NOAEL Studies Cosmetic Ingredient

Butoxyethanol NOAEL Studies

INCI: BUTOXYETHANOL

CAS: 111-76-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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Regulatory source 72 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source LOAEL =32 mg/kg/day Rat (F344; M) oral short-term; 2 days short-term ATSDR MRLs; row_hash=f0534935b37f75dc; source_hash=ToxValhc_bd1459974a919cc8e307fdce32268645; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=32; raw_unit=mg/kg/day; method=gavage; effect=hematological; effect_category=hematology; file=toxval_ATSDR_MRLs.xlsx; long_ref=Ghanayem BI, Blair PC, Thompson MB, et al. 1987a. Effect of age on the toxicity and metabolism of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Toxicol Appl Pharmacol91(2):222-234.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bf1
Regulatory source LOAEL =69 mg/kg/day Rat (F344/N; M/F) oral subchronic; 13 weeks subchronic ATSDR MRLs; row_hash=8f23aeb70d9b5320; source_hash=ToxValhc_eac2eb0b36287edac2a2a131e61b0b18; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=69; raw_unit=mg/kg/day; method=drinking water; effect=hepatic; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=NTP. 1993. Ethylene glycol ethers, 2-ethoxyethanoI, 2-butoxyethanol administered in drinking water to F344/N rats and B6C3Fl mice. NTP toxicity report series no. 26. National Toxicology Program, National Institutes of Health, Public Health Services, U.S. Department of Health and Human Services. NIH publication 93-3349.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bf1
Regulatory source NOAEL =2.90004 mg/m3 Human (M) inhalation chronic; 6 years occupational ATSDR MRLs; row_hash=0f89730048748bd2; source_hash=ToxValhc_5f2f0308b3b7d9259306ccfc6f36849f; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=0.6; raw_unit=ppm; effect=hematological; effect_category=hematology; file=toxval_ATSDR_MRLs.xlsx; long_ref=Haufroid V, Thirion F, Mertens P, et al. 1997. Biological monitoring of workers exposed to low levels of 2- butoxyethanol. Int Arch Occup Environ Health 70:232-236.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bf1
Regulatory source NOAEL =120.835 mg/m3 Rat (Fischer 344; M/F) inhalation subchronic; 90 days subchronic ATSDR MRLs; row_hash=bce2112d7f01f597; source_hash=ToxValhc_5176e7c5c0e3796b8000f4eb43eb8e05; raw_endpoint_type=NOAEL (HEC); raw_endpoint_subtype=; raw_value=25; raw_unit=ppm; effect=hematological; effect_category=hematology; file=toxval_ATSDR_MRLs.xlsx; long_ref=Dodd DE, Snellings WM, Maronpot RR, et al. 1983. Ethylene glycol monobutyl ether: Acute, 9-day, and 90-day vapor inhalation studies in Fischer 344 rats. Toxicol Appl Pharmacol68(3):405-414.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bf1
Regulatory source NOAEL =241.67 mg/m3 Rat (Fischer 344; F) inhalation short-term (developmental); 10 days reproduction developmental ATSDR MRLs; row_hash=a85b08822ff1270b; source_hash=ToxValhc_8af693f227f72aff2a70b90332453526; raw_endpoint_type=NOAEL (HEC); raw_endpoint_subtype=; raw_value=50; raw_unit=ppm; effect=hematological; effect_category=hematology; file=toxval_ATSDR_MRLs.xlsx; long_ref=Tyl RW, Millicovsky G, Dodd DE, et al. 1984. Teratologic evaluation of ethylene glycol monobutyl ether in Fischer 344 rats and New Zealand white rabbits following inhalation exposure. Environ Health Perspect 57:47-68.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bf1
Regulatory source BMCL (HEC) =16 mg/m^3 - inhalation chronic IRIS chronic inhalation RfC system PoD row_hash=583ee71a48100827; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=BMCL (HEC): 16 mg/m^3; system=Hematologic; basis=Hemosiderin deposition in the liver; point_of_departure=BMCL (HEC): 16 mg/m^3; composite_uf=10; confidence=Medium/High; dtxsid=DTXSID1024097; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=500; rfc_last_updated=03/31/2010; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0500_summary.pdf
Regulatory source RfC =1.6 mg/m^3 - inhalation chronic IRIS chronic inhalation RfC system row_hash=17af1fe99d0400fc; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=1.6; system=Hematologic; basis=Hemosiderin deposition in the liver; point_of_departure=BMCL (HEC): 16 mg/m^3; composite_uf=10; confidence=Medium/High; dtxsid=DTXSID1024097; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=500; rfc_last_updated=03/31/2010; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0500_summary.pdf
Regulatory source BMDL (HED) =1.4 mg/kg/day - oral chronic IRIS chronic oral RfD system PoD row_hash=1f6a0e4533d656d6; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=BMDL (HED): 1.4 mg/kg-day; system=Hematologic; basis=Hemosiderin deposition in the liver; point_of_departure=BMDL (HED): 1.4 mg/kg-day; composite_uf=10; confidence=Medium/High; dtxsid=DTXSID1024097; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=500; rfd_last_updated=03/31/2010; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0500_summary.pdf
Regulatory source RfD =0.1 mg/kg/day - oral chronic IRIS chronic oral RfD system row_hash=2fdd615ae8d644e1; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=1e-1; system=Hematologic; basis=Hemosiderin deposition in the liver; point_of_departure=BMDL (HED): 1.4 mg/kg-day; composite_uf=10; confidence=Medium/High; dtxsid=DTXSID1024097; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=500; rfd_last_updated=03/31/2010; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0500_summary.pdf
Regulatory source - =0.05 % - - 90 days - p.23
Regulatory source - 0.25 % - oral - - p.21
Regulatory source - 0.5 % rat - 90 days - p.21
Regulatory source - 23 - - - - - p.23
Regulatory source - 23 - - - 90 days - p.23
Regulatory source - 24 - - - - - p.24
Regulatory source - 27 - - - - - p.27
Regulatory source - 30 mg/kg bw/day - - - - p.48
Regulatory source - =76 - - - 90 days - p.23
Regulatory source - 82 mg/kg bw/day rat oral 13 weeks - p.23
Regulatory source - 99 % rat oral - - p.21
Regulatory source - 129 mg/kg bw/d rat - - - p.23
Regulatory source - 150 mg/kg - - - - p.5
Regulatory source - 150 mg/kg bw/d rat oral 13 weeks - p.23
Regulatory source - 150 mg/kg bw - - - - p.26
Regulatory source - 150 mg/kg bw/d mouse inhalation 9 days - p.55
Regulatory source - 150 mg/kg bw/d - - 13 weeks - p.27
Regulatory source - 222 mg/kg rat oral 90 days - p.21
Regulatory source - 310 mg/kg bw/d rat - 6 days - p.21
Regulatory source - 370 mg/kg bw/d - oral 13 weeks - p.24
Regulatory source - 450 mg/kg rabbit - 14-day - p.26
Regulatory source - 450 mg/kg bw/d rat inhalation 9 days - p.55
Regulatory source - 900 mg/kg bw/d - - 9 days - p.27
Regulatory source - 1000 mg/kg rat inhalation 9 days - p.55
Regulatory source - 1500 mg/kg bw/day - - 4 days - p.27
Regulatory source dermal absorption =1.11 mg/kg bw rat dermal - dermal absorption p.54
Regulatory source dermal absorption =30 mg/kg bw rat dermal - dermal absorption p.54
Regulatory source dermal absorption >50 ppm rat dermal - dermal absorption p.56
Regulatory source dermal absorption 95 µg/cm rat dermal - dermal absorption p.54
Regulatory source developmental toxicity 1 - rat - developmental developmental toxicity p.53
Regulatory source developmental toxicity 30 mg/kg bw/day rat inhalation developmental developmental toxicity p.49
Regulatory source developmental toxicity 30 mg/kg bw/day rat inhalation 3 days developmental toxicity p.56
Regulatory source developmental toxicity 50 ppm rat inhalation 3 days developmental toxicity p.56
Regulatory source developmental toxicity 97 % rat - developmental developmental toxicity p.49
Regulatory source developmental toxicity 100 mg/kg mouse oral developmental developmental toxicity p.48
Regulatory source developmental toxicity 100 mg/kg bw/day rat - developmental developmental toxicity p.49
Regulatory source developmental toxicity 100 mg/kg bw/day rat inhalation developmental developmental toxicity p.49
Regulatory source developmental toxicity 300 mg/kg bw/day mouse oral developmental developmental toxicity p.48
Regulatory source developmental toxicity 350 mg/kg bw/day mouse oral developmental developmental toxicity p.48
Regulatory source developmental toxicity 650 mg/kg bw/day mouse oral developmental developmental toxicity p.48
Regulatory source developmental toxicity 1000 mg/kg mouse oral developmental developmental toxicity p.48
Regulatory source irritation >50 ppm guinea pig dermal - irritation p.14
Regulatory source irritation 129 mg/kg bw/d rat oral 13 weeks irritation p.24
Regulatory source irritation 150 mg/kg bw/d rat oral - irritation p.55
Regulatory source irritation =222 - - oral 6 weeks irritation p.23
Regulatory source irritation 370 mg/kg bw/d rat oral 13 weeks irritation p.24
Regulatory source irritation 1000 mg/kg bw rabbit dermal 9 days irritation p.25
Regulatory source repeated dose toxicity =0.05 % rat oral subchronic repeated dose toxicity p.23
Regulatory source repeated dose toxicity 129 mg/kg bw/d rat oral - repeated dose toxicity p.24
Regulatory source repeated dose toxicity 129 mg/kg bw/d rat oral subchronic repeated dose toxicity p.55
Regulatory source repeated dose toxicity 150 mg/kg bw/d rat oral 4 days repeated dose toxicity p.24
Regulatory source repeated dose toxicity 150 mg/kg bw/d mouse dermal subchronic repeated dose toxicity p.27
Regulatory source repeated dose toxicity 150 mg/kg bw/d rat inhalation 9 days repeated dose toxicity p.27
Regulatory source repeated dose toxicity 370 mg/kg bw rat oral subchronic repeated dose toxicity p.23
Regulatory source repeated dose toxicity 450 mg/kg bw/d rat inhalation 4 days repeated dose toxicity p.27
Regulatory source repeated dose toxicity 900 mg/kg bw/d mouse dermal subchronic repeated dose toxicity p.27
Regulatory source repeated dose toxicity 900 mg/kg bw/d rat inhalation 13 weeks repeated dose toxicity p.27
Regulatory source repeated dose toxicity 1000 mg/kg rat inhalation 9 days repeated dose toxicity p.27
Regulatory source repeated dose toxicity 1500 mg/kg bw/day mouse dermal subchronic repeated dose toxicity p.27
Regulatory source reproductive toxicity 30 mg/kg bw/d rabbit - 3 day reproductive toxicity p.56
Regulatory source reproductive toxicity 100 mg/kg bw/day rat oral - reproductive toxicity p.55
Regulatory source reproductive toxicity 200 ppm rat - developmental reproductive toxicity p.49
Regulatory source reproductive toxicity 720 mg/kg bw/day rat oral developmental reproductive toxicity p.47
COSMOS DB 24 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 46 mg/kg bw/day rat oral 91 day Subchronic REACH; NTP TR 26
COSMOS DB LOAEL 615 mg/kg bw/day mouse oral 90 day Subchronic REACH; NTP TR 26
COSMOS DB NOAEL 82 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 100 mg/kg bw/day rat oral 3 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 125 mg/kg bw/day rat oral 12 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 150 mg/kg bw/day rat oral 3 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 159 mg/kg bw/day rat oral 42 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 222 mg/kg bw/day mouse oral 42 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 225 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 246 mg/kg bw/day rat oral 63 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 250 mg/kg bw/day rat oral 1 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 265 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 297 mg/kg bw/day mouse oral 90 day Subchronic REACH; NTP TR 26
COSMOS DB NOAEL 400 mg/kg bw/day mouse oral 5 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 443 mg/kg bw/day rat oral 60 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 500 mg/kg bw/day mouse oral 36 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 591 mg/kg bw/day rat oral 1 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 627 mg/kg bw/day mouse oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 676 mg/kg bw/day mouse oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 700 mg/kg bw/day mouse oral NA Multigeneration Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1000 mg/kg bw/day mouse oral 35 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1180 mg/kg bw/day mouse oral NA Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1223 mg/kg bw/day mouse oral 96 day Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1379 mg/kg bw/day mouse oral 105 day Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA LOAEL =9.5 mg/kg bw/day Unspecified - - - EFSA CEF - 2011 - OutputID 2100 - hemopoietic - Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - doi:10.2903/j.efsa.2011.2164
EFSA LOAEL =69 mg/kg bw/day Rat - - subchronic EFSA AFC - 2009 - OutputID 2306 - haematology - hemopoietic - Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1) Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - doi:10.2903/j.efsa.2009.934
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 2004 IARC Monographs -
WHO/JECFA 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
WHO/JECFA LOAEL =25 ppm - inhalation subchronic Chronic toxicity document_id=cicads_cicads_cicad10; title=Butoxyethanol, 2- (CICADS); path=mirror/documents/cicads/cicads/cicad10.htm; row_hash=7f4da8a9f4499344; raw_unit=ppm; context=In the subchronic inhalation study, the NOAEL and LOAEL were 25 ppm (121 mg/m 3 ) and 77 ppm (372 mg/m 3 ), respectively (Dodd et al., 1983).
