NOAEL Studies
Cosmetic Ingredient
BUTYLPHENYL METHYLPROPIONAL NOAEL Studies
CAS: 80-54-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP ICE acute oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =1390 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_10525; row=15682; data_type=In Vivo; mixture=Chemical; chemical_name=3-(4-tert-Butylphenyl)-2-methylpropanal; preferred_name=2-(4-Tert-Butylbenzyl)propionaldehyde; dtxsid=DTXSID9026500; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500; source_file=acute_oral.xlsx |
NTP ICE endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 29.0629838481264 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=1458; RecordID=ERPathway2016_474; DatasetName=ERPathway2016; DTXSID=DTXSID9026500; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=29.0629838481264; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE endocrine | ACC | 24.5108899606255 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=1459; RecordID=ERPathway2016_474; DatasetName=ERPathway2016; DTXSID=DTXSID9026500; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=24.5108899606255; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=1454; RecordID=ARPathway2016_1606; DatasetName=ARPathway2016; DTXSID=DTXSID9026500; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE endocrine | Model Score | 0.0022 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=1460; RecordID=ERPathway2016_474; DatasetName=ERPathway2016; DTXSID=DTXSID9026500; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0022; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
NTP ICE eye irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | GHS Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2792; Record_ID=eye_irritation_87; Data_Type=In Vivo; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
NTP ICE skin irritation 26 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | ET50 | 147 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=5974; Record_ID=skin_irritation_invitro_1579; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiDerm Irritation; Endpoint=ET50; Response=147; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | ET50 | 154 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=5973; Record_ID=skin_irritation_invitro_1580; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiDerm Irritation; Endpoint=ET50; Response=154; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | ET50 | 162 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=5972; Record_ID=skin_irritation_invitro_1582; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiDerm Irritation; Endpoint=ET50; Response=162; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | ET50 | 176 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=5971; Record_ID=skin_irritation_invitro_1583; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiDerm Irritation; Endpoint=ET50; Response=176; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | ET50 | 179 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=5970; Record_ID=skin_irritation_invitro_1585; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiDerm Irritation; Endpoint=ET50; Response=179; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | ET50 | 186 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=5949; Record_ID=skin_irritation_invitro_1587; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiDerm Irritation; Endpoint=ET50; Response=186; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | ET50 | 195 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=5948; Record_ID=skin_irritation_invitro_1589; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiDerm Irritation; Endpoint=ET50; Response=195; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | ET50 | 196 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=5947; Record_ID=skin_irritation_invitro_1590; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiDerm Irritation; Endpoint=ET50; Response=196; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | ET50 | 201 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=5946; Record_ID=skin_irritation_invitro_1592; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiDerm Irritation; Endpoint=ET50; Response=201; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability | 7.4 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=6000; Record_ID=skin_irritation_invitro_1286; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiDerm Irritation; Endpoint=Viability; Response=7.4; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability | 8.6 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=5987; Record_ID=skin_irritation_invitro_1269; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiSkin Irritation; Endpoint=Viability; Response=8.6; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability | 9.1 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=5977; Record_ID=skin_irritation_invitro_1288; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiDerm Irritation; Endpoint=Viability; Response=9.1; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability | 11.3 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=5984; Record_ID=skin_irritation_invitro_1274; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiSkin Irritation; Endpoint=Viability; Response=11.3; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability | 11.4 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=5976; Record_ID=skin_irritation_invitro_1290; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiDerm Irritation; Endpoint=Viability; Response=11.4; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability | 11.8 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=5989; Record_ID=skin_irritation_invitro_1266; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiDerm