NOAEL Studies Antioxidant

Butylated Hydroxytoluene NOAEL Studies

INCI: BHT

CAS: 128-37-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 36 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 800 mg/kg bw/day mouse oral 7-13 Gestation day Developmental PAFA; ASP
COSMOS DB NOAEL 3.2 mg/kg bw/day rabbit oral 13 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 4 mg/kg bw/day dog oral 365 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 6 mg/kg bw/day rat oral 365 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 12.5 mg/kg bw/day rat oral 175 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 25 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 34 mg/kg bw/day chinese hamster oral 14 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 50 mg/kg bw/day rat oral 730 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 58 mg/kg bw/day mouse oral 14 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 75 mg/kg bw/day mouse oral 305 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 85 mg/kg bw/day guinea pig oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 100 mg/kg bw/day rat oral 49 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 150 mg/kg bw/day mouse oral 700 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 160 mg/kg bw/day rat oral 730 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 180 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 200 mg/kg bw/day rat oral 560 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 225 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 240 mg/kg bw/day mouse oral 7 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 250 mg/kg bw/day rat oral 224 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 280 mg/kg bw/day hamster oral 5 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 300 mg/kg bw/day rat oral 175 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 330 mg/kg bw/day rat oral 224 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 400 mg/kg bw/day mouse oral 1 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 408 mg/kg bw/day guinea pig oral 17 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 450 mg/kg bw/day mouse oral 756 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 465 mg/kg bw/day mouse oral 49 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 500 mg/kg bw/day rat oral 730 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 600 mg/kg bw/day mouse oral 672 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 608 mg/kg bw/day mouse oral NA Multigeneration Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 620 mg/kg bw/day rat oral 49 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 660 mg/kg bw/day rat oral 161 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 698 mg/kg bw/day rat oral 28 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 700 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 750 mg/kg bw/day mouse oral 1036 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 790 mg/kg bw/day dog oral 365 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 918 mg/kg bw/day rat oral 7 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =25 mg/kg bw/day Rat oral: feed - reproduction toxicity EFSA ANS - 2012 - OutputID 490 - development - developmental - Scientific Opinion on the re-evaluation of butylated hydroxytoluene BHT (E 321) as a food additive - doi:10.2903/j.efsa.2012.2588
EFSA ADI =0.25 mg/kg bw/day Consumers - - ADI EFSA ANS - 2012 - OutputID 490 - Consumers - Scientific Opinion on the re-evaluation of butylated hydroxytoluene BHT (E 321) as a food additive - doi:10.2903/j.efsa.2012.2588
EFSA NOAEL =25 mg/kg bw/day Rat oral - developmental LONG_REF=EFSA ANS (2012). Scientific Opinion on the re-evaluation of butylated hydroxytoluene BHT (E 321) as a food additive. doi:10.2903/j.efsa.2012.2588.; TITLE=Scientific Opinion on the re-evaluation of butylated hydroxytoluene BHT (E 321) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2012.2588; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=development; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=EFSA:15614340:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0144a6ce3f3b00a57f7c5a829ddb999c
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs -
NTP ICE acute oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =890 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2094; row=3749; data_type=In Vivo; mixture=Chemical; chemical_name=Butylated hydroxytoluene; preferred_name=Butylated hydroxytoluene; dtxsid=DTXSID2020216; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020216; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2020216; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 >6000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_2096; row=3750; data_type=In Vivo; mixture=Chemical; chemical_name=Butylated hydroxytoluene; preferred_name=Butylated hydroxytoluene; dtxsid=DTXSID2020216; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020216; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2020216; source_file=acute_oral.xlsx
NTP ICE cancer 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=2277; Record_ID=cancer_6431; Data_Type=WOE; Formulation_Name=Butylated hydroxytoluene; Mixture=Chemical; DTXSID=DTXSID2020216; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/58; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020216; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020216
