Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Butoxyethanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 222 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1180 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 150 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 12500 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Hemolytic activity demonstrated in animal studies; significant dermal penetration drives systemic exposure; CIR re-review pending due to >15 years since last assessment
Regulatory Flags
Frequently Asked Questions
Is Butoxyethanol safe in cosmetics?
Hemolytic activity demonstrated in animal studies; significant dermal penetration drives systemic exposure; CIR re-review pending due to >15 years since last assessment The EU classifies Butoxyethanol as "restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Butoxyethanol allowed in the EU?
Butoxyethanol EU regulatory status: restricted. Maximum allowed concentration: 4.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does Butoxyethanol do in cosmetics?
Butoxyethanol functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 111-76-2.
What is the Margin of Safety for Butoxyethanol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Butoxyethanol?
The NOAEL (No Observed Adverse Effect Level) for Butoxyethanol is 1000 mg/kg bw/day based on a Short Term Toxicity study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is Butoxyethanol classified as hazardous under GHS?
Butoxyethanol carries a GHS signal word of "DANGER". Hazard statements: Flammable liquid and vapour Fatal in contact with skin Harmful if swallowed May cause damage to organs. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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