Is BUTYLPHENYL METHYLPROPIONAL safe in cosmetics?
BUTYLPHENYL METHYLPROPIONAL has a safety rating of "MODERATE" in our database. EU status: restricted. 10 toxicological study endpoint(s) are available in our database.
BUTYLPHENYL METHYLPROPIONAL
Also known as: Benzenepropanal, 4-(1,1-dimethylethyl)-alpha-methyl- (2-(4-tert-Butylbenzyl)propionaldehyde) (3-(4-tert-butylphenyl)-2-methylpropanal), Lilial, Benzenepropanal, 4-(1,1-dimethylethyl)-.alpha.-methyl-, Benzenepropanal, 4-(1,1-dimethylethyl)-alpha-methyl-, 4-07-00-00802 (+10 more)
BUTYLPHENYL METHYLPROPIONAL (CAS 80-54-6) is a cosmetic cosmetic ingredient functioning as Fragrance, Perfuming. NOAEL 2.25 mg/kg bw/day (primary-source verified against the SCCS opinion); EU Regulation 1223/2009 status: restricted, max III/83. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Cross-Vertical Regulatory Divergence
BUTYLPHENYL METHYLPROPIONAL is classified GHS Danger (H302, H315, H317, H360Fd, H361, H411, H412, H336) in the chemicals database but is restricted in EU cosmetics at max III/83.
Source: Cosmetics: ingredients.eu status/eu max; Chemicals: ghs classifications.signal word/hazard statement code
Function
Fragrance, Perfuming
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
3-(4-tert-butylphenyl)-2-methylpropanal
InChIKey
SDQFDHOLCGWZPU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
III/83
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
10 study endpoints found for BUTYLPHENYL METHYLPROPIONAL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.0281 mg/kg bw | oral | rat | NOAEL study | SCCS Opinion |
| NOAEL | =0.0281 mg/kg bw | oral | rat | NOAEL study | SCCS Opinion |
| NOAEL | =0.0281 mg/kg bw | oral | rat | NOAEL study | SCCS Opinion |
| NOAEL | =0.0281 mg/kg bw | oral | rat | NOAEL study | SCCS Opinion |
| NOAEL | =1.4 mg/kg bw | oral | rat | NOAEL study | SCCS Opinion |
| NOAEL | =1.4 mg/kg bw | oral | rat | NOAEL study | SCCS Opinion |
| NOAEL | =1.4 mg/kg bw | oral | rat | NOAEL study | SCCS Opinion |
| NOAEL | =1.4 mg/kg bw | oral | rat | NOAEL study | SCCS Opinion |
| NOAEL | =4.5 mg/kg bw/d | - | - | reproductive toxicity | SCCS Opinion |
| NOAEL | =4.5 mg/kg bw/d | - | - | reproductive toxicity | SCCS Opinion |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for BUTYLPHENYL METHYLPROPIONAL across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for BUTYLPHENYL METHYLPROPIONAL based on clinical patch test studies and IFRA standards.
Sensitization Rate
moderate
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
1.5%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted
Source: SCCS Opinion
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health Hazard
Hazard Class and Category
Repr. 1B
Hazard Statements
- H360Fd
Inserted via ATP: ATP15
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
10.6%
DPRA Lys %
0.79%
KeratinoSens IC50
172.5 µM
hCLAT CV75
39.4 µg/mL
LLNA EC3
8.6%
NESIL
2592 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Human: positive
Source: LLNA: RIFM (RIFM DB #38311) | RIFM (RIFM DB #37065); DPRA: Gerberick et al. 2007 [DOI:10.1093/toxsci/kfm064] | Nukada et al. 2013 [DOI:10.1016/j.tiv.2012.11.006]; KS: Natsch et al. 2013 [DOI:10.1002/jat.2868] | Unilever commissioned, Covance; hCLAT: Ashikaga et al. 2010 [DOI:10.1177/026119291003800403] | Unilever commissioned, IIVS; HPPT: [278] Kligman AM (1972): Report to RIFM, 18 February, unpublished.
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 119 | 2 | 29525 | - | - |
| HRIPT | 106 | 0 | 29525 | 29525 | non-sensitizer |
| HMT | - | 0 | 2592 | - | - |
| HMT | - | 0 | 3240 | - | - |
| HRIPT | - | 0 | 29528 | - | - |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Suspected
Evidence: Moderate
(2019)
Health effects: Yes
Affected pathways: Estrogenic
Regulatory framework: Cosmetics
Source list: II
Cosmetic-Specific Mechanism
Category: fragrance
Receptor targets: ERα
LOEC: 10 µM
EU status: banned (CMR 1B reproductive toxicant; Annex II from March 2022)
agonist (weak)
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1666
(EU) 2021/1902
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
JPKR Japan/Korea Cosmetics
Korea (Restricted): max 0.14
BRIN Brazil/India Cosmetics
Brazil: Restricted (Fragrance Allergen) · max >0.001% leave-on / >0.01% rinse-off requires labeling
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (6)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| AU | restricted | 0.14 | fragrances |
| UK | banned | - | - |
| UK | restricted | - | - |
| ID | banned | - | All cosmetic products prohibited |
| ID | banned | 0% | All cosmetic products |
| TH | banned | 0% | All cosmetic products |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (3 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 5.0% | - | - | SCCS/1591/17 |
| measured_sccs_opinion | 5.0% | - | - | SCCS/1540/14 |
| measured_sccs_opinion | 10.5% | - | - | Opinion on the safety of Butylphenyl methylpropional (p-BMHCA) in cosmetic products - Submission II |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Fragrance
Preservative
Regulatory List Membership (3)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
EU CosIng Cosmetics Ingredient Database
Editorial summary
Preliminary editorial summary for BUTYLPHENYL METHYLPROPIONAL — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
cosing-sourced
eu-restricted
fragrance
needs-enrichment
eu_children_restricted
ifra_fragrance
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to BUTYLPHENYL METHYLPROPIONAL by CAS number or substance name.