NTP ICE cancer Top dose 6000 ppm Rat - - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=2269; Record_ID=cancer_6432; Data_Type=In Vivo; Formulation_Name=Butylated hydroxytoluene; Mixture=Chemical; DTXSID=DTXSID2020216; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=6000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Reference=TR-150; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr150/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020216; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020216
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=5902; RecordID=ARPathway2016_761; DatasetName=ARPathway2016; DTXSID=DTXSID2020216; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020216; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020216
SCCS Opinion 30 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.5 % rat oral 90 days NOAEL study p.32
SCCS Opinion NOAEL =7 - - - - NOAEL study p.24
SCCS Opinion NOAEL =10 mg/kg bw/day rat - 24 wk NOAEL study Ref.: Modified from EDC dossier 2019, p.35
SCCS Opinion NOAEL =15 mg/kg bw/day - - - NOAEL study Ref.: Modified from EDC dossier 2019, p.35
SCCS Opinion NOAEL =15 - rat - 18 wk NOAEL study p.34
SCCS Opinion NOAEL =20 mg/kg/day rat - 8 wk NOAEL study p.33
SCCS Opinion NOAEL =25 mg/kg bw rat - Chronic reproductive toxicity p.17
SCCS Opinion NOAEL =25 mg/kg bw/day rat - - carcinogenicity p.25
SCCS Opinion NOAEL =25 - - - - NOAEL study p.24
SCCS Opinion NOAEL =28 - rat - 28 days NOAEL study p.35
SCCS Opinion NOAEL =30 - rat - 8 wk NOAEL study p.34
SCCS Opinion NOAEL =32 - - - - NOAEL study p.32
SCCS Opinion NOAEL =33 - - - - NOAEL study p.33
SCCS Opinion NOAEL =34 - - - - NOAEL study p.34
SCCS Opinion NOAEL =35 - - - - NOAEL study p.35
SCCS Opinion NOAEL =38 mg/kg bw/day rat - - carcinogenicity Ref.: EFSA 2012, p.19
SCCS Opinion NOAEL =50 - - - 4 wk NOAEL study p.33
SCCS Opinion NOAEL =67 - rat - - NOAEL study p.32
SCCS Opinion NOAEL =75 - rat - 76 wk NOAEL study p.35
SCCS Opinion NOAEL =100 - rat oral 22 weeks NOAEL study p.33
SCCS Opinion NOAEL =125 - rat - 104 wk NOAEL study p.34
SCCS Opinion NOAEL =200 - rat - 24 wk NOAEL study p.35
SCCS Opinion NOAEL =225 - rat - 105 wk NOAEL study p.34
SCCS Opinion NOAEL =247 mg/kg bw/day rat - - carcinogenicity Ref.: Brooks 1976, p.19
SCCS Opinion NOAEL =250 - - - - NOAEL study p.34
SCCS Opinion NOAEL =450 mg/kg bw/day rat - Chronic reproductive toxicity Ref.: EFSA 2012, p.17
SCCS Opinion NOAEL =500 - rat oral 14 wk NOAEL study p.33
SCCS Opinion NOAEL =515 - - - 107 wk NOAEL study p.34
SCCS Opinion NOAEL =1636 - rat oral 144 wk NOAEL study p.33
SCCS Opinion NOAEL =1640 - - - 104 wk NOAEL study p.34
ECHA 53 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL >=23 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbf69; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823212_15823213:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f3bb95b8169bcffc8589edebe7fa64a7
ECHA LEL =100 mg/kg bw/day Rat oral chronic; 14 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2ce3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839242_15839243_15839244:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0ba5cb63e1e2e154f72de49b0c9180c1
ECHA LEL =125 mg/kg bw/day Rat oral chronic; 104 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2cd1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836171_15836172:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8cc5b5ad30e23f32a84de95593eec04e
ECHA LEL =185 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2165fe; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817340_15819075:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_57dd9810fa29a267880f6d2a3d71a748
ECHA LEL =200 mg/kg bw/day Mouse injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61ccce4b096bca8773732; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/3/5?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15815633:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ac169636416b41379879986676b41e66
ECHA LEL =250 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818421_15818745_15819262:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c6bd4bc4b469efb7ee4af6c3daa3d980
ECHA LEL ~333 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b653c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857319_15857783:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a714264d32c1633a0bbf283312fbe4b2
ECHA LEL =500 mg/kg bw/day Rat oral chronic; 104 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2cd1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836171_15836172:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_13732e713ffd1458ac315b3bc7cd1403
ECHA LEL =538.05 mg/m3 Mouse inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/3/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15799127:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1c30238f73d43f4a98d6c0a1d77b046a
ECHA LEL <=608 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbf69; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823212_15823213:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2e8f36e341d14c87a3b4d9dccf6f65a1
ECHA LEL >=669 mg/kg bw/day Rat oral subchronic; 40 days subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d2217c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838212_15846931_15846932:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_89f82654065851e39533ddaa6b9abaf3
ECHA LEL <=864 mg/kg bw/day Rat oral subchronic; 40 days subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d2217c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838212_15846931_15846932:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_29cb12c26eb646665c4b76dfb6245dc2
