NOAEL Studies Cosmetic Ingredient

Butyl Methacrylate NOAEL Studies

INCI: BUTYL METHACRYLATE

CAS: 97-88-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 2B IARC group - - 2023 IARC Monographs -
NTP ICE acute inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 28.5382 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2405; Record_ID=acute_inhalation_1050; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID4024696; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=28.5382; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4024696
NTP ICE acute oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_11858; row=7263; data_type=In Vivo; mixture=Chemical; chemical_name=Butyl methacrylate; preferred_name=Butyl methacrylate; dtxsid=DTXSID4024696; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4024696; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =16000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11859; row=7262; data_type=In Vivo; mixture=Chemical; chemical_name=Butyl methacrylate; preferred_name=Butyl methacrylate; dtxsid=DTXSID4024696; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4024696; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =22600 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11860; row=7261; data_type=In Vivo; mixture=Chemical; chemical_name=Butyl methacrylate; preferred_name=Butyl methacrylate; dtxsid=DTXSID4024696; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4024696; source_file=acute_oral.xlsx
NTP ICE skin irritation 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin irritation Positive reaction 0 % Human Dermal - In Vivo; Four-hour Human Patch Test sheet=Data_invivo; excel_row=862; Record_ID=skin_irritation_invivo_40; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID4024696; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=0; Response_Unit=%; Species=Human; Reference=Jirova et al. 2010; 20136894; 10.1111/j.1600-0536.2009.01640.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4024696
NTP ICE skin irritation Viability 10.65 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=3097; Record_ID=skin_irritation_invitro_1349; Data_Type=In Vitro; Formulation_Name=Butyl methacrylate; Mixture=Chemical; DTXSID=DTXSID4024696; Assay=EpiSkin Irritation; Endpoint=Viability; Response=10.65; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4024696
NTP ICE skin irritation Viability 11.25 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=3098; Record_ID=skin_irritation_invitro_1350; Data_Type=In Vitro; Formulation_Name=Butyl methacrylate; Mixture=Chemical; DTXSID=DTXSID4024696; Assay=EpiSkin Irritation; Endpoint=Viability; Response=11.25; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4024696
NTP ICE skin irritation Viability 22.5 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=3099; Record_ID=skin_irritation_invitro_1351; Data_Type=In Vitro; Formulation_Name=butyl methacrylate; Mixture=Chemical; DTXSID=DTXSID4024696; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=22.5; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4024696
NTP ICE skin irritation Viability 25.6 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=3100; Record_ID=skin_irritation_invitro_1352; Data_Type=In Vitro; Formulation_Name=butyl methacrylate; Mixture=Chemical; DTXSID=DTXSID4024696; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=25.6; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4024696
NTP ICE skin irritation Viability 28.7 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=3101; Record_ID=skin_irritation_invitro_1353; Data_Type=In Vitro; Formulation_Name=butyl methacrylate; Mixture=Chemical; DTXSID=DTXSID4024696; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=28.7; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4024696
NTP ICE skin irritation Viability 39.2 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=3079; Record_ID=skin_irritation_invitro_1354; Data_Type=In Vitro; Formulation_Name=butyl methacrylate; Mixture=Chemical; DTXSID=DTXSID4024696; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=39.20; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4024696
NTP ICE skin irritation Viability 39.8 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=3080; Record_ID=skin_irritation_invitro_1355; Data_Type=In Vitro; Formulation_Name=butyl methacrylate; Mixture=Chemical; DTXSID=DTXSID4024696; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=39.80; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4024696
NTP ICE skin irritation Viability 59.5 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=3081; Record_ID=skin_irritation_invitro_1356; Data_Type=In Vitro; Formulation_Name=butyl methacrylate; Mixture=Chemical; DTXSID=DTXSID4024696; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=59.5; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4024696
NTP ICE skin irritation Viability 66.3 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=3082; Record_ID=skin_irritation_invitro_1357; Data_Type=In Vitro; Formulation_Name=butyl methacrylate; Mixture=Chemical; DTXSID=DTXSID4024696; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=66.3; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4024696
NTP ICE skin irritation Viability 92.64 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=3102; Record_ID=skin_irritation_invitro_1358; Data_Type=In Vitro; Formulation_Name=Butyl methacrylate; Mixture=Chemical; DTXSID=DTXSID4024696; Assay=EpiDerm Irritation; Endpoint=Viability; Response=92.64; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4024696
