritation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | EPA classification | 2 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1643; Record_ID=skin_irritation_invivo_378; Data_Type=In Vivo; Formulation_ID=MIX361; Formulation_Name=Preventol P 91; Percent_Active_Ingredient=9.97; Mixture=Mixture; DTXSID=DTXSID8024652; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE skin irritation | EPA classification | 1 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1645; Record_ID=skin_irritation_invivo_892; Data_Type=In Vivo; Formulation_ID=MIX400; Formulation_Name=Rocima 586; Percent_Active_Ingredient=7.5; Mixture=Mixture; DTXSID=DTXSID8024652; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Male/Female; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
NTP ICE skin sensitization 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 2.114 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7758; Record_ID=skin_sensitization_invivo_1755; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8024652; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=2.114; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE skin sensitization | Concentration, one positive response | 0.4545 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7754; Record_ID=skin_sensitization_invivo_1755; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8024652; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.4545; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE skin sensitization | GHS Classification | 1 | unitless | Guinea pig | Dermal | - | In Vivo; SkinSensitization6pack; Guinea Pig Maximization/Buehler | sheet=Data_invivo; excel_row=730; Record_ID=skin_sensitization_invivo_25; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX8; Formulation_Name=Acticide LA 2605-F; Percent_Active_Ingredient=5.3; Mixture=Mixture; DTXSID=DTXSID8024652; Assay=Guinea Pig Maximization/Buehler; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Guinea pig; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7744; Record_ID=skin_sensitization_invivo_1754; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8024652; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE skin sensitization | Incidence of positive responses | 11.83 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7750; Record_ID=skin_sensitization_invivo_1755; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8024652; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=11.83; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE skin sensitization | Induction dose per skin area | 1395 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7742; Record_ID=skin_sensitization_invivo_1754; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8024652; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=1395; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE skin sensitization | Induction dose per skin area | 3488 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7748; Record_ID=skin_sensitization_invivo_1755; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8024652; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=3488; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 1474 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7760; Record_ID=skin_sensitization_invivo_1755; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8024652; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=1474; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | 317 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7756; Record_ID=skin_sensitization_invivo_1755; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8024652; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=317; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE skin sensitization | Relative reliability score | 2 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7747; Record_ID=skin_sensitization_invivo_1754; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8024652; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=7762; Record_ID=skin_sensitization_invivo_1755; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8024652; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024652; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024652 |
EPA ToxRefDB v3 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =80 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 7 GD to 19 GD | DEV | study_id=6181; toxval_study_source_id=studyid6181_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-defecation|in life observation-food consumption-food consumption|in life observation-body weight-body weight gain; dose_level=4; study_year=1991; study_citation=Irvine, L.F.H. 1991. Bronopol: Oral (Gavage) Rabbit Developmental Toxicity (Teratogenicity) study: Study No. BON/3/91. Prepared by Toxicol Laboratories Limited, Bromyard Road, Ledbury, Herefordshire, HR8 1LH, England.; dsstox_substance_id=DTXSID8024652; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =10 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley) | oral | 0 week to 104 week | CHR | study_id=6183; toxval_study_source_id=studyid6183_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|organ weight-liver-relative to body weight|urinalysis-volume-volume|in life observation-body weight-body weight gain|pathology gross-stomach-ulcer|in life observation-food consumption-food efficiency|organ weight-thyroid gland-absolute|pathology gross-stomach-thickened|pathology microscopic-salivary glands-dilatation|pathology microscopic-stomach-ulcer|pathology microscopic-kidney-glomerulonephropathy|urinalysis-occult blood-blood|pathology microscopic-stomach-hyperplasia|pathology gross-stomach-irregular surface|in life observation-clinical signs-fur (altered