ECHA LEL ~900 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30db; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817032_15817033_15817034:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4ec4bff2ee4d149b1bb082f65e40708b
ECHA LEL =925 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2165fe; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817341_15819073_15819074:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8dffa2a399b222ca14440350d1a6bb49
ECHA LEL >=940 mg/kg bw/day Cat oral - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/3/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15813947_15813948:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_82bf96c31b6e00b8d1645b558d944b74
ECHA LEL <=2100 mg/kg bw/day Cat oral - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/3/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15813947_15813948:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ab2d9b69d14394eeca3d18feb482c5ef
ECHA LEL =3000 ppm Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8afe4b0a7c65d219b52; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857764_15857840:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_571cf0f90f60b5f56bdb27299f9fcdc0
ECHA LEL <=3200 mg/kg bw/day Rabbit oral - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/3/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15814231_15814232:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_31d6e17bf4b42a6d96095e7deec5c999
ECHA LEL >=3480 mg/kg bw/day Mouse oral subchronic; 10 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2cef; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847149_15847150:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_38737647da1e5c51c1ddbd541e7ce52f
ECHA LEL <=4130 mg/kg bw/day Mouse oral subchronic; 10 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2cef; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847149_15847150:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_73e0dfbbda4767f0ddb4f19c09429c6c
ECHA LEL =10700 mg/kg bw/day Guinea Pig oral - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/3/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15804472:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8560478a155fa1656021f0a2b666fffa
ECHA LOAEL =15 mg/kg bw/day Rat oral short-term; 1 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d2217c2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834865_15834866:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_48590910ad932865d8b2c26379c9953c
ECHA LOAEL =100 mg/kg bw/day Rat oral short-term; 3 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d221812; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837763_15837764_15837765:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_096258fbb862dcaa9032c4195ed00b5c
ECHA LOAEL =160 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30e7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819203_15819204_15819205:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c2f287b3d730d69085595c5a21872abd
ECHA LOAEL =167 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbf6f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822124_15822786_15822868_15823121:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a5b40da71847064f9aecfa9f6e39862b
ECHA LOAEL =225 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819246_15819247_15819879_15819880_15819881_15819882:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ef3deb0ba0e5763df86c7bee9e8c7516
ECHA LOAEL =250 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be4e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/34499/7/9/3?documentUUID=c664dab6-36ff-4cc4-8d00-5af27c01d424; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: changes in litter size and weights; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15820919:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0b9d8c2541461882640346477335cc38
ECHA LOAEL =326 mg/kg bw/day Rat oral short-term; 1 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d2217c2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834865_15834866:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f399e980ea3322ed7becae5adb0fe155
ECHA LOAEL ~450 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30db; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817032_15817033_15817034:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ccb14b723c979f40c81be4dba74f71ae
ECHA LOAEL =500 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbf79; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821618:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a61f90ee852f512237ce2e957ddbf2b0
ECHA LOAEL =643 mg/kg bw/day Rat oral short-term; 3 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d221880; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=blood: haematology|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|mortality/survival; STUDY_GROUP=ECHA IUCLID:15845166:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6445ec1d097fa0aa9535ca852622e998
ECHA LOAEL =750 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be4ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/34499/7/9/3?documentUUID=c664dab6-36ff-4cc4-8d00-5af27c01d424; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=maternal: early or late resorptions|maternal: total litter losses by resorption; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15822516:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c00b667e74b37110a0bf43df57930267
