NOAEL Studies
Cosmetic Ingredient
Butyl Acrylate NOAEL Studies
INCI: BUTYL ACRYLATE
CAS: 141-32-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"39, Sup 7, 71"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"39, Sup 7, 71"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"39, Sup 7, 71"} |
NTP_ICE_acute_inhalation 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 13.3 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3457; Record_ID=acute_inhalation_1587; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=13.3; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15779/7/3/3/?documentUUID=64514db3-f870-47aa-aad7-db9558b806a1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_acute_inhalation | LC50 | 33.3 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3458; Record_ID=acute_inhalation_1590; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=33.3; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15779/7/3/3/?documentUUID=331ed606-3006-4805-9ebc-ad4c022f2659; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_acute_inhalation | LC50 | <26.7 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3459; Record_ID=acute_inhalation_1592; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=<; Response=26.7; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15779/7/3/3/?documentUUID=331ed606-3006-4805-9ebc-ad4c022f2659; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_acute_inhalation | LC50 | 14.3 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3460; Record_ID=acute_inhalation_1593; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=14.3; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15779/7/3/3/?documentUUID=780b9b73-45f4-430a-9fce-b8f3faa0813f; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_acute_inhalation | LC50 | >5.24 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3461; Record_ID=acute_inhalation_1596; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.24; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15779/7/3/3/?documentUUID=65d4c185-2e30-414f-954f-8221056c4334; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_acute_inhalation | LC50 | 12.652 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3462; Record_ID=acute_inhalation_2338; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=12.652; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_acute_inhalation | LC50 | 14.0665 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3463; Record_ID=acute_inhalation_2339; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=14.0665; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_acute_inhalation | LC50 | 10.0063 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3464; Record_ID=acute_inhalation_2343; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=10.0063; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_acute_inhalation | LC50 | 14.3022 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3465; Record_ID=acute_inhalation_2614; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=14.3022; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_acute_inhalation | LC50 | 11.2113 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3466; Record_ID=acute_inhalation_2341; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.2113; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_acute_inhalation | LC50 | 10.3 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3467; Record_ID=acute_inhalation_1572; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=10.3; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15779/7/3/3/?documentUUID=7656cd7b-7ebf-48ed-a388-b92e5a736b7e; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_acute_inhalation | LC50 | 11.2 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3468; Record_ID=acute_inhalation_1578; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.2; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15779/7/3/3/?documentUUID=7656cd7b-7ebf-48ed-a388-b92e5a736b7e; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_acute_inhalation | LC50 | >23.04 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3469; Record_ID=acute_inhalation_1583; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=23.04; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15779/7/3/3/?documentUUID=76c902b8-695f-4d80-b681-22c00edc8eee; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_acute_inhalation | LC50 | 10 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3470; Record_ID=acute_inhalation_1586; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=10; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15779/7/3/3/?documentUUID=7656cd7b-7ebf-48ed-a388-b92e5a736b7e; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
NTP_ICE_acute_oral 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =900 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_3238; row=10343; data_type=In Vivo; mixture=Chemical; chemical_name=Butyl acrylate; preferred_name=Butyl acrylate; dtxsid=DTXSID6024676; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6024676; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =3143 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_3239; row=10344; data_type=In Vivo; mixture=Chemical; chemical_name=Butyl acrylate; preferred_name=Butyl acrylate; dtxsid=DTXSID6024676; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6024676; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =3730 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_3240; row=10345; data_type=In Vivo; mixture=Chemical; chemical_name=Butyl acrylate; preferred_name=Butyl acrylate; dtxsid=DTXSID6024676; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6024676; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =9050 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_3241; row=10346; data_type=In Vivo; mixture=Chemical; chemical_name=Butyl acrylate; preferred_name=Butyl acrylate; dtxsid=DTXSID6024676; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6024676; source_file=acute_oral.xlsx |
NTP_ICE_cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=6981; Record_ID=cancer_6889; Data_Type=WOE; Formulation_Name=Butyl acrylate; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/57; http://publications.iarc.fr/139; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5862; RecordID=ARPathway2016_836; DatasetName=ARPathway2016; DTXSID=DTXSID6024676; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
