C12-15 Pareth-2
INCI: C12-15 PARETH-2 (NEW: C12-15 ALKETH-2)
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for C12-15 Pareth-2. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=1000 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | >=150 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | 750 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | >=2000 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | - | oral | REACH |
Expert Verdict
1,4-dioxane and ethylene oxide residue risk. Low water solubility (21 mg/L at 20 °C) - more lipophilic, potential for stronger defatting of skin at high concentrations. Nonionic, only 2 moles average EO - very low HLB, strongly lipophilic. Excellent wetting and penetrating properties. Density ~0.93 g/cm³ at 20 °C. Often used as a co-surfactant rather than a standalone emulsifier
Regulatory Flags
Frequently Asked Questions
Is C12-15 Pareth-2 safe in cosmetics?
1,4-dioxane and ethylene oxide residue risk. Low water solubility (21 mg/L at 20 °C) - more lipophilic, potential for stronger defatting of skin at high concentrations. Nonionic, only 2 moles average EO - very low HLB, strongly lipophilic. Excellent wetting and penetrating properties. Density ~0.93 g/cm³ at 20 °C. Often used as a co-surfactant rather than a standalone emulsifier The EU classifies C12-15 Pareth-2 as "permitted". Safety rating: MODERATE. 6 toxicological study endpoint(s) are available in our database.
Is C12-15 Pareth-2 allowed in the EU?
C12-15 Pareth-2 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does C12-15 Pareth-2 do in cosmetics?
C12-15 Pareth-2 functions as: Surfactant - cleansing; surfactant - emulsifying; wetting agent. It is classified as a cosmetic ingredient in our database. CAS number: 68131-39-5.
What is the Margin of Safety for C12-15 Pareth-2?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for C12-15 Pareth-2?
The NOAEL (No Observed Adverse Effect Level) for C12-15 Pareth-2 is >=500 mg/kg bw/day based on a oral study via oral route in rat. A total of 6 study endpoints are available. Source: REACH.
Compliance Tools
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