NOAEL Studies
Cosmetic Ingredient
Butoxydiglycol NOAEL Studies
INCI: BUTOXYDIGLYCOL
CAS: 112-34-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP ICE acute oral 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =4500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1177; row=13315; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Butoxyethoxy)ethanol; preferred_name=2-(2-Butoxyethoxy)ethanol; dtxsid=DTXSID8021519; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021519; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021519; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >5000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1178; row=13321; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Butoxyethoxy)ethanol; preferred_name=2-(2-Butoxyethoxy)ethanol; dtxsid=DTXSID8021519; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021519; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021519; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =5080 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_1179; row=13314; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Butoxyethoxy)ethanol; preferred_name=2-(2-Butoxyethoxy)ethanol; dtxsid=DTXSID8021519; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021519; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021519; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =5660 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1180; row=13313; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Butoxyethoxy)ethanol; preferred_name=2-(2-Butoxyethoxy)ethanol; dtxsid=DTXSID8021519; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021519; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021519; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =6050 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_1181; row=13312; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Butoxyethoxy)ethanol; preferred_name=2-(2-Butoxyethoxy)ethanol; dtxsid=DTXSID8021519; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021519; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021519; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =6530 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_1182; row=13310; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Butoxyethoxy)ethanol; preferred_name=2-(2-Butoxyethoxy)ethanol; dtxsid=DTXSID8021519; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021519; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021519; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =6560 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_1183; row=13320; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Butoxyethoxy)ethanol; preferred_name=2-(2-Butoxyethoxy)ethanol; dtxsid=DTXSID8021519; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021519; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021519; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =6600 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1184; row=13319; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Butoxyethoxy)ethanol; preferred_name=2-(2-Butoxyethoxy)ethanol; dtxsid=DTXSID8021519; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021519; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021519; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =7291 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_1185; row=13318; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Butoxyethoxy)ethanol; preferred_name=2-(2-Butoxyethoxy)ethanol; dtxsid=DTXSID8021519; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021519; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021519; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =7292 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1186; row=13317; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Butoxyethoxy)ethanol; preferred_name=2-(2-Butoxyethoxy)ethanol; dtxsid=DTXSID8021519; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021519; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021519; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =7300 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_1187; row=13316; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Butoxyethoxy)ethanol; preferred_name=2-(2-Butoxyethoxy)ethanol; dtxsid=DTXSID8021519; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021519; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021519; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =9623 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_1188; row=13311; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Butoxyethoxy)ethanol; preferred_name=2-(2-Butoxyethoxy)ethanol; dtxsid=DTXSID8021519; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021519; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021519; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=1402; RecordID=ARPathway2016_604; DatasetName=ARPathway2016; DTXSID=DTXSID8021519; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021519; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021519 |
SCCS Opinion 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =2.6 | mg/kg | rat | oral | 13 week | dermal absorption | p.18 |
| SCCS Opinion | NOAEL | =50 | % | rat | oral | 13 week | dermal absorption | p.18 |
| SCCS Opinion | NOAEL | =51 | mg/kg bw/day | rat | oral | 28 days | repeated dose toxicity | p.9 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/day | rat | dermal | 5 days | NOAEL study | p.12 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/d | rat | oral | 5 days | genotoxicity | p.13 |
| SCCS Opinion | NOAEL | =250 | mg/kg | rat | oral | 13 week | dermal absorption | p.18 |
| SCCS Opinion | NOAEL | =500 | mg/kg bw/d | rat | oral | developmental | reproductive toxicity | p.16 |
| SCCS Opinion | NOAEL | =580 | mg/kg bw/day | rat | dermal | 5 days | NOAEL study | p.12 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | rat | oral | 60 days | reproductive toxicity | p.15 |
| SCCS Opinion | NOAEL | =2000 | mg/kg | - | - | - | NOAEL study | p.4 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =56398.9 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15513007:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d5e1276a7e681a6d57eaa1691c09a25f |
ECHA 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEC | =250 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b61f6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14826/7/9/2?documentUUID=71ba2e45-fbd7-417d-9132-f7c68b1eee7d; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=P0: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID:15861286:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_40d99c057a1b4026b30caf0581cec3f5 |