appearance)|pathology microscopic-salivary glands-metaplasia|pathology microscopic-lymph node-dilatation|pathology microscopic-salivary glands-atrophy|in life observation-mortality-mortality|in life observation-food consumption-food consumption|in life observation-body weight-body weight|pathology microscopic-stomach-squamous cell papilloma|organ weight-heart-absolute|pathology microscopic-salivary glands-inflammation|organ weight-kidney-relative to body weight|organ weight-kidney-absolute|organ weight-brain-relative to body weight|organ weight-adrenal gland-relative to body weight|organ weight-lung-relative to body weight|in life observation-clinical signs-frequent face washing; dose_level=1; study_year=1976; dsstox_substance_id=DTXSID8024652; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =4.27 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 28 day | SAC | study_id=6646; toxval_study_source_id=studyid6646_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-nose-inflammation|pathology microscopic-stomach-hypertrophy; dose_level=1; study_year=2006; study_citation=C Stewart. 2006. Bronopol: 28-Day Drinking Water Toxicity Study in Beagle Dogs. The Dow Chemical Company. MRID 47081001. Unpublished.; dsstox_substance_id=DTXSID8024652; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =4.1 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 28 day | SAC | study_id=6646; toxval_study_source_id=studyid6646_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-nose-inflammation|pathology microscopic-stomach-hypertrophy; dose_level=1; study_year=2006; study_citation=C Stewart. 2006. Bronopol: 28-Day Drinking Water Toxicity Study in Beagle Dogs. The Dow Chemical Company. MRID 47081001. Unpublished.; dsstox_substance_id=DTXSID8024652; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =150 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=6661; toxval_study_source_id=studyid6661_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-dystocia-dystocia; dose_level=3; study_year=2008; study_citation=EW Carney et al. 2008. Bronopol: Two Generation Drinking Water Reproductive Toxicity Study in Crl:CD(SD) Rats. The Dow Chemical Company. MRID 47455601. Unpublished.; dsstox_substance_id=DTXSID8024652; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =40 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley) | oral | 0 week to 104 week | CHR | study_id=6183; toxval_study_source_id=studyid6183_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption; dose_level=2; study_year=1976; dsstox_substance_id=DTXSID8024652; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =40 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 7 GD to 19 GD | DEV | study_id=6181; toxval_study_source_id=studyid6181_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-defecation|in life observation-food consumption-food consumption|in life observation-body weight-body weight gain; dose_level=3; study_year=1991; study_citation=Irvine, L.F.H. 1991. Bronopol: Oral (Gavage) Rabbit Developmental Toxicity (Teratogenicity) study: Study No. BON/3/91. Prepared by Toxicol Laboratories Limited, Bromyard Road, Ledbury, Herefordshire, HR8 1LH, England.; dsstox_substance_id=DTXSID8024652; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =28 | mg/kg bw/day | rat (sprague dawley; sprague dawley) | oral | 6 GD to 15 GD | DEV | study_id=6182; toxval_study_source_id=studyid6182_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=2; study_year=1995; study_citation=Palmer, K. (1995) Bronopol: Oral (Gavage) Rat Developmental Toxicity study. Study No. BON/9/95. Unpublished.; dsstox_substance_id=DTXSID8024652; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley) | oral | 0 week to 104 week | CHR | study_id=6183; toxval_study_source_id=studyid6183_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-squamous cell papilloma|in life observation-clinical signs-frequent face washing|organ weight-lung-relative to body weight|pathology microscopic-stomach-hyperplasia|in life observation-mortality-mortality|pathology microscopic-salivary glands-atrophy|pathology microscopic-lymph node-dilatation|organ weight-heart-absolute|pathology microscopic-salivary glands-inflammation|in life observation-food consumption-food consumption|in life observation-body weight-body weight|pathology microscopic-stomach-ulcer|organ weight-kidney-absolute|pathology microscopic-kidney-glomerulonephropathy|organ weight-kidney-relative to body weight|organ weight-adrenal gland-relative to body weight|organ weight-brain-relative to body weight|pathology microscopic-salivary glands-dilatation|urinalysis-volume-volume|pathology microscopic-salivary glands-metaplasia|in life observation-clinical signs-fur (altered appearance)|pathology gross-stomach-irregular surface|in life observation-water consumption-water consumption|organ weight-liver-relative to body weight|pathology gross-stomach-ulcer|in life observation-food consumption-food efficiency|in life observation-body weight-body weight gain|organ weight-thyroid gland-absolute|pathology gross-stomach-thickened|urinalysis-occult blood-blood; dose_level=0; study_year=1976; dsstox_substance_id=DTXSID8024652; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =50 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=6661; toxval_study_source_id=studyid6661_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-dystocia-dystocia; dose_level=2; study_year=2008; study_citation=EW Carney et al. 2008. Bronopol: Two Generation Drinking Water Reproductive Toxicity Study in Crl:CD(SD) Rats. The Dow Chemical Company. MRID 47455601. Unpublished.; dsstox_substance_id=DTXSID8024652; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =10 