Is Butylethanolamine safe in cosmetics?
Butylethanolamine has a safety rating of "POOR" in our database. EU status: restricted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Butylethanolamine
Also known as: 3-04-00-00682, BRN 1732522, N-Butyl monoethanolamine, n-Butylaminoethanol, 2-n-Butylaminoethanol (+8 more)
INCI: BUTYLETHANOLAMINE
Butylethanolamine (CAS 111-75-1) is a cosmetic cosmetic ingredient functioning as Buffering, pH adjustment. Reported NOAEL =120 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted, max 0.5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 111-75-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Butylethanolamine is classified GHS Danger (H302, H314, H315, H318, H335, H336) in the chemicals database but is restricted in EU cosmetics at max 0.5%.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Buffering, pH adjustment
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-(butylamino)ethanol
InChIKey
LJDSTRZHPWMDPG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.5%
US US Status
permitted
US Notes
Required and critical — CPSR must demonstrate MoS ≥100 with nitrosamine risk assessment
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butylethanolamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Butylethanolamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =120 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =240 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =280 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
pH regulating agent
Expert Verdict
Expert safety assessment and concern-level summary for Butylethanolamine.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Butylethanolamine by CAS number or substance name.
Studies
3
Lowest NOAEL
120 mg/kg bw/day
Highest NOAEL
280 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
3-04-00-00682
BRN 1732522
N-Butyl monoethanolamine
n-Butylaminoethanol
2-n-Butylaminoethanol
Butylethanalamine
n-Butylethanolamine
Butyl(2-hydroxyethyl)amine
Butylmonoethanolamine
EINECS 203-904-5
2-(N-Monobutylamino)ethanol
NSC 1098
UNII-3IBO99KPV6
Chemical Function
pH regulating agent
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Butylethanolamine allowed in the EU?
Butylethanolamine EU regulatory status: restricted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Butylethanolamine do in cosmetics?
Butylethanolamine functions as: Buffering, pH adjustment. It is classified as a cosmetic ingredient in our database. CAS number: 111-75-1.
What is the NOAEL for Butylethanolamine?
The NOAEL (No Observed Adverse Effect Level) for Butylethanolamine is =120 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Butylethanolamine used outside cosmetics?
Butylethanolamine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Butylethanolamine have different safety status in cosmetics vs industrial chemicals?
Butylethanolamine is classified GHS Danger (H302, H314, H315, H318, H335, H336) in the chemicals database but is restricted in EU cosmetics at max 0.5%.
Compliance Tools
Check Butylethanolamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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