WHO/JECFA LOAEL =50 ppm - - - Developmental toxicity document_id=cicads_cicads_cicad10; title=Butoxyethanol, 2- (CICADS); path=mirror/documents/cicads/cicads/cicad10.htm; row_hash=1d76439ea0fe127d; raw_unit=ppm; context=In the developmental study, the NOAEL and LOAEL in the dams were 50 ppm (242 mg/m 3 ) and 100 ppm (483 mg/m 3 ), respectively (Tyl et al., 1984).
WHO/JECFA LOAEL =77 ppm - - - Chronic toxicity document_id=cicads_cicads_cicad10; title=Butoxyethanol, 2- (CICADS); path=mirror/documents/cicads/cicads/cicad10.htm; row_hash=5642aa24c76d5d24; raw_unit=ppm; context=LOAEL = 77 ppm [372 mg/m 3 ]) in animals exposed subchronically (Dodd et al., 1983); and decreased red blood cells and increased mean cell volume (NOAEL = 50 ppm [242 mg/m 3 ];
WHO/JECFA LOAEL =100 ppm - - - Toxicology study document_id=cicads_cicads_cicad10; title=Butoxyethanol, 2- (CICADS); path=mirror/documents/cicads/cicads/cicad10.htm; row_hash=c267ed97fb705254; raw_unit=ppm; context=LOAEL = 100 ppm [483 mg/m 3 ]) in pregnant animals exposed on days 6-15 of gestation (Tyl et al., 1984).
WHO/JECFA NOAEL =20 ppm - - - Toxicology study document_id=cicads_cicads_cicad10; title=Butoxyethanol, 2- (CICADS); path=mirror/documents/cicads/cicads/cicad10.htm; row_hash=be14728ef1fa82a4; raw_unit=ppm; context=The no-observed-adverse- effect level (NOAEL) in this study is 20 ppm (97 mg/m 3 ).
WHO/JECFA NOAEL =25 ppm - - - Toxicology study document_id=cicads_cicads_cicad10; title=Butoxyethanol, 2- (CICADS); path=mirror/documents/cicads/cicads/cicad10.htm; row_hash=795d7ed3109b538f; raw_unit=ppm; context=The NOAEL in this study is 25 ppm (121 mg/m 3 ).
WHO/JECFA NOAEL =50 ppm - - - Toxicology study document_id=cicads_cicads_cicad10; title=Butoxyethanol, 2- (CICADS); path=mirror/documents/cicads/cicads/cicad10.htm; row_hash=ae18d7c6be2af39f; raw_unit=ppm; context=The NOAEL in this study is 50 ppm (242 mg/m 3 ) 2-butoxyethanol.
NTP ICE acute inhalation 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 range1 mg/L - Inhalation Duration=3 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=937; Record_ID=acute_inhalation_2920; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1024097; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=range; Response=>1 and 4<; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/3/3/?documentUUID=32b82222-1aaa-4c34-98a7-bd7d66a96c4e; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE acute inhalation LC50 2.1737 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=942; Record_ID=acute_inhalation_1117; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1024097; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.1737; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE acute inhalation LC50 2.5263 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=944; Record_ID=acute_inhalation_2471; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1024097; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.5263; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/3/3/?documentUUID=6f3d6ee2-17a8-4932-a3a3-6e83f7082fb0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE acute inhalation LC50 2.6326 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=945; Record_ID=acute_inhalation_2473; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1024097; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.6326; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/3/3/?documentUUID=6f3d6ee2-17a8-4932-a3a3-6e83f7082fb0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE acute inhalation LC50 2.9 mg/L - Inhalation Duration=7 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=940; Record_ID=acute_inhalation_1635; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1024097; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.9; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE acute inhalation LC50 3.8643 mg/L - Inhalation Duration=8 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=939; Record_ID=acute_inhalation_2480; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1024097; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=3.8643; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/3/3/?documentUUID=d09bf766-8c2c-48f0-9caa-60c423f512ff; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE acute inhalation LC50 >4.26 mg/L - Inhalation Duration=7 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=943; Record_ID=acute_inhalation_2481; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1024097; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=4.26; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/3/3/?documentUUID=1eeb89a5-a642-4434-ad2e-723c5afaf971; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE acute inhalation LC50 4.3473 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=936; Record_ID=acute_inhalation_2474; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1024097; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=4.3473; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/3/3/?documentUUID=175889e8-9a39-4c77-b6c6-bcd3fb1876ed; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE acute oral 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =470 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1062; row=2464; data_type=In Vivo; mixture=Chemical; chemical_name=2-Butoxyethanol; preferred_name=2-Butoxyethanol; dtxsid=DTXSID1024097; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1024097; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 >560 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity record_id=acute_oral_1063; row=2463; data_type=In Vivo; mixture=Chemical; chemical_name=2-Butoxyethanol; preferred_name=2-Butoxyethanol; dtxsid=DTXSID1024097; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1024097; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =615 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_1064; row=2462; data_type=In Vivo; mixture=Chemical; chemical_name=2-Butoxyethanol; preferred_name=2-Butoxyethanol; dtxsid=DTXSID1024097; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1024097; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =880 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_1065; row=2460; data_type=In Vivo; mixture=Chemical; chemical_name=2-Butoxyethanol; preferred_name=2-Butoxyethanol; dtxsid=DTXSID1024097; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1024097; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =1480 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_1066; row=2461; data_type=In Vivo; mixture=Chemical; chemical_name=2-Butoxyethanol; preferred_name=2-Butoxyethanol; dtxsid=DTXSID1024097; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1024097; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =1746 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_1067; row=2459; data_type=In Vivo; mixture=Chemical; chemical_name=2-Butoxyethanol; preferred_name=2-Butoxyethanol; dtxsid=DTXSID1024097; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1024097; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 <3000 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity record_id=acute_oral_1068; row=2458; data_type=In Vivo; mixture=Chemical; chemical_name=2-Butoxyethanol; preferred_name=2-Butoxyethanol; dtxsid=DTXSID1024097; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1024097; source_file=acute_oral.xlsx
NTP ICE adme parameters 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 4.299 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=557; Record_ID=adme_parameters_1134; Data_Type=Measured; DTXSID=DTXSID1024097; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=4.299; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE adme parameters Clint 6.691 uL/min/10^6 cells Rat - - Measured; httk, Rat Hepatic Intrinsic Clearance sheet=Data; excel_row=560; Record_ID=adme_parameters_1134; Data_Type=Measured; DTXSID=DTXSID1024097; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=6.691; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE adme parameters Fu 0.5544 fraction Rat - - Measured; httk, Rat Plasma Fraction Unbound sheet=Data; excel_row=559; Record_ID=adme_parameters_1134; Data_Type=Measured; DTXSID=DTXSID1024097; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.5544; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE adme parameters Fu 0.8332 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=558; Record_ID=adme_parameters_1134; Data_Type=Measured; DTXSID=DTXSID1024097; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.8332; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE cancer 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=1826; Record_ID=cancer_5726; Data_Type=WOE; Formulation_Name=2-Butoxyethanol; Mixture=Chemical; DTXSID=DTXSID1024097; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/106; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE cancer POLY-3 lowest dose 1208.34355828221 mg/m3/day Mouse Inhalation - In Vivo; Two year cancer bioassay sheet=Data; excel_row=1814; Record_ID=cancer_5724; Data_Type=In Vivo; Formulation_Name=2-Butoxyethanol (ethylene glycol monobutyl ether); Mixture=Chemical; DTXSID=DTXSID1024097; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=1208.3435582822087; Response_Unit=mg/m3/day; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Inhalation; Level_of_Evidence=Some evidence; Tissue=Forestomach; Lesion=Squamous cell carcinoma or papilloma squamous; Reference=TR-484; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr484/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE cancer Top dose 125 ppm Rat Inhalation - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=1819; Record_ID=cancer_5730; Data_Type=In Vivo; Formulation_Name=2-Butoxyethanol (Ethylene Glycol Monobutyl Ether); Mixture=Chemical; DTXSID=DTXSID1024097; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=125; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Route=Inhalation; Reference=TR-484; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr484/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE cancer Top dose 250 ppm Mouse Inhalation - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=1816; Record_ID=cancer_5723; Data_Type=In Vivo; Formulation_Name=2-Butoxyethanol (Ethylene Glycol Monobutyl Ether); Mixture=Chemical; DTXSID=DTXSID1024097; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=250; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Inhalation; Reference=TR-484; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr484/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=2200; RecordID=ARPathway2016_577; DatasetName=ARPathway2016; DTXSID=DTXSID1024097; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE eye irritation 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE eye irritation Draize rabbit irritation score 68.7 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=500; Record_ID=eye_irritation_162; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID1024097; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=68.7; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE eye irritation EPA Classification 2 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=505; Record_ID=eye_irritation_41; Data_Type=In Vivo; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024097; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE eye irritation GHS Classification 1 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=507; Record_ID=eye_irritation_41; Data_Type=In Vivo; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1024097; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE eye irritation Intensity 0.48 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=502; Record_ID=eye_irritation_1299; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1024097; Assay=Vitrigel; Endpoint=Intensity; Response=0.48; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE eye irritation Lag time 0 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=501; Record_ID=eye_irritation_1299; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1024097; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
NTP ICE eye irritation Plateau level 58 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=503; Record_ID=eye_irritation_1299; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1024097; Assay=Vitrigel; Endpoint=Plateau level; Response=58; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024097; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024097
SCCS Opinion 38 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.05 % rat oral subchronic repeated dose toxicity p.23
SCCS Opinion NOAEL =0.25 % - oral - NOAEL study p.21
SCCS Opinion NOAEL =0.5 % rat - 90 days NOAEL study p.21
SCCS Opinion NOAEL =1 - rat - developmental developmental toxicity p.53
SCCS Opinion NOAEL =1.11 mg/kg bw rat dermal - dermal absorption p.54
SCCS Opinion NOAEL =23 - - - - NOAEL study p.23
SCCS Opinion NOAEL =24 - - - - NOAEL study p.24