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=6661; toxval_study_source_id=studyid6661_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-erosion|pathology microscopic-liver-vacuolization|organ weight-thyroid gland-absolute|organ weight-kidney-relative to body weight|pathology microscopic-stomach-inflammation|in life observation-body weight-body weight gain|in life observation-food consumption-food consumption|organ weight-kidney-absolute|pathology microscopic-stomach-ulcer|organ weight-thyroid gland-relative to body weight|pathology microscopic-thyroid gland-dilatation|pathology microscopic-kidney-inflammation|in life observation-water consumption-water consumption|pathology microscopic-kidney-dilatation|pathology microscopic-kidney-degeneration; dose_level=1; study_year=2008; study_citation=EW Carney et al. 2008. Bronopol: Two Generation Drinking Water Reproductive Toxicity Study in Crl:CD(SD) Rats. The Dow Chemical Company. MRID 47455601. Unpublished.; dsstox_substance_id=DTXSID8024652; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =2.5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630330_15630331:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a3384d9f22eea33eaef7238dea5acda9 |
| ToxValDB GESTIS DNEL | DNEL systemic | =3.5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630330_15630331:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_724a399a54a42f894bfc19c1b3b518d1 |
ToxValDB HESS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | LOEL | =90 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0ddae4b0a676289dde66; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Deaths|Clinical Observation: Locomotor activity decrease, Abnormal respiratory sound Deep respiration Pale skin Hypothermia Ptosis Salivation Rough fur|Functional Observational Battery: Righting reflex decrease, Hind limb grip strength decrease|Body Weight Changes: decrease|Urinalysis: Occult blood|Necropsy: Lung-Reddish area Glandular stomach-Reddish, mucosa|Histopathology: Forestomach-Squamous hyperplasia Glandular stomach-Hyperplasia, surface epithelium Glandular stomach-Necrosis Duodenum-Erosion Kidney-Hyperplasia,collecting tubular epithelium Kidney-Dilatation, tubular R Kidney-Basophlic tubule Urinary bladder-Hyperplasia, transitional cell, simple Thymus-Atrophy Testis-Hypospermatogenesis Testis-Hyperplasia, interstitial cell, diffuse Epididymis-Decrease, sperm Epididymis-Atrophy Liver-Necrosis, focal Liver-Congestion Trachea-Inflammation Lung-Inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|gross pathology|mortality/survival|neurobehavior|nonneoplastic histopathology|urinalysis; STUDY_GROUP=HESS_dup_-_15638878_15638879:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f178562583a27eb3a40eb8142ee23231 |
| ToxValDB HESS | NOEL | =30 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0ddae4b0a676289dde66; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Necropsy: Lung-Reddish area|Histopathology: Lung-Inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|nonneoplastic histopathology; STUDY_GROUP=HESS_dup_-_15638878_15638879:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c1c7f5d8f73c85090637ff1ac5b5065b |
| ToxValDB HESS | NOEL | =10 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0ddae4b0a676289dde66; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Clinical Observation: Locomotor activity decrease, Abnormal respiratory sound, Deep respiration, Hypothermia; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=HESS_dup_-_15638984_15638985:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c2ab08131d9fdf8757048abdd10ea5ab |
ToxValDB ToxRefDB 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =80 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Irvine, L.F.H. 1991. Bronopol: Oral (Gavage) Rabbit Developmental Toxicity (Teratogenicity) study: Study No. BON/3/91. Prepared by Toxicol Laboratories Limited, Bromyard Road, Ledbury, Herefordshire, HR8 1LH, England.; TITLE=Bronopol: Oral (Gavage) Rabbit Developmental Toxicity (Teratogenicity) study; AUTHOR=Irvine, L.F.H; EXTERNAL_SOURCE_ID=6181; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-defecation|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15711178_15711179_15711180_15711181:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_96ac37723661fe93fd6910d8e6f434fe |
| ToxValDB ToxRefDB | LEL | =10 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | EXTERNAL_SOURCE_ID=6183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-lymph node-dilatation|systemic: pathology microscopic-salivary glands-dilatation|systemic: pathology microscopic-salivary glands-atrophy|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-stomach-ulcer|systemic: urinalysis-volume-volume|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-kidney-glomerulonephropathy|systemic: organ weight-lung-relative to body weight|systemic: pathology microscopic-stomach-squamous cell papilloma|systemic: in life observation-body weight-body weight gain|systemic: pathology gross-stomach-ulcer|systemic: in life observation-food consumption-food efficiency|systemic: organ weight-heart-absolute|systemic: pathology microscopic-salivary glands-inflammation|systemic: in life observation-clinical signs-frequent face washing|systemic: organ weight-thyroid gland-absolute|systemic: organ weight-kidney-relative to body weight|systemic: urinalysis-occult blood-blood|systemic: organ weight-kidney-absolute|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology gross-stomach-irregular surface|systemic: organ weight-brain-relative to body weight|systemic: organ weight-adrenal gland-relative to body weight|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: pathology gross-stomach-thickened|systemic: pathology microscopic-salivary glands-metaplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical signs|food and/or water consumption|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15711194_15711195_15711196:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_38b576ec1c523683fbb3e95486eb1205 |
