Is Butyl Acrylate safe in cosmetics?
Butyl Acrylate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Butyl Acrylate
Also known as: n-Butyl acrylate, 2-Propenoic acid, butyl ester, ACRYLATE, BUTYL, ACRYLIC ACID, BUTYL ESTER, PROP-2-ENOATE, BUTYL (+13 more)
INCI: BUTYL ACRYLATE
Butyl Acrylate (CAS 141-32-2) is a cosmetic cosmetic ingredient functioning as Film forming agent (used exclusively as polymerized monomer in acrylate. NOAEL 84 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 141-32-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Butyl Acrylate is classified GHS Danger (H226, H315, H317, H319, H332, H335, H412, H331) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Film forming agent (used exclusively as polymerized monomer in acrylate copolymers; unreacted monomer is not appropriate for cosmetic use)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
butyl prop-2-enoate
InChIKey
CQEYYJKEWSMYFG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Requires residual monomer quantification; MoS must be calculated based on residual free monomer in final product
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butyl Acrylate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation and through the skin.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Butyl Acrylate across SCCS product categories, with measured dermal absorption where available.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
39, Sup 7, 71
Evaluation Year
1998
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 3; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1
Hazard Statements
- H226 Flammable liquid and vapour
- H335 May cause respiratory irritation
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H317 May cause an allergic skin reaction
Inserted via ATP: CLP00
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
100%
DPRA Lys %
88.4%
KeratinoSens IC50
200.9 µM
hCLAT CV75
332 µg/mL
LLNA EC3
11.2%
NESIL
2800 µg/cm²
LLNA: Weak (1B)
GHS: 1B
Source: LLNA: Dearman et al. (2007); DPRA: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008] | Natsch et al. 2013 [DOI:10.1002/jat.2868]; KS: Joint Research Centre of the European Union 2014; hCLAT: Takenouchi submission to ICCVAM 2013
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
n-Butyl acrylate | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 39: (1986) Some Chemicals Used in Plastics and Elastomers | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Par
Source: International Agency for Research on Cancer (IARC)
Evidence for Carcinogenicity
Evaluation: No epidemiological data relevant to the carcinogenicity of n-butyl acrylate were available. There is inadequate evidence in experimental animals for the carcinogenicity of n-butyl acrylate. Overall Evaluation: n-Butyl acrylate is not classifiable as to its carcinogenicity to humans (Group 3). | A4; Not classifiable as a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
0400
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
The lower-mol-wt esters of acrylic acids are irritants to skin, eyes, and mucous membranes. /Acrylic acid esters/ | A skin and eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Butyl Acrylate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Butyl Acrylate by CAS number or substance name.
Studies
21
Lowest NOAEL
84 mg/kg bw/day
Highest NOAEL
2000 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
n-Butyl acrylate
2-Propenoic acid, butyl ester
ACRYLATE, BUTYL
ACRYLIC ACID, BUTYL ESTER
PROP-2-ENOATE, BUTYL
UN 2348 (DOT)
Butan-1-yl acrylate
Butyl propenoate
4-02-00-01463
BRN 1749970
EINECS 205-480-7
Butylester kyseliny akrylove
UNII-705NM8U35V
n-Butyl propenoate
YDCN 330-607P
DL 325
EM 24
BA 100PPM
Chemical Function
Binder
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Indirect additives food contact (10/2018)
Europe; nondetect; Other direct contact consumer goods
Europe; nondetect; Other direct contact consumer goods
drinking_water; Europe; manufacturing; plastic_additive
Cons electronics mech appliances and machinery; detected; Europe
Cons electronics mech appliances and machinery; detected; Europe
Cons electronics mech appliances and machinery; detected; Europe
Europe; nondetect; Other direct contact consumer goods
Europe; nondetect; Other direct contact consumer goods
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1546388
Frequently Asked Questions
Is Butyl Acrylate allowed in the EU?
Butyl Acrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Butyl Acrylate do in cosmetics?
Butyl Acrylate functions as: Film forming agent (used exclusively as polymerized monomer in acrylate copolymers; unreacted monomer is not appropriate for cosmetic use). It is classified as a cosmetic ingredient in our database. CAS number: 141-32-2.
Is Butyl Acrylate used outside cosmetics?
Butyl Acrylate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Butyl Acrylate have different safety status in cosmetics vs industrial chemicals?
Butyl Acrylate is classified GHS Danger (H226, H315, H317, H319, H332, H335, H412, H331) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Butyl Acrylate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acrylates/Vinyl Neodecanoate Crosspolymer
Excellent
Same category
Emulsion stabilising, film forming
Adipic Acid
Excellent
Same category
Buffering
Aluminum Magnesium Oxide
Excellent
Same category
Absorbent, bulking agent, opacifying ...
Ammonium VA/Acrylates Copolymer
Excellent
Same category
Antistatic, binding, film forming, ha...
Ammonium VA/Crotonic Acid Copolymer
Excellent
Same category
Antistatic, film forming, hair fixing...
Aphanothece Sacrum Polysaccharide
Excellent
Same category
Absorbent, emulsion stabilising, film...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
2,6-DIAMINOPYRIDINE
Good
Chemical family
Hair Dyeing
2,6-Diaminopyridine ⚠️
Poor
Chemical family
Hair dyeing (oxidative hair dye precu...
4-METHYLPENT-3-EN-2-ONE
Good
Chemical family
Perfuming
Is Butyl Acrylate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Butyl Acrylate in your formulation.