Studies
68
Lowest NOAEL
0.0281
Highest NOAEL
50
Units vary across source rows: mg/kg bw, mg/kg bw/d, mg/kg bw/day
SCCS Opinion
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 5.0% | SCCS opinion extraction | - |
| 5.0% | SCCS opinion extraction | - |
| 10.5% | SCCS opinion extraction | - |
Known Synonyms
Benzenepropanal, 4-(1,1-dimethylethyl)-alpha-methyl- (2-(4-tert-Butylbenzyl)propionaldehyde) (3-(4-tert-butylphenyl)-2-methylpropanal)
Lilial
Benzenepropanal, 4-(1,1-dimethylethyl)-.alpha.-methyl-
Benzenepropanal, 4-(1,1-dimethylethyl)-alpha-methyl-
4-07-00-00802
BRN 0880140
p-tert-Butyl-alpha-methyldihydrocinnamic aldehyde
p-tert-Butyl-alpha-methylhydrocinnamaldehyde
p-tert-Butyl-alpha-methylhydrocinnamic aldehyde
EINECS 201-289-8
alpha-Methyl, beta-(p-tert-butylphenyl)propionaldehyde
alpha-Methyl-p-(tert-butyl)hydrocinnamaldehyde
NSC 22275
Propionaldehyde, beta-(4-tert-butylphenyl)-alpha-methyl-
UNII-T7540GJV69
Chemical Function
Fragrance
Regulatory Lists
Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener
Europe
inert_ingredient; non_food_use; Pesticides
children; Europe; Personal care - specialized bath products - bath salts
children; Europe; Personal care - specialized bath products - bubble bath
Europe; Personal care - body hygiene - hand soap
children; Europe; Personal care
children; Europe; Personal care
children; Europe; Personal care
children; Europe; Personal care
Europe; Personal care - deodorant
Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe
Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe
Cleaning products and household care; Europe
Cleaning products and household care - air freshener; Europe
air; Cleaning products and household care - air freshener; detected; emissions; Europe
Cleaning products and household care - air freshener; Europe
Cleaning products and household care - dishwasher and dishes; Cleaning products and household care - general household cleaning; Cleaning products and household care - laundry and fabric treatment; detected; Europe; Other direct contact consumer goods
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1496715
Frequently Asked Questions
Is BUTYLPHENYL METHYLPROPIONAL allowed in the EU?
BUTYLPHENYL METHYLPROPIONAL EU regulatory status: restricted. Maximum allowed concentration: III/83. This is based on EU Regulation 1223/2009 and its amendments.
What does BUTYLPHENYL METHYLPROPIONAL do in cosmetics?
BUTYLPHENYL METHYLPROPIONAL functions as: Fragrance, Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 80-54-6.
What is the NOAEL for BUTYLPHENYL METHYLPROPIONAL?
The NOAEL (No Observed Adverse Effect Level) for BUTYLPHENYL METHYLPROPIONAL is =0.0281 mg/kg bw based on a NOAEL study study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS Opinion.
Is BUTYLPHENYL METHYLPROPIONAL used outside cosmetics?
BUTYLPHENYL METHYLPROPIONAL also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does BUTYLPHENYL METHYLPROPIONAL have different safety status in cosmetics vs industrial chemicals?
BUTYLPHENYL METHYLPROPIONAL is classified GHS Danger (H302, H315, H317, H360Fd, H361, H411, H412, H336) in the chemicals database but is restricted in EU cosmetics at max III/83.
Compliance Tools
Check BUTYLPHENYL METHYLPROPIONAL compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
EXCELLENT
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
EXCELLENT
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
EXCELLENT
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
EXCELLENT
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
EXCELLENT
Same category
Fragrance
Acetoin
EXCELLENT
Same category
Skin conditioning, fragrance
(20S)-Protopanaxadiol
MODERATE
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
MODERATE
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
MODERATE
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
MODERATE
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
MODERATE
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
MODERATE
Similar safety
Skin conditioning, antioxidant
1-Methyl-4-methylvinyl-cyclohexyl Acetate
GOOD
Chemical family
Perfuming (herbal/lavender character;...
4,4'-ISOPROPYLIDENEDIPHENOL
MODERATE
Chemical family
Not Reported
4,4'-Isopropylidenediphenol (Bisphenol A / BPA)
POOR
Chemical family
Not a functional cosmetic ingredient;...
Is BUTYLPHENYL METHYLPROPIONAL in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for BUTYLPHENYL METHYLPROPIONAL in your formulation.