SCCS Opinion NOAEL =27 - - - - NOAEL study p.27
SCCS Opinion NOAEL =30 mg/kg bw/day - - - NOAEL study p.48
SCCS Opinion NOAEL =30 mg/kg bw rat dermal - dermal absorption p.54
SCCS Opinion NOAEL =30 mg/kg bw/d rabbit - 3 day reproductive toxicity p.56
SCCS Opinion NOAEL >50 ppm guinea pig dermal - irritation p.14
SCCS Opinion NOAEL =76 - - - 90 days NOAEL study p.23
SCCS Opinion NOAEL =82 mg/kg bw/day rat oral 13 weeks NOAEL study p.23
SCCS Opinion NOAEL =95 µg/cm rat dermal - dermal absorption p.54
SCCS Opinion NOAEL =97 % rat - developmental developmental toxicity p.49
SCCS Opinion NOAEL =99 % rat oral - NOAEL study p.21
SCCS Opinion NOAEL =100 mg/kg mouse oral developmental developmental toxicity p.48
SCCS Opinion NOAEL =100 mg/kg bw/day rat - developmental developmental toxicity p.49
SCCS Opinion NOAEL =129 mg/kg bw/d rat - - NOAEL study p.23
SCCS Opinion NOAEL =150 mg/kg - - - NOAEL study p.5
SCCS Opinion NOAEL =150 mg/kg bw/d rat oral 13 weeks NOAEL study p.23
SCCS Opinion NOAEL =200 ppm rat - developmental reproductive toxicity p.49
SCCS Opinion NOAEL =222 mg/kg rat oral 90 days NOAEL study p.21
SCCS Opinion NOAEL =222 - - oral 6 weeks irritation p.23
SCCS Opinion NOAEL =300 mg/kg bw/day mouse oral developmental developmental toxicity p.48
SCCS Opinion NOAEL =310 mg/kg bw/d rat - 6 days NOAEL study p.21
SCCS Opinion NOAEL =350 mg/kg bw/day mouse oral developmental developmental toxicity p.48
SCCS Opinion NOAEL =370 mg/kg bw rat oral subchronic repeated dose toxicity p.23
SCCS Opinion NOAEL =370 mg/kg bw/d rat oral 13 weeks irritation p.24
SCCS Opinion NOAEL =450 mg/kg rabbit - 14-day NOAEL study p.26
SCCS Opinion NOAEL =450 mg/kg bw/d rat inhalation 4 days repeated dose toxicity p.27
SCCS Opinion NOAEL =650 mg/kg bw/day mouse oral developmental developmental toxicity p.48
SCCS Opinion NOAEL =720 mg/kg bw/day rat oral developmental reproductive toxicity p.47
SCCS Opinion NOAEL =900 mg/kg bw/d mouse dermal subchronic repeated dose toxicity p.27
SCCS Opinion NOAEL =1000 mg/kg bw rabbit dermal 9 days irritation p.25
SCCS Opinion NOAEL =1000 mg/kg rat inhalation 9 days repeated dose toxicity p.27
SCCS Opinion NOAEL =1500 mg/kg bw/day mouse dermal subchronic repeated dose toxicity p.27
EPA ToxRefDB v3 27 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EPA ToxRefDB v3 LEL =1.55 mg/kg bw/day rat (fischer; Fischer 344) inhalation 0 week to 14 week SUB study_id=5092; toxval_study_source_id=studyid5092_Adult_F0_F_systemic; toxval_effect_list=hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-hematocrit (hct)-hematocrit (hct)|hematology-anemia-anemia - nos|hematology-nucleated red blood cell (nrbc)-nucleated red blood cell (nrbc)|pathology microscopic-spleen-hematopoietic cell proliferation erythrocytic|pathology microscopic-liver-pigmentation|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|pathology microscopic-bone marrow-hyperplasia|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|in life observation-clinical signs-lethargy|in life observation-clinical signs-nasal discharge|in life observation-clinical signs-lacrimation|in life observation-clinical signs-ocular discharge|hematology-reticulocyte-reticulocyte|in life observation-clinical signs-labored respiration|in life observation-clinical signs-general pallor|hematology-platelet-platelet|organ weight-kidney-nos|in life observation-clinical signs-salivation|organ weight-liver-nos|in life observation-clinical signs-urogenital staining|in life observation-mortality-mortality|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-necrosis|pathology microscopic-liver-thrombosis|pathology microscopic-heart-thrombosis|organ weight-thymus-nos|pathology microscopic-nose-thrombosis|in life observation-clinical signs-tooth-degeneration|pathology microscopic-thymus-atrophy|pathology microscopic-stomach-ulcer|in life observation-clinical signs-scabbing|in life observation-clinical signs-[other]|hematology-microcytosis-microcytosis|pathology microscopic-kidney-degeneration|pathology microscopic-spleen-atrophy|in life observation-body weight-body weight|pathology microscopic-bone-thrombosis|pathology microscopic-bone-infarct|in life observation-clinical signs-tooth-thrombosis|in life observation-body weight-body weight gain|pathology microscopic-stomach-inflammation|hematology-erythroblast-erythroblast|pathology microscopic-liver-degeneration|in life observation-clinical signs-self-mutilation|pathology microscopic-bone marrow-necrosis|pathology microscopic-liver-necrosis|pathology microscopic-lung-thrombosis; dose_level=1; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =1.56 mg/kg bw/day rat (fischer; Fischer 344) inhalation 0 week to 104 week CHR study_id=5094; toxval_study_source_id=studyid5094_Adult_F0_F_systemic; toxval_effect_list=hematology-[other]-[other]|hematology-reticulocyte-reticulocyte|hematology-anemia-anemia - nos|hematology-hematocrit (hct)-hematocrit (hct)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|hematology-myeloid/erythroid (m:e) ratio-myeloid/erythroid (m:e) ratio|pathology microscopic-nose-degeneration|pathology microscopic-liver-pigmentation|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-bone marrow-hypercellularity|in life observation-body weight-body weight|pathology microscopic-adrenal gland-hyperplasia; dose_level=1; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_2 year study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =4.65 mg/kg bw/day mouse (b6c3f1; B6C3F1) inhalation 0 week to 14 week SUB study_id=5093; toxval_study_source_id=studyid5093_Adult_F0_F_systemic; toxval_effect_list=hematology-anemia-anemia - nos|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-reticulocyte-reticulocyte|hematology-hematocrit (hct)-hematocrit (hct)|pathology microscopic-stomach-hyperplasia|pathology microscopic-spleen-hemosiderosis|pathology microscopic-liver-hemosiderosis|pathology microscopic-stomach-inflammation|hematology-platelet-platelet|in life observation-mortality-mortality|hematology-erythroblast-erythroblast|pathology microscopic-lymph node-atrophy|in life observation-clinical signs-urogenital staining|pathology microscopic-kidney-degeneration|pathology microscopic-stomach-ulcer|pathology microscopic-stomach-necrosis|pathology microscopic-thymus-atrophy|pathology microscopic-pleura-inflammation|organ weight-liver-relative to body weight|in life observation-clinical signs-labored respiration|pathology microscopic-spleen-atrophy|pathology microscopic-kidney-hemosiderosis|pathology microscopic-spleen-hematopoietic cell proliferation|in life observation-clinical signs-lethargy; dose_level=1; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Mice; dsstox_substance_id=DTXSID1024097; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =9.375 mg/kg bw/day mouse (b6c3f1; B6C3F1) inhalation 0 week to 104 week CHR study_id=5095; toxval_study_source_id=studyid5095_Adult_F0_F_systemic; toxval_effect_list=hematology-platelet-platelet|pathology microscopic-stomach-hyperplasia|pathology microscopic-liver-hemosiderosis|pathology microscopic-stomach-ulcer|pathology microscopic-nose-degeneration|hematology-anemia-anemia - nos|pathology microscopic-spleen-hemosiderosis|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|in life observation-body weight-body weight|hematology-hematocrit (hct)-hematocrit (hct)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-neutrophils-neutrophils|hematology-reticulocyte-reticulocyte|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology microscopic-spleen-hematopoietic cell proliferation|pathology microscopic-stomach-squamous cell papilloma; dose_level=1; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_2 year study_Mice; dsstox_substance_id=DTXSID1024097; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =69 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 13 week SUB study_id=5090; toxval_study_source_id=studyid5090_Adult_F0_M_systemic; toxval_effect_list=in life observation-clinical signs-defecation (diarrhea)|pathology microscopic-liver-cytoplasmic alteration|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|clinical chemistry-albumin-albumin|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology microscopic-spleen-pigmentation|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|clinical chemistry-urea nitrogen-urea nitrogen|clinical chemistry-protein-protein|pathology gross-sperm measure-sperm count|hematology-anemia-anemia - macrocytic|pathology microscopic-bone marrow-hyperplasia|pathology microscopic-liver-degeneration|pathology microscopic-spleen-hematopoietic cell proliferation|pathology microscopic-bone marrow-cellular alteration|in life observation-body weight-body weight|in life observation-body weight-body weight gain|organ weight-thymus-absolute|pathology microscopic-blood-thrombocytopenia|in life observation-water consumption-water consumption|pathology microscopic-liver-pigmentation|hematology-reticulocyte-reticulocyte; dose_level=1; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =82 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 13 week SUB study_id=5090; toxval_study_source_id=studyid5090_Adult_F0_F_systemic; toxval_effect_list=hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-anemia-anemia - macrocytic|urinalysis-volume-volume|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|in life observation-clinical signs-defecation (diarrhea)|clinical chemistry-protein-protein|clinical chemistry-urea nitrogen-urea nitrogen|urinalysis-specific gravity/osmolality-specific gravity/osmolality|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|in life observation-water consumption-water consumption|hematology-reticulocyte-reticulocyte|pathology microscopic-liver-pigmentation|pathology microscopic-liver-cytoplasmic alteration|pathology microscopic-spleen-pigmentation|clinical chemistry-creatinine-creatinine|hematology-platelet-platelet|clinical chemistry-albumin-albumin|pathology microscopic-liver-degeneration|clinical chemistry-creatine phosphokinase-creatine phosphokinase|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|pathology microscopic-spleen-hematopoietic cell proliferation|pathology microscopic-bone marrow-hypercellularity|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|pathology microscopic-bone marrow-hyperplasia|in life observation-body weight-body weight gain|in life observation-body weight-body weight|organ weight-thymus-absolute; dose_level=1; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =250 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 14 day SAC study_id=5088; toxval_study_source_id=studyid5088_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|in life observation-body weight-body weight; dose_level=3; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =363 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 13 week SUB study_id=5090; toxval_study_source_id=studyid5090_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-abnormal; dose_level=4; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =400 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 14 day SAC study_id=5089; toxval_study_source_id=studyid5089_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-dehydration; dose_level=4; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Mice; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =553 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 week to 13 week SUB study_id=5091; toxval_study_source_id=studyid5091_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=3; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Mice; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =676 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 week to 13 week SUB study_id=5091; toxval_study_source_id=studyid5091_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=3; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Mice; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LOAEL =3.125 mg/kg bw/day rat (fischer; Fischer 344) inhalation 0 week to 104 week CHR study_id=5094; toxval_study_source_id=studyid5094_Adult_F0_F_systemic; toxval_effect_list=hematology-reticulocyte-reticulocyte|hematology-anemia-anemia - nos|hematology-hematocrit (hct)-hematocrit (hct)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|hematology-myeloid/erythroid (m:e) ratio-myeloid/erythroid (m:e) ratio|hematology-[other]-[other]|pathology microscopic-liver-pigmentation|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc); dose_level=2; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_2 year study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LOAEL =6.25 mg/kg bw/day rat (fischer; Fischer 344) inhalation 0 week to 14 week SUB study_id=5092; toxval_study_source_id=studyid5092_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-lethargy|in life observation-clinical signs-nasal discharge|in life observation-clinical signs-lacrimation|hematology-anemia-anemia - nos|in life observation-clinical signs-ocular