Irritation; Endpoint=Viability; Response=11.8; Response_Unit=%; Reference=Kandarova et al. 2004; 15329774; Not available|Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability | 12.6 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=5982; Record_ID=skin_irritation_invitro_1278; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiSkin Irritation; Endpoint=Viability; Response=12.6; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability | 12.8 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=5988; Record_ID=skin_irritation_invitro_1267; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiDerm Irritation; Endpoint=Viability; Response=12.8; Response_Unit=%; Reference=Kandarova et al. 2004; 15329774; Not available|Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability | 16.7 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=5981; Record_ID=skin_irritation_invitro_1280; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiSkin Irritation; Endpoint=Viability; Response=16.7; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability | 18.9 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=5963; Record_ID=skin_irritation_invitro_1282; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiSkin Irritation; Endpoint=Viability; Response=18.90; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability | 20.8 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=5979; Record_ID=skin_irritation_invitro_1284; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiSkin Irritation; Endpoint=Viability; Response=20.8; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability | 22.93 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=5966; Record_ID=skin_irritation_invitro_1262; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiSkin Irritation; Endpoint=Viability; Response=22.93; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability | 25 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=5986; Record_ID=skin_irritation_invitro_1270; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiSkin Irritation; Endpoint=Viability; Response=25; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability | 25.9 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=5985; Record_ID=skin_irritation_invitro_1272; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiSkin Irritation; Endpoint=Viability; Response=25.9; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability | 55.56 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=5980; Record_ID=skin_irritation_invitro_1264; Data_Type=In Vitro; Formulation_Name=Lilestralis/Lilial; Concentration=97.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=EpiSkin Irritation; Endpoint=Viability; Response=55.56; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability (18 hours) | 4.8 | % | - | Dermal | - | In Vitro; Vitrolife-Skin Irritation | sheet=Data_invitro; excel_row=5992; Record_ID=skin_irritation_invitro_220; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (18 hours); Response=4.8; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin irritation | Viability (42 hours) | 5.4 | % | - | Dermal | - | In Vitro; Vitrolife-Skin Irritation | sheet=Data_invitro; excel_row=5994; Record_ID=skin_irritation_invitro_220; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (42 hours); Response=5.4; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
NTP ICE skin sensitization 26 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 44.6 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2110; Record_ID=skin_sensitization_invitro_524; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=44.6; Reported_Response_Unit=ug/mL; Response=44.6; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | CD86, EC150 | 6.1 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8218; Record_ID=skin_sensitization_invitro_2241; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=29.85659048; Reported_Response_Unit=uM; Conversion_Factor_Value=204.313; Conversion_Factor_Source=EPA Dashboard; Converted_Response=6.1; Converted_Response_Unit=ug/mL; Response=6.1; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | CD86, EC150 | 8.93 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8598; Record_ID=skin_sensitization_invitro_2375; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=8.93; Reported_Response_Unit=ug/mL; Response=8.93; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | CV70 | 34.16 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8597; Record_ID=skin_sensitization_invitro_2375; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=U-SENS; Endpoint=CV70; Reported_Response=34.16; Reported_Response_Unit=ug/mL; Response=34.16; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | CV75 | 42.2 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2109; Record_ID=skin_sensitization_invitro_524; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=h-CLAT; Endpoint=CV75; Reported_Response=42.2; Reported_Response_Unit=ug/mL; Response=42.2; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 281.25 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10538; Record_ID=skin_sensitization_invivo_2315; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=281.25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Cocchiara and Api 2003; Not available; Not available|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Concentration, one positive response | 25 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10534; Record_ID=skin_sensitization_invivo_2315; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Cocchiara and Api 2003; Not available; Not available|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Depletion Cys | -1.