ECHA LOAEL =1000 mg/kg bw/day Rat oral short-term; 7 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d2217b4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=liver: body weight and weight gain|haematology|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|mortality/survival|organ weight; STUDY_GROUP=ECHA IUCLID:15831095:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0fa36b77f1bbc161bd5d51d12dc2a38d
ECHA LOAEL ~3480 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d216600; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15819076:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8c3f461e1a9b4ff98c3d47bbb7b07331
ECHA LOEL =462.5 mg/kg bw/day Mouse oral chronic; 18 months chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2ced; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15841838:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1c8635fc672547335c4ac0904fabaec8
ECHA LOEL =500 mg/kg bw/day Rat oral acute; 1 days acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d221891; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15845816:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0a8e02a7064950c7de65b069216ca26d
ECHA NOAEL =10 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30e7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819203_15819204_15819205:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b65091e0820e9c95e384f5621e546bc9
ECHA NOAEL =23.4 mg/kg bw/day Rat oral chronic; 18 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2caf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15830440:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0e4ef6b35aa1b5a6f3b1845a8e62e5c0
ECHA NOAEL =25 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30dd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=liver: clinical biochemistry|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15817283:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_58cc9f0de4e1bce14c26039c6535f9eb
ECHA NOAEL =27.8 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2cf5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15846300:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_24bb0d5f15f0b640699f54d6f545cacd
ECHA NOAEL =50 mg/kg bw/day Monkey oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1a6e4b0a7c65d22f7cf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822398_15822799:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_114f2e063eb4e71d34999adea4d8b9a9
ECHA NOAEL >=61 mg/kg bw/day Pig oral subchronic; 42 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d221878; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15844980:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1967e043e200445686e8b93db79be32b
ECHA NOAEL ~70 mg/kg bw/day Rat oral short-term; 1 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d2217df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15837605:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a7bd396475fa4fe6df4fbeeab96e43fa
ECHA NOAEL =75 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819246_15819247_15819879_15819880_15819881_15819882:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_047848372848aa2c9165bfb0a5c4aa4f
ECHA NOAEL =100 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b653e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855410_15856228_15857465_15857899_15857912_15857930:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_be24d92faeb4548826d7e72b1fbe3dcc
ECHA NOAEL =180 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbf67; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822077_15822824:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6c069c37238be5920deb8d6c0635e2ec
ECHA NOAEL =225 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbf61; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821931_15822612:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6693b6d1d597155a72303c566a299526
ECHA NOAEL =280 mg/kg bw/day Hamster oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1a6e4b0a7c65d22f7cb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822134_15822289:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4aff9a1b1de7d4a81d60453f1df6f733
ECHA NOAEL =500 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1a6e4b0a7c65d22f7b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822124_15822786_15822868_15823121:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_93fe5d3629e5dc5cda6754d833e7e5b4
ECHA NOAEL =608 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b6538; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=F2: developmental neurotoxicity; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15860198:M/F:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c8d6baf77658fd234f254ee191658fbb
ECHA NOAEL =660 mg/kg bw/day Mouse oral short-term; 30 days short-term QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2ce5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15839620:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1733d00ae3fda40e561ac43697e14b3d
ECHA NOAEL =800 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbf65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820723_15821516:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_219dfd5f9e22b598198702a6ce53f9cf
ECHA NOEL =10 mg/kg bw/day Rat oral short-term; 3 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d221812; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15837762:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f39b7d691ff490703fac65b834ed8ecb