discharge|hematology-nucleated red blood cell (nrbc)-nucleated red blood cell (nrbc)|hematology-reticulocyte-reticulocyte|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|in life observation-clinical signs-labored respiration|in life observation-clinical signs-general pallor|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology microscopic-bone marrow-hyperplasia|hematology-platelet-platelet|pathology microscopic-spleen-hematopoietic cell proliferation erythrocytic|organ weight-kidney-nos|hematology-hematocrit (hct)-hematocrit (hct)|in life observation-clinical signs-salivation|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-liver-pigmentation|organ weight-liver-nos|in life observation-clinical signs-urogenital staining; dose_level=3; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LOAEL =18.75 mg/kg bw/day mouse (b6c3f1; B6C3F1) inhalation 0 week to 14 week SUB study_id=5093; toxval_study_source_id=studyid5093_Adult_F0_F_systemic; toxval_effect_list=hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-reticulocyte-reticulocyte|hematology-hematocrit (hct)-hematocrit (hct)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology microscopic-stomach-hyperplasia|hematology-anemia-anemia - nos; dose_level=3; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Mice; dsstox_substance_id=DTXSID1024097; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LOAEL =281 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 13 week SUB study_id=5090; toxval_study_source_id=studyid5090_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-degeneration|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|clinical chemistry-albumin-albumin|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-spleen-hematopoietic cell proliferation|pathology microscopic-bone marrow-cellular alteration|in life observation-body weight-body weight|in life observation-body weight-body weight gain|clinical chemistry-urea nitrogen-urea nitrogen|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|pathology microscopic-spleen-pigmentation|clinical chemistry-protein-protein|pathology microscopic-bone marrow-hyperplasia|hematology-anemia-anemia - macrocytic|pathology microscopic-blood-thrombocytopenia; dose_level=3; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LOAEL =650 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 14 day SAC study_id=5088; toxval_study_source_id=studyid5088_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=5; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL >0 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 13 week SUB study_id=5090; toxval_study_source_id=studyid5090_Adult_F0_F_systemic; toxval_effect_list=pathology gross-uterus-reduced size|clinical chemistry-creatine phosphokinase-creatine phosphokinase|organ weight-thymus-absolute|in life observation-clinical signs-defecation (diarrhea)|urinalysis-specific gravity/osmolality-specific gravity/osmolality|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|in life observation-body weight-body weight gain|in life observation-body weight-body weight|clinical chemistry-creatinine-creatinine|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|in life observation-water consumption-water consumption|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-liver-degeneration|pathology microscopic-bone marrow-hyperplasia|clinical chemistry-albumin-albumin|hematology-platelet-platelet|hematology-anemia-anemia - macrocytic|pathology microscopic-liver-cytoplasmic alteration|urinalysis-volume-volume|pathology microscopic-spleen-pigmentation|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|clinical chemistry-protein-protein|pathology microscopic-spleen-hematopoietic cell proliferation|pathology microscopic-bone marrow-hypercellularity|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-reticulocyte-reticulocyte|pathology microscopic-liver-pigmentation|clinical chemistry-urea nitrogen-urea nitrogen; dose_level=0; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL =150 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 14 day SAC study_id=5088; toxval_study_source_id=studyid5088_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-water consumption-water consumption; dose_level=2; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL =223 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 week to 13 week SUB study_id=5091; toxval_study_source_id=studyid5091_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=2; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Mice; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL =250 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 14 day SAC study_id=5089; toxval_study_source_id=studyid5089_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-dehydration; dose_level=3; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Mice; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL =304 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 13 week SUB study_id=5090; toxval_study_source_id=studyid5090_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-abnormal; dose_level=3; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL =370 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 week to 13 week SUB study_id=5091; toxval_study_source_id=studyid5091_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=2; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Mice; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NOAEL =3.125 mg/kg bw/day rat (fischer; Fischer 344) inhalation 0 week to 14 week SUB study_id=5092; toxval_study_source_id=studyid5092_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-nose-thrombosis|in life observation-clinical signs-ocular discharge|hematology-nucleated red blood cell (nrbc)-nucleated red blood cell (nrbc)|hematology-anemia-anemia - nos|pathology microscopic-thymus-atrophy|pathology microscopic-stomach-ulcer|in life observation-clinical signs-tooth-degeneration|hematology-reticulocyte-reticulocyte|in life observation-clinical signs-scabbing|hematology-microcytosis-microcytosis|in life observation-clinical signs-[other]|pathology microscopic-stomach-necrosis|pathology microscopic-liver-thrombosis|in life observation-clinical signs-lethargy|in life observation-clinical signs-lacrimation|in life observation-clinical signs-nasal discharge|pathology microscopic-heart-thrombosis|organ weight-thymus-nos|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|organ weight-kidney-nos|in life observation-clinical signs-salivation|hematology-hematocrit (hct)-hematocrit (hct)|pathology microscopic-bone marrow-necrosis|hematology-erythroblast-erythroblast|pathology microscopic-liver-degeneration|in life observation-clinical signs-self-mutilation|pathology microscopic-spleen-hematopoietic cell proliferation erythrocytic|organ weight-liver-nos|in life observation-clinical signs-urogenital staining|pathology microscopic-liver-necrosis|pathology microscopic-lung-thrombosis|pathology microscopic-liver-pigmentation|in life observation-clinical signs-labored respiration|in life observation-clinical signs-general pallor|pathology microscopic-spleen-atrophy|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|pathology microscopic-kidney-degeneration|in life observation-mortality-mortality|pathology microscopic-bone-thrombosis|pathology microscopic-bone-infarct|in life observation-body weight-body weight|pathology microscopic-stomach-hyperplasia|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology microscopic-bone marrow-hyperplasia|in life observation-clinical signs-tooth-thrombosis|hematology-platelet-platelet|pathology microscopic-stomach-inflammation|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|in life observation-body weight-body weight gain; dose_level=2; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NOAEL =9.375 mg/kg bw/day mouse (b6c3f1; B6C3F1) inhalation 0 week to 14 week SUB study_id=5093; toxval_study_source_id=studyid5093_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality|pathology microscopic-spleen-hemosiderosis|hematology-erythroblast-erythroblast|pathology microscopic-lymph node-atrophy|pathology microscopic-liver-hemosiderosis|pathology microscopic-stomach-inflammation|hematology-platelet-platelet|pathology microscopic-stomach-hyperplasia|hematology-anemia-anemia - nos|hematology-hematocrit (hct)-hematocrit (hct)|pathology microscopic-kidney-hemosiderosis|pathology microscopic-spleen-hematopoietic cell proliferation|in life observation-clinical signs-lethargy|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology microscopic-thymus-atrophy|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|in life observation-clinical signs-urogenital staining|pathology microscopic-kidney-degeneration|pathology microscopic-stomach-ulcer|pathology microscopic-stomach-necrosis|hematology-reticulocyte-reticulocyte|pathology microscopic-pleura-inflammation|organ weight-liver-relative to body weight|in life observation-clinical signs-labored respiration|pathology microscopic-spleen-atrophy; dose_level=2; study_year=2000; study_citation=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Mice; dsstox_substance_id=DTXSID1024097; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NOAEL =129 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 13 week SUB study_id=5090; toxval_study_source_id=studyid5090_Adult_F0_M_systemic; toxval_effect_list=hematology-reticulocyte-reticulocyte|pathology microscopic-liver-pigmentation|pathology microscopic-bone marrow-hyperplasia|hematology-anemia-anemia - macrocytic|in life observation-water consumption-water consumption|in life observation-clinical signs-defecation (diarrhea)|pathology microscopic-liver-degeneration|pathology microscopic-blood-thrombocytopenia|organ weight-thymus-absolute|pathology gross-sperm measure-sperm count|clinical chemistry-protein-protein|in life observation-body weight-body weight gain|in life observation-body weight-body weight|pathology microscopic-spleen-pigmentation|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|clinical chemistry-urea nitrogen-urea nitrogen|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|clinical chemistry-albumin-albumin|pathology microscopic-spleen-hematopoietic cell proliferation|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-liver-cytoplasmic alteration|pathology microscopic-bone marrow-cellular alteration; dose_level=2; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NOAEL =151 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 13 week SUB study_id=5090; toxval_study_source_id=studyid5090_Adult_F0_F_systemic; toxval_effect_list=hematology-anemia-anemia - macrocytic|urinalysis-volume-volume|pathology microscopic-liver-cytoplasmic alteration|pathology microscopic-spleen-pigmentation|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|clinical chemistry-protein-protein|pathology microscopic-spleen-hematopoietic cell proliferation|pathology microscopic-bone marrow-hypercellularity|hematology-reticulocyte-reticulocyte|hematology-hemoglobin (hgb)-hemoglobin (hgb)|clinical chemistry-urea nitrogen-urea nitrogen|pathology microscopic-liver-pigmentation|pathology gross-uterus-reduced size|clinical chemistry-creatine phosphokinase-creatine phosphokinase|organ weight-thymus-absolute|in life observation-clinical signs-defecation (diarrhea)|in life observation-body weight-body weight gain|in life observation-body weight-body weight|urinalysis-specific gravity/osmolality-specific gravity/osmolality|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|in life observation-water consumption-water consumption|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|clinical chemistry-creatinine-creatinine|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|clinical chemistry-albumin-albumin|hematology-platelet-platelet|pathology microscopic-liver-degeneration|pathology microscopic-bone marrow-hyperplasia; dose_level=2; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NOAEL =400 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 14 day SAC study_id=5088; toxval_study_source_id=studyid5088_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-water consumption-water consumption; dose_level=4; study_year=1993; study_citation=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Rats; dsstox_substance_id=DTXSID1024097; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxValDB ATSDR MRLs 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ATSDR MRLs LOAEL =32 mg/kg bw/day Rat oral short-term; 2 days short-term LONG_REF=Ghanayem BI, Blair PC, Thompson MB, et al. 1987a. Effect of age on the toxicity and metabolism of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Toxicol Appl Pharmacol91(2):222-234.; TITLE=Effect of age on the toxicity and metabolism of ethylene glycol monobutyl ether (2-butoxyethanol) in rats; AUTHOR=Ghanayem BI; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bf1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp118.pdf; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ATSDR MRLs:15447393:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bd1459974a919cc8e307fdce32268645
