NOAEL Studies Cosmetic Ingredient

Butylethanolamine NOAEL Studies

INCI: BUTYLETHANOLAMINE

CAS: 111-75-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1150 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_1060; row=16483; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol, 2-(butylamino)-; preferred_name=Butylethanolamine; dtxsid=DTXSID9059410; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9059410; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 <1310 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_1061; row=16484; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol, 2-(butylamino)-; preferred_name=Butylethanolamine; dtxsid=DTXSID9059410; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9059410; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >892 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_1059; row=16485; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol, 2-(butylamino)-; preferred_name=Butylethanolamine; dtxsid=DTXSID9059410; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9059410; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =280 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabbae4b0a7c65d1bb7e5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5529/7/9/3?documentUUID=14724c9a-502f-442c-881c-2249c72a4729; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15824067:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ff1c023996a7f8192af4dc322941b51e
ToxValDB_ECHA_IUCLID NOAEL =120 mg/kg bw/day Rat oral subchronic (developmental); 50 days reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d2204b3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5529/7/6/2?documentUUID=14724c9a-502f-442c-881c-2249c72a4729; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15847360:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_447aff6ad61f2a252c73ba6d4638b6b9
ToxValDB_ECHA_IUCLID NOAEL =240 mg/kg bw/day Rat oral subchronic (developmental); 50 days reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d2204b3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5529/7/6/2?documentUUID=14724c9a-502f-442c-881c-2249c72a4729; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15847815:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c56e5ede5bf97f559b5cddafea2cf3ce
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =11.85 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630400:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e597629b64e64ba1c61090513c992b3e
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 3IBO99KPV6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H15NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3IBO99KPV6"}
openFDA substances FDA UNII substance identifier 3IBO99KPV6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H15NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3IBO99KPV6"}
openFDA substances FDA UNII substance identifier 3IBO99KPV6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H15NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3IBO99KPV6"}
openFDA substances FDA UNII substance identifier 3IBO99KPV6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H15NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3IBO99KPV6"}