| ToxValDB ToxRefDB | LEL | =4.27 | mg/kg bw/day | Dog | oral | short-term; 28 days | short-term | LONG_REF=C Stewart. 2006. Bronopol: 28-Day Drinking Water Toxicity Study in Beagle Dogs. The Dow Chemical Company. MRID 47081001. Unpublished.; TITLE=Bronopol: 28-Day Drinking Water Toxicity Study in Beagle Dogs; AUTHOR=C Stewart; EXTERNAL_SOURCE_ID=6646; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-nose-inflammation|systemic: pathology microscopic-stomach-hypertrophy; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB:15712381:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ccb091d622ddc491c116a83ec04b38be |
| ToxValDB ToxRefDB | LEL | =4.1 | mg/kg bw/day | Dog | oral | short-term; 28 days | short-term | LONG_REF=C Stewart. 2006. Bronopol: 28-Day Drinking Water Toxicity Study in Beagle Dogs. The Dow Chemical Company. MRID 47081001. Unpublished.; TITLE=Bronopol: 28-Day Drinking Water Toxicity Study in Beagle Dogs; AUTHOR=C Stewart; EXTERNAL_SOURCE_ID=6646; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-nose-inflammation|systemic: pathology microscopic-stomach-hypertrophy; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB:15712382:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c7aaf85a053d3ac038bfdc3716a40e9a |
| ToxValDB ToxRefDB | LEL | =150 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=EW Carney et al. 2008. Bronopol: Two Generation Drinking Water Reproductive Toxicity Study in Crl:CD(SD) Rats. The Dow Chemical Company. MRID 47455601. Unpublished.; TITLE=Bronopol: Two Generation Drinking Water Reproductive Toxicity Study in Crl:CD(SD) Rats; AUTHOR=EW Carney et al; EXTERNAL_SOURCE_ID=6661; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-dystocia-dystocia; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15712391_15712392_15712393_15712394:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_afbeca46974ffaec1849b5a29a2aaca1 |
| ToxValDB ToxRefDB | LOAEL | =40 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | EXTERNAL_SOURCE_ID=6183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15711194_15711195_15711196:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6f036b03c4456a744637884fb902bcd9 |
| ToxValDB ToxRefDB | NEL | =40 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Irvine, L.F.H. 1991. Bronopol: Oral (Gavage) Rabbit Developmental Toxicity (Teratogenicity) study: Study No. BON/3/91. Prepared by Toxicol Laboratories Limited, Bromyard Road, Ledbury, Herefordshire, HR8 1LH, England.; TITLE=Bronopol: Oral (Gavage) Rabbit Developmental Toxicity (Teratogenicity) study; AUTHOR=Irvine, L.F.H; EXTERNAL_SOURCE_ID=6181; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-defecation|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15711178_15711179_15711180_15711181:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4ca19431d4bc706c365276f6ef636c0c |
| ToxValDB ToxRefDB | NEL | =28 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Palmer, K. (1995) Bronopol: Oral (Gavage) Rat Developmental Toxicity study. Study No. BON/9/95. Unpublished.; TITLE=Bronopol: Oral (Gavage) Rat Developmental Toxicity study; AUTHOR=Palmer, K; EXTERNAL_SOURCE_ID=6182; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15711186_15711187_15711188_15711189:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_21a2dee30a1cde703da736e104966a9e |
| ToxValDB ToxRefDB | NEL | =50 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=EW Carney et al. 2008. Bronopol: Two Generation Drinking Water Reproductive Toxicity Study in Crl:CD(SD) Rats. The Dow Chemical Company. MRID 47455601. Unpublished.; TITLE=Bronopol: Two Generation Drinking Water Reproductive Toxicity Study in Crl:CD(SD) Rats; AUTHOR=EW Carney et al; EXTERNAL_SOURCE_ID=6661; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-dystocia-dystocia; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15712391_15712392_15712393_15712394:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_79d674dc3b94d31b9f2fb3bf68db59f2 |
| ToxValDB ToxRefDB | NEL | =10 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=EW Carney et al. 2008. Bronopol: Two Generation Drinking Water Reproductive Toxicity Study in Crl:CD(SD) Rats. The Dow Chemical Company. MRID 47455601. Unpublished.; TITLE=Bronopol: Two Generation Drinking Water Reproductive Toxicity Study in Crl:CD(SD) Rats; AUTHOR=EW Carney et al; EXTERNAL_SOURCE_ID=6661; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-inflammation|systemic: in life observation-body weight-body weight gain|systemic: organ weight-kidney-relative to body weight|systemic: pathology microscopic-stomach-erosion|systemic: in life observation-water consumption-water consumption|systemic: in life observation-food consumption-food consumption|systemic: organ weight-kidney-absolute|systemic: pathology microscopic-liver-vacuolization|systemic: pathology microscopic-stomach-ulcer|systemic: organ weight-thyroid gland-relative to body weight|systemic: pathology microscopic-thyroid gland-dilatation|systemic: pathology microscopic-kidney-dilatation|systemic: organ weight-thyroid gland-absolute|systemic: pathology microscopic-kidney-degeneration|systemic: pathology microscopic-kidney-inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15712399_15712400_15712401_15712402:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3a8ea8d75a0340ebcdfdaf218e41d21a |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 6PU1E16C9W | UNII | - | - | - | chemical | - |