ToxValDB ATSDR MRLs LOAEL =69 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=NTP. 1993. Ethylene glycol ethers, 2-ethoxyethanoI, 2-butoxyethanol administered in drinking water to F344/N rats and B6C3Fl mice. NTP toxicity report series no. 26. National Toxicology Program, National Institutes of Health, Public Health Services, U.S. Department of Health and Human Services. NIH publication 93-3349.; TITLE=Ethylene glycol ethers, 2-ethoxyethanoI, 2-butoxyethanol administered in drinking water to F344/N rats and B6C3Fl mice; AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bf1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp118.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447394:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_eac2eb0b36287edac2a2a131e61b0b18
ToxValDB ATSDR MRLs MRL =0.07 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=hepatic in male/female rats; STUDY_GROUP=ATSDR MRLs_dup_-_15446901_15446902:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7d1b3e9e1d7a504153633d9dee146257
ToxValDB ATSDR MRLs MRL =0.4 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=hematological in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15446901_15446902:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6c22eb5088ee9708b459307ecae4fec7
ToxValDB ATSDR MRLs MRL =0.96668 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=hematological; STUDY_GROUP=ATSDR MRLs_dup_-_15446898_15446899_15446900:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1d109e770ce3f01f62cc2b8a639e471a
ToxValDB ATSDR MRLs MRL =14.5002 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=hematological in male/female rats; STUDY_GROUP=ATSDR MRLs_dup_-_15446898_15446899_15446900:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_41031068779124e85b8054ee31580f46
ToxValDB ATSDR MRLs MRL =29.0004 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=hematological in female rats; STUDY_GROUP=ATSDR MRLs_dup_-_15446898_15446899_15446900:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_70e677739a8c390f79fbe608f0fff94c
ToxValDB ATSDR MRLs NOAEL =2.90004 mg/m3 Human inhalation chronic; 6 years occupational LONG_REF=Haufroid V, Thirion F, Mertens P, et al. 1997. Biological monitoring of workers exposed to low levels of 2- butoxyethanol. Int Arch Occup Environ Health 70:232-236.; TITLE=Biological monitoring of workers exposed to low levels of 2- butoxyethanol; AUTHOR=Haufroid V; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bf1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp118.pdf; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ATSDR MRLs:15447392:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5f2f0308b3b7d9259306ccfc6f36849f
ToxValDB ATSDR MRLs NOAEL (HEC) =120.835 mg/m3 Rat inhalation subchronic; 90 days subchronic LONG_REF=Dodd DE, Snellings WM, Maronpot RR, et al. 1983. Ethylene glycol monobutyl ether: Acute, 9-day, and 90-day vapor inhalation studies in Fischer 344 rats. Toxicol Appl Pharmacol68(3):405-414.; TITLE=Ethylene glycol monobutyl ether: Acute, 9-day, and 90-day vapor inhalation studies in Fischer 344 rats; AUTHOR=Dodd DE; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bf1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp118.pdf; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ATSDR MRLs_dup_-_15447390_15447391:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5176e7c5c0e3796b8000f4eb43eb8e05
ToxValDB ATSDR MRLs NOAEL (HEC) =241.67 mg/m3 Rat inhalation short-term (developmental); 10 days reproduction developmental LONG_REF=Tyl RW, Millicovsky G, Dodd DE, et al. 1984. Teratologic evaluation of ethylene glycol monobutyl ether in Fischer 344 rats and New Zealand white rabbits following inhalation exposure. Environ Health Perspect 57:47-68.; TITLE=Teratologic evaluation of ethylene glycol monobutyl ether in Fischer 344 rats and New Zealand white rabbits following inhalation exposure; AUTHOR=Tyl RW; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584bf1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp118.pdf; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ATSDR MRLs_dup_-_15447388_15447389:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8af693f227f72aff2a70b90332453526
ToxValDB Cal OEHHA REL derivations 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB Cal OEHHA REL derivations BMCL (05) =39.4 mg/m3 Rat inhalation chronic; 2 years chronic LONG_REF=NTP (2000). Toxicology and carcinogenesis studies 2-butoxyethanol (CAS NO. 111-76- 2) in F344/N rats and B6C3F1 mice (inhalation studies).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9c006e4b02565fc7d970f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/air/crnr/notice-adoption-reference-exposure-levels-ethylene-glycol-mono-n-butyl-ether; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=Hyaline degeneration of nasal olfactory epithelium; STUDY_GROUP=Cal OEHHA REL derivations:15951806:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_96a9638cb2e880e910ebf32a15aee7f6
ToxValDB Cal OEHHA REL derivations LOAEL =473 mg/m3 Human inhalation acute; 8 hours clinical LONG_REF=Carpenter CP, Keck GA, Nair JH, 3rd, Pozzani UC, Smyth HF, Jr. and Weil CS (1956). The toxicity of butyl cellosolve solvent. AMA Arch Ind Health 14(2): 114-31.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9c006e4b02565fc7d970f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/air/crnr/notice-adoption-reference-exposure-levels-ethylene-glycol-mono-n-butyl-ether; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=Subjective ocular and respiratory irritation; STUDY_GROUP=Cal OEHHA REL derivations:15951804:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ebf2debad681a0aa7133e763223a8c9d
ToxValDB Cal OEHHA REL derivations NOAEL =96.668 mg/m3 Human inhalation acute; 4 hours clinical LONG_REF=Carpenter CP, Pozzani UC, Weil CS, Nair JH, Keck GA, Smyth HF Jr. The toxicity of butyl cellosolve solvent. Arch Ind Health 1956;14:114-131. Johanson G, Kronborg H, Naslund PH, Nordquist MB. Toxicokinetics of inhaled 2-butoxyethanol (ethylene glycol monobutyl ether) in man. Scand J Work Environ Health 1986;12:594-602.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=mucous membrane irritation of the nose and eyes; STUDY_GROUP=Cal OEHHA REL derivations:15951926:-:-volunteers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a53fbbac5178056d46b9d0788a5560e6
ToxValDB DOE Protective Action Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB DOE Protective Action Criteria LEL =53167.4 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15513003:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8369290a6ec6fb03d7943009f2dea305
ECHA 41 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL =6283.42 mg/m3 Rat inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/3/3?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15796255_15796256_15796257:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c46a43e1b32f4d56590d5ef76b434454
ECHA LOAEL <82 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b599b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/9/2?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=P0: haematology; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855911_15855973_15856656_15862035:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_461709da85dd7c060508ee8bf5bbd46c
ECHA LOAEL <500 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b599e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/9/2?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855186_15856054:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_36b5a5a507ac9173531950eef564d352
ECHA LOAEL =635 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b562f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12659/7/9/2?documentUUID=c30d6d33-b87a-4514-b028-d4a51400c115; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=P1: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15858213_15861926:M/F:P1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_709346f2cc34fb5c01a83f8fc23be35e
ECHA LOAEL =676 mg/kg bw/day Mouse oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eace1e4b0a7c65d1c15ae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16067/7/6/2?documentUUID=394d78d7-dafb-4a34-81b0-31ac5f525344; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832288_15832289_15838642_15838643:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_acb414f3bccc0cbfcb8798ba552814bb
ECHA LOAEL =720 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b59a0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/9/2?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=P0: water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855789_15856544_15860743_15862020:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3750e188a3fcba349c03f933fe435453
ECHA LOEC ~483.34 mg/m3 Monkey inhalation short-term; 10 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/6/3?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID:15827671:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7fa00be0e29894d4d345aaf16cde2529
ECHA NOAEC >96.668 mg/m3 Rat inhalation short-term; 3 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/6/3?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=blood; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829659_15829660:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_164372a067225aea61e24d893ec711e9
ECHA NOAEC =120.835 mg/m3 Rat inhalation - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c892e4b0a7c65d21937b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/9/2?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID:15856397:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8d67bfe72509e10d235ea9283b3c14ba
ECHA NOAEC <149.835 mg/m3 Rat inhalation chronic; 14 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fc4e4b096bca877ebbe; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12659/7/6/3?documentUUID=c30d6d33-b87a-4514-b028-d4a51400c115; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827038_15828295:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8b7adf5d58b5a91324e35130add909a5
ECHA NOAEC =200 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bbacc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16067/7/9/3?documentUUID=394d78d7-dafb-4a34-81b0-31ac5f525344; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821846_15821900:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_36e494eef852df868f236e45c3300fec
ECHA NOAEC =241.67 mg/m3 Rat inhalation - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d18ae4b0a7c65d22f0d5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/9/3?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID:15820874:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e4655e9b4693c7969b8fdea6a833296e
ECHA NOAEC <261.004 mg/m3 Rat inhalation subchronic; 6 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/6/3?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=blood; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECHA IUCLID:15828431:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0ab07809cb0259f5b732d1053944849d
ECHA NOAEC =302.087 mg/m3 Rat inhalation chronic; 14 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fc4e4b096bca877ebbe; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12659/7/6/3?documentUUID=c30d6d33-b87a-4514-b028-d4a51400c115; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827039_15828296:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e9ffbb6bcccfc53e7c06e0ac90cc325
ECHA NOAEC >372.172 mg/m3 Rat inhalation subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/6/3?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=blood; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECHA IUCLID:15827525:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f3444bfa8901240e230cfec7ef7703ac
ECHA NOAEC >400 mg/kg bw/day Rat oral - subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa35e4b0a7c65d1b4d68; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/10/2?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID:15825485:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b95f494a8ab5b883f854213b6449ea48
ECHA NOAEC >444 mg/kg bw/day Rat oral - subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa35e4b0a7c65d1b4d65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/10/2?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID:15825477:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bb5c6c52e3131ef4c1b0cf4da32acf12
ECHA NOAEC <483.34 mg/m3 Dog inhalation chronic; 91 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/6/3?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID:15829572:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_de7b641348a674f38f9a6000a23de69f