| ECHA | NOAEC | =500 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b61f8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14826/7/9/2?documentUUID=71ba2e45-fbd7-417d-9132-f7c68b1eee7d; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15861195:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_847dd628418ed8c693d0f74bf12afd42 |
| ECHA | NOAEL | =500 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbee2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14826/7/9/3?documentUUID=71ba2e45-fbd7-417d-9132-f7c68b1eee7d; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=maternal: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822423_15823034:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3555bc870c8ae578952cbd4c26fabd28 |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | NOEL | =2050 | mg/kg bw/day | Mouse | oral | short-term (developmental); 8 days | reproduction developmental | LONG_REF=Teratog. Carcinog. Mutagen.7:29-48 Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test 1987; TITLE=Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test; AUTHOR=Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=49969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Mortality: Survival|Growth: Weight|Reproduction: Progeny counts/numbers|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|reproduction; STUDY_GROUP=ECOTOX:15611583:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=a41e6056d6db3139d9474e5a412c12d1 |
ToxValDB EU SCOEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EU SCOEL | NOEL | =94 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | LONG_REF=BASF (1992) Study on the inhalation toxicity of butylglycol as a vapor in rats, 90-day test, Report of Project No. 50I0030/87002; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985c4e4b02565fc7d38d9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/081_2_2-butoxyethoxy_ethanol_oel_en.pdf; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=local irritation of the lung; STUDY_GROUP=EU SCOEL:15952257:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f9d2297a6b371e7f14046514d70fe54 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =67.5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630380:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_36c0aea3e44cd00faba938c6c1060832 |
ToxValDB HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOAEL | =250 | mg/kg bw/day | Rat | oral | chronic; 91 days | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0defe4b0a676289de8e7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Body Weight Changes: Terminal body weight decrease|Food Consumption: decrease|Water Consumption: decrease|Hematology: RBC decrease, HGB decrease, HCT decrease|Blood Chemistry: TP decrease, T-Cho decrease|Absolute Organ Weight: Kidney increase|Relative Organ Weight: Liver increase, Kidney increase; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|hematology|organ weight; STUDY_GROUP=HESS:15638178:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_10bc53042643f459759a7097b911797f |
ToxValDB PPRTV (CPHEA) 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | BMCL (10 HEC) | =0.32 | mg/m3 | Rat | inhalation | subchronic; 5 weeks | subchronic | LONG_REF=Gushow et al. 1984; AUTHOR=Gushow et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1695; TOXICOLOGICAL_EFFECT=hepatocellular vacuolization; STUDY_GROUP=PPRTV (CPHEA):15653537:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ba6dd5e20e4ba1ee71406de655dc6bab |
| ToxValDB PPRTV (CPHEA) | BMDL | =81 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Johnson et al. 2005; AUTHOR=Johnson et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1695; TOXICOLOGICAL_EFFECT=rbc changes; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=PPRTV (CPHEA):15654021:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9f0f490a7b5f586872ffc0162cdb224b |
| ToxValDB PPRTV (CPHEA) | RfC (provisional) | =0.0001 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Gushow et al. 1984; AUTHOR=Gushow et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1695; TOXICOLOGICAL_EFFECT=Hepatocellular vacuolization in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653535_15653536:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dcea5355b4945efbfb396c1c7835f98f |
| ToxValDB PPRTV (CPHEA) | RfC (provisional) | =0.001 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Gushow et al. 1984; AUTHOR=Gushow et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1695; TOXICOLOGICAL_EFFECT=Hepatocellular vacuolization in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653535_15653536:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_63bbeeea71fc2ed4b394719f68c23746 |
| ToxValDB PPRTV (CPHEA) | RfD (provisional) | =0.03 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Johnson et al. 2005; AUTHOR=Johnson et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1695; TOXICOLOGICAL_EFFECT=RBC changes in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653533_15653691:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6a201085eda51fcf4399f9f850b1767f |
| ToxValDB PPRTV (CPHEA) | RfD (provisional) | =0.3 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Johnson et al. 2005; AUTHOR=Johnson et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1695; TOXICOLOGICAL_EFFECT=RBC changes in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653533_15653691:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_67f763d08a06ad4a0483d2102b2c1ebb |
Regulatory source 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 250 | mg/kg bw/day | rat | dermal | 5 days | - | p.12 |
| Regulatory source | - | 250 | mg/kg bw/d | rat | oral | 13-week | - | p.18 |
| Regulatory source | - | 580 | mg/kg bw/day | rat | dermal | 5 days | - | p.12 |
| Regulatory source | - | 2000 | mg/kg | - | - | - | - | p.4 |
| Regulatory source | dermal absorption | =2.6 | mg/kg | rat | oral | 13 week | dermal absorption | p.18 |
| Regulatory source | dermal absorption | 50 | % | rat | oral | 13 week | dermal absorption | p.18 |
| Regulatory source | dermal absorption | =250 | mg/kg | rat | oral | 13 week | dermal absorption | p.18 |
| Regulatory source | genotoxicity | 250 | mg/kg bw/d | rat | oral | 5 days | genotoxicity | p.13 |
| Regulatory source | repeated dose toxicity | 51 | mg/kg bw/day | rat | oral | 28 days | repeated dose toxicity | p.9 |
| Regulatory source | reproductive toxicity | 500 | mg/kg bw/d | rat | oral | developmental | reproductive toxicity | p.16 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/day | rat | oral | 60 days | reproductive toxicity | p.15 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/d | rat | oral | developmental | reproductive toxicity | p.16 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 9TB90IYC0E | UNII | - | - | - | chemical | - |