ToxValDB ECOTOX 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =1 % Rat oral subchronic; 56 days subchronic LONG_REF=Toxicol. Lett.55(3): 263-272 Shibata,M.A., E. Asakawa, A. Hagiwara, Y. Kurata, and S. Fukushima DNA Synthesis and Scanning Electron Microscopic Lesions in Renal Pelvic Epithelium of Rats Treated with Bladder Cancer Promoters 1991; TITLE=DNA Synthesis and Scanning Electron Microscopic Lesions in Renal Pelvic Epithelium of Rats Treated with Bladder Cancer Promoters; AUTHOR=Shibata,M.A., E. Asakawa, A. Hagiwara, Y. Kurata, and S. Fukushima; DOI=10.1016/0378-4274(91)90006-r; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107545; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594699_15594700:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2ca1b8b7e050a958d47ae76b15d17eb5
ToxValDB ECOTOX LOEL =100 mg/kg bw/day Mouse oral acute; 1 days acute LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603124_15603125:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2a06e71228789dc971eb8c4afd6d07bc
ToxValDB ECOTOX NOEL =10 mg/kg bw/day Mouse oral acute; 1 days acute LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603124_15603125:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c82c6e5b9f35fe860115fa0763315ca6
ToxValDB ECOTOX NOEL =900 mg/kg bw/day Rat oral short-term; 1.625 days short-term LONG_REF=Mutat. Res.320(3): 189-205 Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens 1994; TITLE=An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens; AUTHOR=Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa; DOI=10.1016/0165-1218(94)90046-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75058; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15599293:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9d4aa838b928802667ea70ef7074a504
ToxValDB ECOTOX NOEL =1000 mg/kg bw/day Mouse oral short-term; 2 days short-term LONG_REF=Mutat. Res.343(2/3): 157-183 Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens 1995; TITLE=The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens; AUTHOR=Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa; DOI=10.1016/0165-1218(95)90082-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=75052; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15600045:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8bdc4b118257ddb5ba1d4e8de3ab69e5
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =1.76 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631031:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0828a1c059bd09eec7cf03170b731d05
ToxValDB PPRTV (CPHEA) 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB PPRTV (CPHEA) RfD (provisional) =0.3 mg/kg bw/day Human oral - Toxicity Value LONG_REF=Olsen et al. 1986; AUTHOR=Olsen et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b379; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1615; TOXICOLOGICAL_EFFECT=Decreased F1 adult weight at 138 weeks in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653687_15653771:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2bff1d6d1c25603e1efde4d3ea29f288
ToxValDB PPRTV (CPHEA) RfD (provisional) =1 mg/kg bw/day Human oral - Toxicity Value LONG_REF=Olsen et al. 1986; AUTHOR=Olsen et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b379; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1615; TOXICOLOGICAL_EFFECT=Decreased F1 adult weight at 9 weeks in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653687_15653771:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2c2ba44f53b00fdbc281ceeab762debe
Regulatory source 44 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 0.5 % rat oral 90 days - p.32
Regulatory source - 7 - - - - - p.24
Regulatory source - 10 mg/kg bw/day rat - 24 wk - p.35
Regulatory source - 10 - rat - 104 wk - p.34
Regulatory source - 15 mg/kg bw/day - - - - p.35
Regulatory source - 15 - rat - 18 wk - p.34
Regulatory source - 20 mg/kg/day rat - 8 wk - p.33
Regulatory source - 25 mg/kg bw - oral - - p.24
Regulatory source - 25 - - - - - p.24
Regulatory source - 25 - - dermal - - p.24
Regulatory source - 25 - - oral - - p.24
Regulatory source - 25 - rat - 144 wk - p.32
Regulatory source - 25 - rat - - - p.32
Regulatory source - 25 - rat - 90 days - p.34
Regulatory source - 25 - rat - 28 days - p.34
Regulatory source - 28 - rat - 28 days - p.35
Regulatory source - 30 - rat - 8 wk - p.34
Regulatory source - 32 - - - - - p.32
Regulatory source - 33 - - - - - p.33
Regulatory source - 34 - - - - - p.34
Regulatory source - 35 - - - - - p.35
Regulatory source - 50 - - - 4 wk - p.33
Regulatory source - 67 - rat - - - p.32
Regulatory source - 75 - rat - 76 wk - p.35
Regulatory source - 100 - rat oral 22 weeks - p.33
Regulatory source - 100 - rat - 6 wk - p.33
Regulatory source - 100 - - - - - p.33
Regulatory source - 125 - rat - 104 wk - p.34
Regulatory source - 200 - rat - 24 wk - p.35
Regulatory source - 225 - rat - 105 wk - p.34
Regulatory source - 250 - - - - - p.34
Regulatory source - 500 - rat oral 14 wk - p.33
Regulatory source - 500 - - - - - p.33
Regulatory source - 515 - - - 107 wk - p.34
Regulatory source - 1636 - rat oral 144 wk - p.33
Regulatory source - 1636 - rat - 104 wk - p.34
Regulatory source - 1636 - rat oral 16 wk - p.35
Regulatory source - 1640 - - - 104 wk - p.34
Regulatory source carcinogenicity 25 mg/kg bw/day rat - - carcinogenicity p.25
Regulatory source carcinogenicity 38 mg/kg bw/day rat - - carcinogenicity p.19
Regulatory source carcinogenicity 247 mg/kg bw/day rat - - carcinogenicity p.19
Regulatory source reproductive toxicity 25 mg/kg bw rat - Chronic reproductive toxicity p.17
Regulatory source reproductive toxicity 25 mg/kg bw/day rat - - reproductive toxicity p.19
Regulatory source reproductive toxicity 450 mg/kg bw/day rat - Chronic reproductive toxicity p.17
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 1P9D0Z171K UNII - - - chemical -