NOAEL Studies Cosmetic Ingredient

Butyl Ethyl Propanediol NOAEL Studies

INCI: BUTYL ETHYL PROPANEDIOL

CAS: 115-84-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 15 mg/kg bw/day rat oral 28 day Short Term Toxicity FCN; Twenty-eight Day Oral Toxicity Study in the Rat
ECHA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =15 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaceee4b0a7c65d1c1913; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12725/7/6/2?documentUUID=d0258aeb-9133-4e2d-8e1f-4a249604a161; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15843433:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_efbbeb8f74720cfd1811afbb20c866a8
ECHA NOAEL =150 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaceee4b0a7c65d1c1913; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12725/7/6/2?documentUUID=d0258aeb-9133-4e2d-8e1f-4a249604a161; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15843434:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3c27d9b221630e6ae0a45bf72c6ce4ff
ECHA NOAEL =1000 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaceee4b0a7c65d1c1917; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12725/7/6/2?documentUUID=d0258aeb-9133-4e2d-8e1f-4a249604a161; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843913_15843914:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f912e6117ee919e94f76c03414f75b41
ECHA NOEL =15 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaceee4b0a7c65d1c1917; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12725/7/6/2?documentUUID=d0258aeb-9133-4e2d-8e1f-4a249604a161; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843913_15843914:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca9c0cfaf52278f2390d43735a03dc01
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =5.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630433:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dcbf56f8c761797fe773bfa60aa9bfa9
ToxValDB HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HESS NOAEL =20 mg/kg bw/day Rat oral - subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0dd1e4b0a676289dd8ec; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Clinical Observation: Staggering gait|Water Consumption: increase|Urinalysis: pH decrease|Hematology: LYMPH increase, NEUT decrease|Absolute Organ Weight: Kidney increase|Relative Organ Weight: Liver increase, Kidney increase|Necropsy: Stomach-Thickening, limiting ridge|Histopathology: Kidney-Cast, granular Kidney-Regeneration, tubular Kidney-Eosinophilic body, tubular cell Kidney-Necrosis/Desquamation, tubular cell Stomach-Hyperplasia, squamous, limiting ridge; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|food and/or water consumption|gross pathology|hematology|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=HESS:15638836:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_357ed4ffba2c7521b2ec5045768f3886
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 61P3KJ8K4Y UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"61P3KJ8K4Y"}
openFDA substances FDA UNII substance identifier 61P3KJ8K4Y UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"61P3KJ8K4Y"}
openFDA substances FDA UNII substance identifier 61P3KJ8K4Y UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"61P3KJ8K4Y"}
openFDA substances FDA UNII substance identifier 61P3KJ8K4Y UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"61P3KJ8K4Y"}