ECHA NOAEC >500 mg/kg bw/day Rat oral - subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa35e4b0a7c65d1b4d65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/10/2?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID:15825476:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_64fe74b8b4b3007fe46b25bd5189aad0
ECHA NOAEC <541.341 mg/m3 Mouse inhalation subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/6/3?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID:15828816:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ebcb6d5e134d7bc7b9faf97400bb1cf7
ECHA NOAEC =604.175 mg/m3 Mouse inhalation - chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c7fce4b0a7c65d215f44; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/8?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816773_15819220:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_927918ecad2a9bc63b3c9463af77fc56
ECHA NOAEC =650 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bba9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/9/3?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=fetus: changes in postnatal survival; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15820847:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6e6834271447a72e962d9bc674e19434
ECHA NOAEC <725.01 mg/m3 Rat inhalation - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d18ae4b0a7c65d22f0e7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/9/3?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=maternal: urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECHA IUCLID:15822607:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_738770005da183328b5f088bb25869b2
ECHA NOAEC >966.68 mg/m3 Rat inhalation - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d18ae4b0a7c65d22f0e7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/9/3?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID:15821288:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b2adf1f3d233a5f3d0f55af3178b0b3d
ECHA NOAEC <1812.52 mg/m3 Guinea Pig inhalation short-term; 30 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/6/3?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID:15829180:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_baeef18434d28f4ec0fc08c30ac3ae01
ECHA NOAEC >2595.53 mg/m3 Guinea Pig inhalation short-term; 15 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/6/3?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID:15827782:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8db8a95891ec807a5aa9f7637448f3d5
ECHA NOAEL =30 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bbacc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16067/7/9/3?documentUUID=394d78d7-dafb-4a34-81b0-31ac5f525344; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: food consumption and compound intake|maternal: haematology|maternal: organ weights and organ / body weight ratios|maternal: water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823678_15823746:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b973e39a89d8bc3f46696d87a81cce20
ECHA NOAEL =129 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b599b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/9/2?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=P0: haematology; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860480_15861639_15861861_15862346:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_02beb09bf3472f2d51df22ee2b395e53
ECHA NOAEL >150 mg/kg bw/day Rabbit dermal subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61ec4e4b096bca877afa4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/6/4?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID:15826635:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_be71a26ebf9a131f00700baa46b3362a
ECHA NOAEL <222 mg/kg bw/day Rat oral subchronic; 6 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eace1e4b0a7c65d1c1504; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/6/2?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=spleen: haematology|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECHA IUCLID:15842971:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_db3df7841fe73fd36536d572757a83cb
ECHA NOAEL =241.67 mg/m3 Rabbit inhalation - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d18ae4b0a7c65d22f0f1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/9/3?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: clinical signs|maternal: mortality|maternal: number of abortions|maternal: pre and post implantation loss; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|mortality/survival|reproduction; STUDY_GROUP=ECHA IUCLID:15822913:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0f12ed5b2b1939a4fce64c6a1b8af2d6
ECHA NOAEL =350 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bba9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/9/3?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=maternal: clinical signs|maternal: haematology; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|hematology; STUDY_GROUP=ECHA IUCLID:15822185:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_459e11a0c9db9799ffd2bedd62920b59
ECHA NOAEL =370 mg/kg bw/day Mouse oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eace1e4b0a7c65d1c15ae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16067/7/6/2?documentUUID=394d78d7-dafb-4a34-81b0-31ac5f525344; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832288_15832289_15838642_15838643:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_12c7d3126256e87c736b1d5bf865afae
ECHA NOAEL >452 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b599b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/9/2?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=P0: reproductive function (sperm measures); TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860480_15861639_15861861_15862346:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_986999878d112cb9f2e6150d4ada1214
ECHA NOAEL >470 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b61f2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14826/7/9/2?documentUUID=71ba2e45-fbd7-417d-9132-f7c68b1eee7d; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855911_15855973_15856656_15862035:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bdfbaa154e8d4b76e2aab41b9c0535c2
ECHA NOAEL >694 mg/kg bw/day Mouse oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eace1e4b0a7c65d1c15ae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16067/7/6/2?documentUUID=394d78d7-dafb-4a34-81b0-31ac5f525344; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832287_15838641:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3cd7c21fac683218081c18ceb00efb7b
ECHA NOAEL =720 mg/kg bw/day Mouse oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b562f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12659/7/9/2?documentUUID=c30d6d33-b87a-4514-b028-d4a51400c115; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=F1: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15861257_15862190:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7a42aab7bb00d91474ca81dc1b2407d8
ECHA NOAEL =1000 mg/kg bw/day Mouse dermal - subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c851e4b0a7c65d217e58; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/10/2?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID:15825461:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9e6b5e2fa16cd376d7a1f565c66a0a8c
ECHA NOAEL >1306 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b5999; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/9/2?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=P0: reproductive function (oestrous cycle); TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15855882:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f42278df4523ce4f1a638e1e2d6533c2
ECHA NOEC >120 mg/kg bw/day Mouse infusion - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c7fce4b0a7c65d215f58; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/8?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID:15817326:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f35a92fec68acac3a3c76257391a183a
ECHA NOEC >362.505 mg/m3 Rat inhalation - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c892e4b0a7c65d21937b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15247/7/9/2?documentUUID=7556a105-201e-4a94-9184-3d171921724f; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=ECHA IUCLID:15855612:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4b8ceb5679d3e855d653cb53f844fb57
ToxValDB ECOTOX 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =1180 mg/kg bw/day Mouse oral short-term (developmental); 8 days reproduction developmental LONG_REF=Teratog. Carcinog. Mutagen.7:29-48 Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test 1987; TITLE=Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test; AUTHOR=Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=49969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX:15612030:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=2a3c2554516c63d57193b0771d4a5b5a
ToxValDB ECOTOX NOEL =55 mg/kg bw/day Rat injection short-term; 14 days short-term LONG_REF=Toxicol. Lett.45(2/3): 271-280 Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat 1989; TITLE=Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat; AUTHOR=Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys; DOI=10.1016/0378-4274(89)90018-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113042; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: beta2-Microglobulin|Enzyme(s): beta-N-Acetylhexosaminidase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15603492:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3bdce32c5af3d517163f6f1b4fce7797
ToxValDB EPA TSCA 8e 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB EPA TSCA 8e LEL =200 mg/kg bw/day Rat oral short-term; 28 days short-term STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-16-20496_Combined.pdf; TOXICOLOGICAL_EFFECT=increased relative spleen weight; STUDY_GROUP=EPA TSCA 8e:15957175:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dbe1ee5f399ec21e7bf51c9b34bac174
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =98 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630379:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2bc000ac15396d7adf149bbcbccf48e6
ToxValDB HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HESS NOEL <114 mg/kg bw/day Rat oral - subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e16e4b0a676289df68a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Clinical Observation: Diarrhea|Body Weight Changes: decrease|Water Consumption: decrease|Urinalysis: Volume decrease, Specific gravity increase|Hematology: Hct decrease, RBC decrease, MCV increase, MCH decrease, Hgb decrease, Ret increase, Nucleated erythrocytes increase, MCHC decrease, Plt decrease, WBC increase, Seg increase, Lymph increase|Blood Chemistry: BUN increase, Crn increase, TP decrease, Alb decrease, Alp increase, ALT(GPT) increase|Absolute Organ Weight: Thymus decrease|Relative Organ Weight: Right kidney increase|Histopathology: Liver-Cytoplasmic alteration Liver-Degeneration Liver-Pigmentation Bone marrow-Hyperplasiaaf>>4500 Spleen-Hematopoietic cell proliferation Spleen-Pigmentation|Reproductive Tissue Evaluation: Weights-Left epididymis decrease, Spermatozoal measurements-Concentration decrease|Bone Marrow Cellularity Counts: increase; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|multiple|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=HESS:15638227:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_132e08c7f616eb46412a1f025b5c7a41
ToxValDB IRIS 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB IRIS BMCL =133 umol-hour/L Rat inhalation chronic; 2 years chronic LONG_REF=NTP (2000). NTP technical report on the toxicology and carcinogenesis studies of 2 butoxyethanol (CAS No. 111-76-2) in F344/N rats and B6C3F1 mice (inhalation studies). National Toxicology Program. Research Triangle Park, NC. NTP TR 484. http://ntp.niehs.nih.gov/?objectid=070AC403-B110-CA79-3A23AF79DE7B752A. 196296; TITLE=NTP technical report on the toxicology and carcinogenesis studies of 2 butoxyethanol (CAS No. 111-76-2) in F344/N rats and B6C3F1 mice (inhalation studies); AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=500; TOXICOLOGICAL_EFFECT=hemosiderin deposition in the liver; STUDY_GROUP=IRIS:15644836:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0bc350bb6195ee48d4b2ed28a74f19ca
ToxValDB IRIS BMCL (HEC) =16 mg/m3 Rat inhalation chronic; 2 years chronic LONG_REF=NTP (2000). NTP technical report on the toxicology and carcinogenesis studies of 2 butoxyethanol (CAS No. 111-76-2) in F344/N rats and B6C3F1 mice (inhalation studies). National Toxicology Program. Research Triangle Park, NC. NTP TR 484. http://ntp.niehs.nih.gov/?objectid=070AC403-B110-CA79-3A23AF79DE7B752A. 196296; TITLE=NTP technical report on the toxicology and carcinogenesis studies of 2 butoxyethanol (CAS No. 111-76-2) in F344/N rats and B6C3F1 mice (inhalation studies); AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=500; TOXICOLOGICAL_EFFECT=hemosiderin deposition in the liver; STUDY_GROUP=IRIS:15644833:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_89acf2efbd28a270302555a8bc2c405a