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=762; Record_ID=skin_sensitization_invitro_214; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-1.3; Reported_Response_Unit=%; Response=-1.3; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Depletion Cys | 14 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=758; Record_ID=skin_sensitization_invitro_213; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=14; Reported_Response_Unit=%; Response=14; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Depletion Lys | 0.7 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=757; Record_ID=skin_sensitization_invitro_213; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.7; Reported_Response_Unit=%; Response=0.7; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Depletion Lys | 0.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=761; Record_ID=skin_sensitization_invitro_214; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.8; Reported_Response_Unit=%; Response=0.8; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 0.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=763; Record_ID=skin_sensitization_invitro_214; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.4; Reported_Response_Unit=%; Response=0.4; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 7.35 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=759; Record_ID=skin_sensitization_invitro_213; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=7.35; Reported_Response_Unit=%; Response=7.35; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6800; Record_ID=skin_sensitization_invitro_1615; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Joint Research Centre of the European Union 2014|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | EC3 | 18.7 | % | Mouse | Dermal | - | In Vivo; Urbisch_SkinSensitization2020; LLNA | sheet=Data_invivo; excel_row=12920; Record_ID=skin_sensitization_invivo_2850; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=LLNA; Endpoint=EC3; Response=18.7; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | EC3 | 19 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13419; Record_ID=skin_sensitization_invivo_3562; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=LLNA; Endpoint=EC3; Response=19; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 2001; 11553118; 10.1034/j.1600-0536.2001.045002089.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | IC50 | 94.49 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6805; Record_ID=skin_sensitization_invitro_1615; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=94.49; Reported_Response_Unit=uM; Response=94.49; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Joint Research Centre of the European Union 2014|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Imax | 1.15 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6807; Record_ID=skin_sensitization_invitro_1615; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1499999999999999; Reported_Response_Unit=Unitless; Response=1.15; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Joint Research Centre of the European Union 2014|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10513; Record_ID=skin_sensitization_invivo_2311; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80063-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Incidence of positive responses | 0.4444 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10529; Record_ID=skin_sensitization_invivo_2315; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0.4444; Response_Unit=%; Species=Human; Route=Dermal; Reference=Cocchiara and Api 2003; Not available; Not available|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Induction dose per skin area | 2592 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10511; Record_ID=skin_sensitization_invivo_2311; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80063-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Induction dose per skin area | 3240 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10518; Record_ID=skin_sensitization_invivo_2313; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=3240; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80063-7|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Induction dose per skin area | 29528 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10527; Record_ID=skin_sensitization_invivo_2315; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=29528; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Cocchiara and Api 2003; Not available; Not available|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 332178.75 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10539; Record_ID=skin_sensitization_invivo_2315; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=332178.75; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Cocchiara and Api 2003; Not available; Not available|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | 29527 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10536; Record_ID=skin_sensitization_invivo_2315; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=29527; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Cocchiara and Api 2003; Not available; Not available|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10517; Record_ID=skin_sensitization_invivo_2311; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026500; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80063-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026500 |
SCCS Opinion 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.0281 | mg/kg bw | rat | oral | - | NOAEL study | p.48 |
| SCCS Opinion | NOAEL | =1.4 | mg/kg bw | rat | oral | 90-day | NOAEL study | p.40 |