NTP_ICE_skin_sensitization 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD54, EC200 | 227 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3823; Record_ID=skin_sensitization_invitro_868; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=227; Reported_Response_Unit=ug/mL; Response=227; Response_Unit=ug/mL; Reference=Takenouchi submission to ICCVAM 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 184 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3822; Record_ID=skin_sensitization_invitro_868; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=184; Reported_Response_Unit=ug/mL; Response=184; Response_Unit=ug/mL; Reference=Takenouchi submission to ICCVAM 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 32 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8228; Record_ID=skin_sensitization_invitro_2251; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=249.6684091; Reported_Response_Unit=uM; Conversion_Factor_Value=128.171; Conversion_Factor_Source=EPA Dashboard; Converted_Response=32; Converted_Response_Unit=ug/mL; Response=32; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_skin_sensitization | CV75 | 332 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3824; Record_ID=skin_sensitization_invitro_868; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=h-CLAT; Endpoint=CV75; Reported_Response=332; Reported_Response_Unit=ug/mL; Response=332; Response_Unit=ug/mL; Reference=Takenouchi submission to ICCVAM 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_skin_sensitization | Depletion Cys | 100 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=207; Record_ID=skin_sensitization_invitro_82; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=100; Reported_Response_Unit=%; Response=100; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_skin_sensitization | Depletion Lys | 91.7 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=247; Record_ID=skin_sensitization_invitro_82; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=91.7; Reported_Response_Unit=%; Response=91.7; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_skin_sensitization | Depletion Lys | 85.1 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=366; Record_ID=skin_sensitization_invitro_95; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=85.1; Reported_Response_Unit=%; Response=85.1; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 92.55 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=287; Record_ID=skin_sensitization_invitro_95; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=92.55; Reported_Response_Unit=%; Response=92.55; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_skin_sensitization | EC1.5 | 37.74 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5125; Record_ID=skin_sensitization_invitro_1188; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=37.74; Reported_Response_Unit=uM; Response=37.74; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_skin_sensitization | EC1.5 | range13.27 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7591; Record_ID=skin_sensitization_invitro_1849; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=range; Reported_Response=13.27 to 26.53; Reported_Response_Unit=uM; Response=13.27 - 26.53; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_skin_sensitization | EC3 | 20 | % | Mouse | Dermal | - | In Vivo; Urbisch_SkinSensitization2020; LLNA | sheet=Data_invivo; excel_row=12927; Record_ID=skin_sensitization_invivo_2858; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=LLNA; Endpoint=EC3; Response=20; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_skin_sensitization | EC3 | 24.4 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13050; Record_ID=skin_sensitization_invivo_3022; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=LLNA; Endpoint=EC3; Response=24.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=NTP personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_skin_sensitization | EC3 | 11 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13052; Record_ID=skin_sensitization_invivo_3025; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=LLNA; Endpoint=EC3; Response=11; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_skin_sensitization | IC50 | 200.9 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5127; Record_ID=skin_sensitization_invitro_1188; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=200.9; Reported_Response_Unit=uM; Response=200.9; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
| NTP_ICE_skin_sensitization | Imax | 6.9 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5129; Record_ID=skin_sensitization_invitro_1188; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024676; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=6.9; Reported_Response_Unit=Unitless; Response=6.9; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024676; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024676 |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =89117.3 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=DOE Protective Action Criteria:15513031:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d241873be762324c350a9f583b296340 |
ToxValDB_ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | NOEL | =0.2 | mg/org | Mouse | dermal | chronic; 665 days | chronic | LONG_REF=J. Toxicol. Environ. Health14:115-120 DePass,L.R., E.H. Fowler, D.R. Meckley, and C.S. Weil Dermal Oncogenicity Bioassays of Acrylic Acid, Ethyl Acrylate, and Butyl Acrylate 1984; TITLE=Dermal Oncogenicity Bioassays of Acrylic Acid, Ethyl Acrylate, and Butyl Acrylate; AUTHOR=DePass,L.R., E.H. Fowler, D.R. Meckley, and C.S. Weil; DOI=10.1080/15287398409530566; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=91232; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15600513:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7bcb4d3bc24136d1a0f60d001457474a |
ToxValDB_EU_SCOEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EU_SCOEL | LOAEL | =78.6329 | mg/m3 | Rat | inhalation | chronic; 2 years | chronic | LONG_REF=Reininghaus, W., Koestner, A. and Klimisch, H.-J. (1991). Chronic toxicity, oncogenicity of inhaled methyl acrylate and n- butylacrylate in Sprague-Dawley rats. Food Chem. Toxicol. 29 , 329-339.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985c4e4b02565fc7d396b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/038_butyl_acrylate_oel_en.pdf; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=atrophy of the olfactory epithelium; STUDY_GROUP=EU SCOEL:15952339:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5e1d4cb8d551256a57099225a5b72231 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =11 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630392:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_26f4d1788005c462a27aa47cb4cc874e |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 705NM8U35V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"705NM8U35V"} |
| openFDA substances | FDA UNII substance identifier | 705NM8U35V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"705NM8U35V"} |
| openFDA substances | FDA UNII substance identifier | 705NM8U35V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"705NM8U35V"} |
| openFDA substances | FDA UNII substance identifier | 705NM8U35V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"705NM8U35V"} |