ToxValDB IRIS BMDL =133 umol-hour/L Rat oral chronic; 2 years chronic LONG_REF=NTP (2000). NTP technical report on the toxicology and carcinogenesis studies of 2 butoxyethanol (CAS No. 111-76-2) in F344/N rats and B6C3F1 mice (inhalation studies). National Toxicology Program. Research Triangle Park, NC. NTP TR 484. http://ntp.niehs.nih.gov/?objectid=070AC403-B110-CA79-3A23AF79DE7B752A. 196294; TITLE=NTP technical report on the toxicology and carcinogenesis studies of 2 butoxyethanol (CAS No. 111-76-2) in F344/N rats and B6C3F1 mice (inhalation studies); AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=500; TOXICOLOGICAL_EFFECT=hemosiderin deposition in the liver; STUDY_GROUP=IRIS:15644539:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_030dc47ad5725d38e65b9e5b90401de3
ToxValDB IRIS BMDL (HED) =1.4 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=NTP (2000). NTP technical report on the toxicology and carcinogenesis studies of 2 butoxyethanol (CAS No. 111-76-2) in F344/N rats and B6C3F1 mice (inhalation studies). National Toxicology Program. Research Triangle Park, NC. NTP TR 484. http://ntp.niehs.nih.gov/?objectid=070AC403-B110-CA79-3A23AF79DE7B752A. 196295; TITLE=NTP technical report on the toxicology and carcinogenesis studies of 2 butoxyethanol (CAS No. 111-76-2) in F344/N rats and B6C3F1 mice (inhalation studies); AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=500; TOXICOLOGICAL_EFFECT=hemosiderin deposition in the liver; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS:15644538:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8de9f13d4472224bf07b15958ba356ae
ToxValDB IRIS RfC =1.6 mg/m3 Human inhalation - Toxicity Value LONG_REF=NTP (2000); AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=500; TOXICOLOGICAL_EFFECT=Hemosiderin deposition in male/female rats; STUDY_GROUP=IRIS:15644834:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6f01f79936080b1976dbc0494d2986fd
ToxValDB IRIS RfD =0.1 mg/kg bw/day Human oral - Toxicity Value LONG_REF=NTP (2000); AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=500; TOXICOLOGICAL_EFFECT=Hemosiderin deposition in male/female rats; STUDY_GROUP=IRIS:15644832:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a757652a54fd6b33aacc50be96430189
ToxValDB RSL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB RSL RfC =14.5006 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663454:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_588461569d3355dc515e4437b2be27d8
ToxValDB TX TCEQ 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB TX TCEQ LOAEL =31 ppm Rat - chronic chronic LONG_REF=National Toxicology Program (NTP). 1998: Toxicology and carcinogenesis studies of 2butoxyethanol (CAS No. 111-76-2) in F344/N rats and B6C3F1 mice (Inhalation Studies). Board Draft NTP TR 484. [Peer Review Date: October 30, 1998]. NTP, Research Triangle Park, NC. U.S. Environmental Protection Agency (USEPA). 1999. Toxicological review of ethylene glycol monobutyl ether (EGBE). USEAP, Washington, DC; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b33; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/butoxyethanol-2.pdf; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=hematological effects; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=TX TCEQ:15954267:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_db97b60a3447a0fd962df55ed847fe5f
ToxValDB TX TCEQ NOAEL =20 ppm Human - acute; 2 hours clinical LONG_REF=Johason, G, H Kronborg , PH Naslund, et al. 1986a. Toxicokinetics of inhaled 2-butoxyethanol (ethylene glycol monobutyl ether) in man. Scand J Work Environ Health 12:594-602.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b33; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/butoxyethanol-2.pdf; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Respiratory effects, sensory irritation; STUDY_GROUP=TX TCEQ:15954269:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e6888e6293c2d2229f0e27d11c898e9f
ToxValDB ToxRefDB 21 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ToxRefDB LEL =1.55 mg/kg bw/day Rat inhalation chronic; 14 weeks chronic LONG_REF=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Rats; TITLE=Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5092; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-anemia-anemia - nos|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: hematology-nucleated red blood cell (nrbc)-nucleated red blood cell (nrbc)|systemic: pathology microscopic-spleen-hematopoietic cell proliferation erythrocytic|systemic: pathology microscopic-bone marrow-hyperplasia|systemic: pathology microscopic-liver-pigmentation|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: in life observation-clinical signs-lethargy|systemic: organ weight-kidney-nos|systemic: in life observation-clinical signs-salivation|systemic: in life observation-clinical signs-labored respiration|systemic: in life observation-clinical signs-general pallor|systemic: in life observation-clinical signs-ocular discharge|systemic: hematology-reticulocyte-reticulocyte|systemic: in life observation-clinical signs-nasal discharge|systemic: in life observation-clinical signs-lacrimation|systemic: organ weight-liver-nos|systemic: in life observation-clinical signs-urogenital staining|systemic: hematology-platelet-platelet|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology microscopic-kidney-degeneration|systemic: pathology microscopic-spleen-atrophy|systemic: pathology microscopic-nose-thrombosis|systemic: pathology microscopic-stomach-necrosis|systemic: in life observation-clinical signs-tooth-degeneration|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-bone-thrombosis|systemic: pathology microscopic-bone-infarct|systemic: pathology microscopic-thymus-atrophy|systemic: pathology microscopic-stomach-ulcer|systemic: hematology-erythroblast-erythroblast|systemic: pathology microscopic-liver-degeneration|systemic: in life observation-clinical signs-self-mutilation|systemic: pathology microscopic-bone marrow-necrosis|systemic: pathology microscopic-liver-thrombosis|systemic: pathology microscopic-heart-thrombosis|systemic: in life observation-clinical signs-scabbing|systemic: in life observation-clinical signs-tooth-thrombosis|systemic: in life observation-clinical signs-[other]|systemic: organ weight-thymus-nos|systemic: in life observation-body weight-body weight gain|systemic: hematology-microcytosis-microcytosis|systemic: pathology microscopic-stomach-inflammation|systemic: pathology microscopic-liver-necrosis|systemic: pathology microscopic-lung-thrombosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708492_15708493_15708494:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_97ab22755d015472b42b0007f328988c
ToxValDB ToxRefDB LEL =1.56 mg/kg bw/day Rat inhalation chronic; 104 weeks chronic LONG_REF=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_2 year study_Rats; TITLE=Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_2 year study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5094; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: hematology-[other]-[other]|systemic: hematology-reticulocyte-reticulocyte|systemic: pathology microscopic-liver-pigmentation|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: hematology-myeloid/erythroid (m:e) ratio-myeloid/erythroid (m:e) ratio|systemic: hematology-anemia-anemia - nos|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: pathology microscopic-nose-degeneration|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-adrenal gland-hyperplasia|systemic: pathology microscopic-bone marrow-hypercellularity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708506_15708507_15708508:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9d9ee4c748f17c82145430d4ceb4e0c2
ToxValDB ToxRefDB LEL =4.65 mg/kg bw/day Mouse inhalation chronic; 14 weeks chronic LONG_REF=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Mice; TITLE=Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5093; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-anemia-anemia - nos|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-reticulocyte-reticulocyte|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology microscopic-spleen-hemosiderosis|systemic: pathology microscopic-stomach-inflammation|systemic: pathology microscopic-liver-hemosiderosis|systemic: hematology-platelet-platelet|systemic: in life observation-clinical signs-urogenital staining|systemic: pathology microscopic-kidney-hemosiderosis|systemic: pathology microscopic-kidney-degeneration|systemic: pathology microscopic-stomach-ulcer|systemic: pathology microscopic-stomach-necrosis|systemic: pathology microscopic-thymus-atrophy|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-pleura-inflammation|systemic: organ weight-liver-relative to body weight|systemic: in life observation-clinical signs-labored respiration|systemic: pathology microscopic-spleen-atrophy|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: hematology-erythroblast-erythroblast|systemic: in life observation-clinical signs-lethargy|systemic: pathology microscopic-lymph node-atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|hematology|mortality/survival|nonneoplastic histopathology|organ weight|other; STUDY_GROUP=ToxRefDB_dup_-_15708499_15708500_15708501:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_973b622a76d689136e39e77010af75c1
ToxValDB ToxRefDB LEL =82 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; TITLE=Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5090; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-defecation (diarrhea)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-anemia-anemia - macrocytic|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: urinalysis-volume-volume|systemic: in life observation-water consumption-water consumption|systemic: clinical chemistry-protein-protein|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: urinalysis-specific gravity/osmolality-specific gravity/osmolality|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: clinical chemistry-creatine phosphokinase-creatine phosphokinase|systemic: clinical chemistry-creatinine-creatinine|systemic: hematology-reticulocyte-reticulocyte|systemic: hematology-platelet-platelet|systemic: pathology microscopic-liver-pigmentation|systemic: clinical chemistry-albumin-albumin|systemic: pathology microscopic-liver-cytoplasmic alteration|systemic: pathology microscopic-liver-degeneration|systemic: pathology microscopic-spleen-pigmentation|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: pathology microscopic-bone marrow-hypercellularity|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-bone marrow-hyperplasia|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: organ weight-thymus-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708478_15708479_15708480:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0ac6ce3315e8c1bf964e27e679a6c098
ToxValDB ToxRefDB LEL =250 mg/kg bw/day Rat oral short-term; 14 days short-term LONG_REF=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Rats; TITLE=Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5088; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15708466_15708467_15708468_15708469:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d8de71f49127f1d0fceaa3e4c90bb9a5
ToxValDB ToxRefDB LEL =363 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; TITLE=Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5090; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-estrous cycle-abnormal; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15708476_15708477:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cbef7444314422811c347c4675bcc773
ToxValDB ToxRefDB LEL =400 mg/kg bw/day Mouse oral short-term; 14 days short-term LONG_REF=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Mice; TITLE=Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5089; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-dehydration; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15708472_15708473:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_17751f9c1985a02d1023550eb8bb4fdd
ToxValDB ToxRefDB LEL =553 mg/kg bw/day Mouse oral subchronic; 13 weeks subchronic LONG_REF=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Mice; TITLE=Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5091; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15708488_15708489_15708490_15708491:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9c72420cee00f27d0f0828b333a43c30
