Bruceine

INCI: BRUCEINE

CAS Number
25514-31-2
Function
Antimicrobial, skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific FDA cosmetic restriction; primarily a research/pharmaceutical compound with very limited cosmetic use.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Bruceine is a quassinoid compound derived from Brucea javanica with anti-inflammatory, anti-malarial, and antiviral activity, primarily used in pharmaceutical and research contexts. Safety at cosmetic use concentrations is not fully established, and it has very limited documented cosmetic use. Caution is advised.

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Concern Level: Moderate

Regulatory Flags

pharmaceutical_compound data_gap cytotoxic_high_dose verify_inci_name

Frequently Asked Questions

Is Bruceine safe in cosmetics?

Bruceine is a quassinoid compound derived from Brucea javanica with anti-inflammatory, anti-malarial, and antiviral activity, primarily used in pharmaceutical and research contexts. Safety at cosmetic use concentrations is not fully established, and it has very limited documented cosmetic use. Caution is advised. The EU classifies Bruceine as "permitted". Safety rating: MODERATE.

Is Bruceine allowed in the EU?

Bruceine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Bruceine do in cosmetics?

Bruceine functions as: Antimicrobial, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 25514-31-2.

What is the Margin of Safety for Bruceine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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