Good Cosmetic Ingredient NOAEL Data

PEG/PPG-16/17 Copolymer

INCI: PEG/PPG-16/17 COPOLYMER

CAS Number

9003-11-6

Function

Surfactant, solvent, viscosity controlling

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status permitted

🇺🇸 US Status permitted

US Notes Poloxamer class; CIR reviewed; note: CIR flagged PEG/PPG-17/6 for further study

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

moderate

Sensitization

low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for PEG/PPG-16/17 Copolymer. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	25000 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
NOAEL	30000 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
NOAEL	480 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
NOAEL	3000 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
NOAEL	1000 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	200 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	500 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	1000 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	1000 mg/kg bw/day	oral	dog	Subchronic	COSMOS_DB
NOAEL	40 mg/kg bw/day	oral	dog	Subchronic	COSMOS_DB

Expert Verdict

⚠️

Concern Level: Low

Regulatory Flags

peg-ingredient epa_safer_alternative fda_food_additive

Frequently Asked Questions

Is PEG/PPG-16/17 Copolymer safe in cosmetics?

PEG/PPG copolymer surfactant with adequate safety margin; 1,4-dioxane impurity possible in synthesis; CIR noted similar PEG/PPG-17/6 ratio warrants further study, so apply caution to adjacent molecular ratios. The EU classifies PEG/PPG-16/17 Copolymer as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is PEG/PPG-16/17 Copolymer allowed in the EU?

PEG/PPG-16/17 Copolymer EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does PEG/PPG-16/17 Copolymer do in cosmetics?

PEG/PPG-16/17 Copolymer functions as: Surfactant, solvent, viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 9003-11-6.

What is the Margin of Safety for PEG/PPG-16/17 Copolymer?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for PEG/PPG-16/17 Copolymer?

The NOAEL (No Observed Adverse Effect Level) for PEG/PPG-16/17 Copolymer is 25000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check PEG/PPG-16/17 Copolymer compliance across multiple jurisdictions:

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Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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