Is Butyl Ethyl Propanediol safe in cosmetics?
Butyl Ethyl Propanediol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Butyl Ethyl Propanediol
Also known as: 1,3-Propanediol, 2-butyl-2-ethyl-, 4-01-00-02611, 3,3-Bis(hydroxymethyl)heptane, BRN 1737392, Caswell No. 129 (+6 more)
INCI: BUTYL ETHYL PROPANEDIOL
Butyl Ethyl Propanediol (CAS 115-84-4) is a cosmetic cosmetic ingredient functioning as Humectant, skin conditioning. NOAEL 15 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 115-84-4 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant, skin conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-butyl-2-ethylpropane-1,3-diol
InChIKey
DSKYSDCYIODJPC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Adequate — supported by alkane diols class assessment
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butyl Ethyl Propanediol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Butyl Ethyl Propanediol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =15 mg/kg bw/day | oral | Rat | subchronic | ECHA |
| NOAEL | =150 mg/kg bw/day | oral | Rat | subchronic | ECHA |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | short-term | ECHA |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Butyl Ethyl Propanediol across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Butyl Ethyl Propanediol.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Butyl Ethyl Propanediol by CAS number or substance name.
Studies
3
Lowest NOAEL
15 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA
Known Synonyms
1,3-Propanediol, 2-butyl-2-ethyl-
4-01-00-02611
3,3-Bis(hydroxymethyl)heptane
BRN 1737392
Caswell No. 129
EINECS 204-111-7
EPA Pesticide Chemical Code 041003
2-Ethyl-2-butyl-1,3-propandeiol
2-Ethyl-2-butyl-1,3-propanediol
NSC 406603
UNII-61P3KJ8K4Y
Chemical Function
Humectant
Softener and conditioner
Regulatory Lists
detected; Europe; Toys and children's products
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3185639
Frequently Asked Questions
Is Butyl Ethyl Propanediol allowed in the EU?
Butyl Ethyl Propanediol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Butyl Ethyl Propanediol do in cosmetics?
Butyl Ethyl Propanediol functions as: Humectant, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 115-84-4.
What is the NOAEL for Butyl Ethyl Propanediol?
The NOAEL (No Observed Adverse Effect Level) for Butyl Ethyl Propanediol is =15 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 3 study endpoints are available. Source: ECHA.
Is Butyl Ethyl Propanediol used outside cosmetics?
Butyl Ethyl Propanediol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Butyl Ethyl Propanediol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Good
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Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
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(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
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Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
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(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
2-Methyl-3-Buten-2-Ol
Good
Chemical family
Flavouring and nutrient; Fragrance
AMINOETHYL PROPANEDIOL
Good
Chemical family
Buffering
Alpha-Santalol
Moderate
Chemical family
Fragrance
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