ToxValDB ToxRefDB LOAEL =6.25 mg/kg bw/day Rat inhalation chronic; 14 weeks chronic LONG_REF=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Rats; TITLE=Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5092; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: hematology-anemia-anemia - nos|systemic: pathology microscopic-spleen-hematopoietic cell proliferation erythrocytic|systemic: in life observation-clinical signs-lethargy|systemic: organ weight-kidney-nos|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: in life observation-clinical signs-salivation|systemic: in life observation-clinical signs-labored respiration|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: in life observation-clinical signs-general pallor|systemic: in life observation-clinical signs-ocular discharge|systemic: hematology-nucleated red blood cell (nrbc)-nucleated red blood cell (nrbc)|systemic: pathology microscopic-liver-pigmentation|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-reticulocyte-reticulocyte|systemic: in life observation-clinical signs-nasal discharge|systemic: in life observation-clinical signs-lacrimation|systemic: organ weight-liver-nos|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: pathology microscopic-bone marrow-hyperplasia|systemic: in life observation-clinical signs-urogenital staining|systemic: hematology-platelet-platelet; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708492_15708493_15708494:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fb80299fc46c41e8388d8fe4f217e8f0
ToxValDB ToxRefDB LOAEL =18.75 mg/kg bw/day Mouse inhalation chronic; 14 weeks chronic LONG_REF=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Mice; TITLE=Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5093; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-reticulocyte-reticulocyte|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: pathology microscopic-stomach-hyperplasia|systemic: hematology-anemia-anemia - nos; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708499_15708500_15708501:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7366c4ddfd2694183de1a4bb8571232b
ToxValDB ToxRefDB LOAEL =281 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; TITLE=Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5090; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-degeneration|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: clinical chemistry-albumin-albumin|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: clinical chemistry-protein-protein|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-bone marrow-hyperplasia|systemic: in life observation-body weight-body weight gain|systemic: hematology-anemia-anemia - macrocytic|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: pathology microscopic-spleen-pigmentation|systemic: pathology microscopic-bone marrow-cellular alteration|systemic: pathology microscopic-blood-thrombocytopenia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708481_15708482_15708483:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5008b9f742c4bd562abcb25579ce9ecf
ToxValDB ToxRefDB LOAEL =650 mg/kg bw/day Rat oral short-term; 14 days short-term LONG_REF=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Rats; TITLE=Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5088; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15708466_15708467_15708468_15708469:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8879e649eb771dd06e1d307cf61e7d51
ToxValDB ToxRefDB NEL =150 mg/kg bw/day Rat oral short-term; 14 days short-term LONG_REF=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Rats; TITLE=Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5088; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15708466_15708467_15708468_15708469:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d4a3f2cd21a488400c022f059b5e84ff
ToxValDB ToxRefDB NEL =223 mg/kg bw/day Mouse oral subchronic; 13 weeks subchronic LONG_REF=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Mice; TITLE=Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5091; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15708488_15708489_15708490_15708491:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bc890a3b3e1141265ceba4efb83a92d8
ToxValDB ToxRefDB NEL =250 mg/kg bw/day Mouse oral short-term; 14 days short-term LONG_REF=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Mice; TITLE=Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5089; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-dehydration; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15708472_15708473:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d691fed51c6c8c9c3a856c876a19e085
ToxValDB ToxRefDB NEL =304 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; TITLE=Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5090; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-estrous cycle-abnormal; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15708476_15708477:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f586ef9f5998caba3a9cb03f1b617102
ToxValDB ToxRefDB NOAEL =3.125 mg/kg bw/day Rat inhalation chronic; 14 weeks chronic LONG_REF=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Rats; TITLE=Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5092; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: in life observation-clinical signs-labored respiration|systemic: pathology microscopic-nose-thrombosis|systemic: in life observation-clinical signs-general pallor|systemic: pathology microscopic-stomach-necrosis|systemic: organ weight-kidney-nos|systemic: pathology microscopic-spleen-atrophy|systemic: in life observation-clinical signs-salivation|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: in life observation-clinical signs-ocular discharge|systemic: hematology-nucleated red blood cell (nrbc)-nucleated red blood cell (nrbc)|systemic: pathology microscopic-kidney-degeneration|systemic: pathology microscopic-bone marrow-necrosis|systemic: pathology microscopic-liver-thrombosis|systemic: hematology-erythroblast-erythroblast|systemic: hematology-anemia-anemia - nos|systemic: pathology microscopic-liver-degeneration|systemic: in life observation-clinical signs-self-mutilation|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-bone-thrombosis|systemic: pathology microscopic-bone-infarct|systemic: pathology microscopic-thymus-atrophy|systemic: in life observation-clinical signs-lethargy|systemic: pathology microscopic-stomach-ulcer|systemic: pathology microscopic-spleen-hematopoietic cell proliferation erythrocytic|systemic: in life observation-clinical signs-tooth-degeneration|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-lacrimation|systemic: organ weight-liver-nos|systemic: pathology microscopic-stomach-hyperplasia|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: pathology microscopic-bone marrow-hyperplasia|systemic: hematology-reticulocyte-reticulocyte|systemic: in life observation-clinical signs-scabbing|systemic: in life observation-clinical signs-nasal discharge|systemic: in life observation-clinical signs-tooth-thrombosis|systemic: pathology microscopic-heart-thrombosis|systemic: in life observation-clinical signs-urogenital staining|systemic: hematology-platelet-platelet|systemic: pathology microscopic-liver-necrosis|systemic: pathology microscopic-lung-thrombosis|systemic: pathology microscopic-stomach-inflammation|systemic: pathology microscopic-liver-pigmentation|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: in life observation-body weight-body weight gain|systemic: hematology-microcytosis-microcytosis|systemic: in life observation-clinical signs-[other]|systemic: organ weight-thymus-nos; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708492_15708493_15708494:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e336fef31bb4394832edf7b79db5790a
ToxValDB ToxRefDB NOAEL =9.375 mg/kg bw/day Mouse inhalation chronic; 14 weeks chronic LONG_REF=NTP_2000_Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Mice; TITLE=Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)_14 week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5093; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: pathology microscopic-thymus-atrophy|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-urogenital staining|systemic: pathology microscopic-kidney-hemosiderosis|systemic: pathology microscopic-stomach-inflammation|systemic: pathology microscopic-kidney-degeneration|systemic: pathology microscopic-stomach-ulcer|systemic: pathology microscopic-spleen-hemosiderosis|systemic: pathology microscopic-stomach-necrosis|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: hematology-platelet-platelet|systemic: hematology-erythroblast-erythroblast|systemic: in life observation-clinical signs-lethargy|systemic: pathology microscopic-lymph node-atrophy|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: pathology microscopic-stomach-hyperplasia|systemic: hematology-anemia-anemia - nos|systemic: hematology-reticulocyte-reticulocyte|systemic: pathology microscopic-pleura-inflammation|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-liver-hemosiderosis|systemic: in life observation-clinical signs-labored respiration|systemic: pathology microscopic-spleen-atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|hematology|mortality/survival|nonneoplastic histopathology|organ weight|other; STUDY_GROUP=ToxRefDB_dup_-_15708499_15708500_15708501:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_99e0e9efd40caddd0eac6145a0c41b76
ToxValDB ToxRefDB NOAEL =129 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; TITLE=Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5090; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: hematology-reticulocyte-reticulocyte|systemic: organ weight-thymus-absolute|systemic: pathology microscopic-liver-pigmentation|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: clinical chemistry-albumin-albumin|systemic: pathology gross-sperm measure-sperm count|systemic: pathology microscopic-bone marrow-hyperplasia|systemic: hematology-anemia-anemia - macrocytic|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-liver-cytoplasmic alteration|systemic: clinical chemistry-protein-protein|systemic: in life observation-water consumption-water consumption|systemic: in life observation-clinical signs-defecation (diarrhea)|systemic: pathology microscopic-liver-degeneration|systemic: pathology microscopic-bone marrow-cellular alteration|systemic: pathology microscopic-spleen-pigmentation|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: pathology microscopic-blood-thrombocytopenia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15708481_15708482_15708483:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bd2c13237fc4e10000fb28f0a4e81b0e
ToxValDB ToxRefDB NOAEL =151 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; TITLE=Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_13 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5090; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: pathology gross-uterus-reduced size|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: clinical chemistry-creatine phosphokinase-creatine phosphokinase|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-anemia-anemia - macrocytic|systemic: organ weight-thymus-absolute|systemic: in life observation-clinical signs-defecation (diarrhea)|systemic: clinical chemistry-creatinine-creatinine|systemic: clinical chemistry-protein-protein|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: pathology microscopic-bone marrow-hypercellularity|systemic: in life observation-body weight-body weight gain|systemic: clinical chemistry-albumin-albumin|systemic: in life observation-body weight-body weight|systemic: hematology-platelet-platelet|systemic: hematology-reticulocyte-reticulocyte|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: pathology microscopic-liver-pigmentation|systemic: urinalysis-volume-volume|systemic: urinalysis-specific gravity/osmolality-specific gravity/osmolality|systemic: pathology microscopic-liver-cytoplasmic alteration|systemic: pathology microscopic-liver-degeneration|systemic: pathology microscopic-spleen-pigmentation|systemic: pathology microscopic-bone marrow-hyperplasia|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708478_15708479_15708480:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a8996e4a609495bf4a2e73ce60b7da98
ToxValDB ToxRefDB NOAEL =400 mg/kg bw/day Rat oral short-term; 14 days short-term LONG_REF=NTP_1993_Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Rats; TITLE=Technical report on the toxicity studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS No. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water_2 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5088; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15708466_15708467_15708468_15708469:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f5c2614a1c7eeb2ebacd0f8c66d5c36b
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier I0P9XEZ9WV UNII - - - chemical -