NOAEL Studies Humectant

Butylene Glycol NOAEL Studies

INCI: BUTYLENE GLYCOL

CAS: 107-88-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =500 mg/kg rat oral - oral toxicity 3; 1; 8, p.12
CIR Safety Assessment NOAEL =0.5 - rat oral (dietary) 90 days NOAEL study p.12
CIR Safety Assessment NOAEL =0.6 - mouse oral (dietary) 90 days NOAEL study p.12
CIR Safety Assessment NOAEL =167 - pig oral 90 days NOAEL study p.12
COSMOS DB 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 750 mg/kg bw/day dog oral 730 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 5000 mg/kg bw/day rat oral 730 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 6000 mg/kg bw/day dog oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 7060 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 10000 mg/kg bw/day rat oral 450 day Multigeneration Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA ADI <=4 mg/kg bw/day Consumers - - ADI EFSA CONTAM - 2011 - OutputID 586 - Consumers - Scientific Opinion on the evaluation of the substances currently on the list in the Annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part I of III - doi:10.2903/j.efsa.2011.2482
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=660; RecordID=ARPathway2016_500; DatasetName=ARPathway2016; DTXSID=DTXSID8026773; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026773
WHO/JECFA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
WHO/JECFA ADI <=4 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af042e4b0d99f5a86d48e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/2551; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=WHO JECFA ADI:15715240:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9fd7181c5dabbfe3511d9e97dd9b1f8d
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 3XUS85K0RA UNII - - - chemical -