| SCCS Opinion | NOAEL | =4.5 | mg/kg bw/d | - | - | developmental | reproductive toxicity | p.40 |
| SCCS Opinion | NOAEL | =5 | mg/kg bw/day | rat | oral | 90 days | reproductive toxicity | p.25 |
| SCCS Opinion | NOAEL | =5 | mg/kg bw/d | rat | oral | 90-day | NOAEL study | p.40 |
| SCCS Opinion | NOAEL | =5 | mg/kg bw/day | rat | oral | 90 days | repeated dose toxicity | p.20 |
| SCCS Opinion | NOAEL | =10 | mg/kg bw/d | rat | oral | developmental | reproductive toxicity | p.40 |
| SCCS Opinion | NOAEL | =14.5 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.30 |
| SCCS Opinion | NOAEL | =25 | mg/kg bw/day | rat | oral | Subacute | repeated dose toxicity | (refs.: Givaudan, 1991, RIFM #16176), p.21 |
| SCCS Opinion | NOAEL | =25 | mg/kg bw/day | rat | - | 5 days | repeated dose toxicity | p.34 |
| SCCS Opinion | NOAEL | =28.7 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.30 |
| SCCS Opinion | NOAEL | =29 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.30 |
| SCCS Opinion | NOAEL | =40 | mg/kg bw/day | rat | - | 5 days | reproductive toxicity | p.31 |
| SCCS Opinion | NOAEL | =40 | mg/kg bw/day | rat | - | 2 weeks | developmental toxicity | p.35 |
| SCCS Opinion | NOAEL | =45 | mg/kg bw/d | rat | - | Developmental | repeated dose toxicity | p.41 |
| SCCS Opinion | NOAEL | =50 | mg/kg bw/day | rat | oral | subacute | repeated dose toxicity | p.44 |
| SCCS Opinion | NOAEL | =50 | % | human | oral | - | NOAEL study | p.52 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =0.44 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630407:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_34eb0bfa11dc5619c23ef1e060ed4dfd |
Regulatory source 35 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | =0.0281 | mg/kg bw | rat | oral | - | - | p.48 |
| Regulatory source | - | =1.4 | mg/kg bw | rat | oral | 90-day | - | p.40 |
| Regulatory source | - | =5 | mg/kg bw/d | rat | oral | 90-day | - | p.40 |
| Regulatory source | - | 5 | mg/kg bw/d | - | - | - | - | p.41 |
| Regulatory source | - | 50 | % | human | oral | - | - | p.52 |
| Regulatory source | dermal absorption | 5 | mg/kg bw/day | human | dermal | - | dermal absorption | p.40 |
| Regulatory source | developmental toxicity | 5 | mg/kg bw/day | rat | - | 2 weeks | developmental toxicity | p.44 |
| Regulatory source | developmental toxicity | 10 | mg/kg bw/d | rat | oral | developmental | developmental toxicity | p.40 |
| Regulatory source | developmental toxicity | 40 | mg/kg bw/day | rat | - | 2 weeks | developmental toxicity | p.32 |
| Regulatory source | repeated dose toxicity | 4.5 | mg/kg bw/d | rat | oral | developmental | repeated dose toxicity | p.41 |
| Regulatory source | repeated dose toxicity | 5 | mg/kg bw/day | rat | - | Prenatal | repeated dose toxicity | p.31 |
| Regulatory source | repeated dose toxicity | 5 | mg/kg bw/day | rat | - | 2 weeks | repeated dose toxicity | p.32 |
| Regulatory source | repeated dose toxicity | 5 | mg/kg bw/day | rat | oral | 2 weeks | repeated dose toxicity | p.44 |
| Regulatory source | repeated dose toxicity | 5 | mg/kg bw/day | rat | oral | 90 days | repeated dose toxicity | p.20 |
| Regulatory source | repeated dose toxicity | 25 | mg/kg bw/day | rat | oral | Subacute | repeated dose toxicity | p.21 |
| Regulatory source | repeated dose toxicity | 25 | mg/kg bw/day | rat | - | 4 week | repeated dose toxicity | p.24 |
| Regulatory source | repeated dose toxicity | 25 | mg/kg bw/day | rat | - | prenatal | repeated dose toxicity | p.31 |
| Regulatory source | repeated dose toxicity | 25 | mg/kg bw/day | rat | oral | 5 days | repeated dose toxicity | p.44 |
| Regulatory source | repeated dose toxicity | 25 | mg/kg bw/day | rat | - | 5 days | repeated dose toxicity | p.44 |
| Regulatory source | repeated dose toxicity | 40 | mg/kg bw/day | rat | - | 5 days | repeated dose toxicity | p.44 |
| Regulatory source | repeated dose toxicity | 45 | mg/kg bw/d | rat | - | Developmental | repeated dose toxicity | p.41 |
| Regulatory source | repeated dose toxicity | 50 | mg/kg bw/day | rat | oral | subacute | repeated dose toxicity | p.44 |
| Regulatory source | reproductive toxicity | 4.5 | mg/kg bw/d | - | - | developmental | reproductive toxicity | p.40 |
| Regulatory source | reproductive toxicity | 5 | mg/kg bw/day | rat | oral | 90 days | reproductive toxicity | p.25 |
| Regulatory source | reproductive toxicity | 5 | mg/kg bw/day | rat | oral | 90-day | reproductive toxicity | p.30 |
| Regulatory source | reproductive toxicity | 10 | mg/kg bw/d | rat | oral | developmental | reproductive toxicity | p.40 |
| Regulatory source | reproductive toxicity | 10 | mg/kg bw/d | - | oral | developmental | reproductive toxicity | p.40 |
| Regulatory source | reproductive toxicity | 10 | mg/kg bw/d | - | - | developmental | reproductive toxicity | p.40 |
| Regulatory source | reproductive toxicity | 10 | mg/kg bw/d | rat | oral | - | reproductive toxicity | p.50 |
| Regulatory source | reproductive toxicity | 10 | mg/kg bw/d | rabbit | oral | developmental | reproductive toxicity | p.50 |
| Regulatory source | reproductive toxicity | ~14.5 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.30 |
| Regulatory source | reproductive toxicity | 25 | mg/kg bw/day | rat | - | developmental | reproductive toxicity | p.30 |
| Regulatory source | reproductive toxicity | ~28.7 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.30 |
| Regulatory source | reproductive toxicity | ~29 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.30 |
| Regulatory source | reproductive toxicity | 40 | mg/kg bw/day | rat | - | 5 days | reproductive toxicity | p.31 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | T7540GJV69 | UNII | - | - | - | chemical | - |