C12-13 Pareth-3
INCI: C12-13 PARETH-3 (NEW: C12-13 ALKETH-3)
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for C12-13 Pareth-3. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Primary risk is residual 1,4-dioxane and ethylene oxide contamination from the ethoxylation process; vacuum stripping is standard mitigation. May enhance skin penetration of other ingredients due to surfactant action. Nonionic surfactant with 3 moles average EO. Relatively low HLB - good for W/O emulsions and oil-based cleansers. Synthetic origin
Regulatory Flags
Frequently Asked Questions
Is C12-13 Pareth-3 safe in cosmetics?
Primary risk is residual 1,4-dioxane and ethylene oxide contamination from the ethoxylation process; vacuum stripping is standard mitigation. May enhance skin penetration of other ingredients due to surfactant action. Nonionic surfactant with 3 moles average EO. Relatively low HLB - good for W/O emulsions and oil-based cleansers. Synthetic origin The EU classifies C12-13 Pareth-3 as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is C12-13 Pareth-3 allowed in the EU?
C12-13 Pareth-3 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does C12-13 Pareth-3 do in cosmetics?
C12-13 Pareth-3 functions as: Surfactant - cleansing; surfactant - emulsifying; fragrance functional (excipient for perfume oils). It is classified as a cosmetic ingredient in our database. CAS number: 66455-14-9.
What is the Margin of Safety for C12-13 Pareth-3?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for C12-13 Pareth-3?
The NOAEL (No Observed Adverse Effect Level) for C12-13 Pareth-3 is 500 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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