NTP ICE skin irritation Viability 98.11 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=3083; Record_ID=skin_irritation_invitro_1359; Data_Type=In Vitro; Formulation_Name=Butyl methacrylate; Mixture=Chemical; DTXSID=DTXSID4024696; Assay=EpiDerm Irritation; Endpoint=Viability; Response=98.11; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024696; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4024696
ECHA 16 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL >=1163.18 mg/m3 Rat inhalation - acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/3/3?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15798401:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_76ebb37e4b06d450ad05a403be2252fc
ECHA LEL =6000 mg/m3 Rat inhalation - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/3/3?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15796840_15798631_15798892_15799030:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_32e8c3713c2b779198ee0f5c023124d1
ECHA LEL =19700 mg/m3 Rat inhalation - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/3/3?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15796840_15798631_15798892_15799030:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_94d7d5ef72b287ab5638f7942c1e7bcf
ECHA LEL =29000 mg/m3 Rat inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/3/3?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15797243:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_948562bac22feb4f369a312327af63fc
ECHA LOAEC =5536.73 mg/m3 Rat inhalation short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/6/3?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829107_15829108_15829109:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b347ba0d13eac2e49b45e839af47645b
ECHA NOAEC =581.59 mg/m3 Rat inhalation - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d24be4b0a7c65d2327bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/9/3?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15822965:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_445f1a5792a30164c6250ad2f79ee502
ECHA NOAEC =1744.77 mg/m3 Rat inhalation - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d24be4b0a7c65d2327bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/9/3?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821676:F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8fcbeb13bf28f3baf64c088eae63255e
ECHA NOAEC =1802.93 mg/m3 Rat inhalation short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/6/3?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829107_15829108_15829109:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_54ff01a344aee7c4a38228fd20c5bef6
ECHA NOAEC =10997.9 mg/m3 Rat inhalation short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/6/3?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829107_15829108_15829109:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a2e8a4708da476048da7834dba127a38
ECHA NOAEL =30 mg/kg bw/day Rat oral subchronic; 44 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8ee4b0a7c65d1ce6f8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/6/2?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15850051:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_70b79926338340cc134bea9a7693a481
ECHA NOAEL =100 mg/kg bw/day Rabbit oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac93e4b0a7c65d1bfdfe; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/9/3?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15825334:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3e3079cf2c01e380552107d47b5bdf94
ECHA NOAEL =120 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8ee4b0a7c65d1ce6ef; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/6/2?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15850050:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_298fb08a988b9bb42785e51f41824baa
ECHA NOAEL =300 mg/kg bw/day Rabbit oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac93e4b0a7c65d1bfdfe; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/9/3?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15825335:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a7fbcc2838f0585dc7285d3ab7e5625c
ECHA NOAEL =360 mg/kg bw/day Rat oral - repeat dose other QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4f52; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/10/1?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15826078:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_137ebe8501775a5f241f3ece8223ae37
ECHA NOAEL =1000 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac93e4b0a7c65d1bfe08; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/9/3?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15825336:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9f20683fddc13c047357bc661cc45e7f
ECHA NOAEL =3501.17 mg/m3 Rat inhalation chronic; 4 months chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/6/3?documentUUID=e793b5c4-5ec8-47c1-b1bb-d57133e97e98; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15829278:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9d3c1fdcdf0971368fead3f3866cad82
ToxValDB GESTIS DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =409 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630445_15630446:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6983b10843b1b195444aa0b43cfe6fa1
ToxValDB GESTIS DNEL DNEL systemic =415.9 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630445_15630446:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e021c9894d817db190d621b6ba3f9d2
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier R5QX287XXU UNII - - - chemical -