Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Butylene Glycol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 750 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 7060 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Reproductive-developmental | COSMOS_DB |
| NOAEL | 10000 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | dog | Developmental | COSMOS_DB |
| NOAEL | 6000 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 750 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Butylene Glycol, relevant to systemic exposure and MoS calculations.
Source: CIR
Expert Verdict
Preferred diol humectant for sensitive-skin formulations with lighter sensory profile and lower irritation potential compared to propylene glycol. Non-occlusive hygroscopic mechanism with excellent tolerability on sensitive and reactive skin.
Regulatory Flags
Frequently Asked Questions
Is Butylene Glycol safe in cosmetics?
Preferred diol humectant for sensitive-skin formulations with lighter sensory profile and lower irritation potential compared to propylene glycol. Non-occlusive hygroscopic mechanism with excellent tolerability on sensitive and reactive skin. The EU classifies Butylene Glycol as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Butylene Glycol allowed in the EU?
Butylene Glycol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Butylene Glycol do in cosmetics?
Butylene Glycol functions as: Diol humectant and solvent. Attracts water into the stratum corneum. Lighter sensory profile and lower irritation potential than propylene glycol. Used in sensitive-skin formulations.. It is classified as a Humectant in our database. CAS number: 107-88-0.
What is the Margin of Safety for Butylene Glycol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Butylene Glycol?
The NOAEL (No Observed Adverse Effect Level) for Butylene Glycol is 750 mg/kg bw/day based on a Chronic study via oral route in dog. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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