Good Cosmetic Ingredient NOAEL Data

CALCIUM ASCORBATE

CAS Number

5743-27-1

Function

Antioxidant, Skin Conditioning

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status Permitted

🇺🇸 US Status permitted

US Notes CIR: S - IJT 24(Suppl. 2):51-111, 2005

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

7 study endpoints found for CALCIUM ASCORBATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	2500 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	2500 mg/kg bw/day	oral	rat	Chronic	COSMOS_DB
NOAEL	2500 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
NOAEL	2000 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
dose_tested	2500 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB
dose_tested	2500 mg/kg bw/day	oral	rat	Chronic	COSMOS_DB
dose_tested	2000 mg/kg bw/day	oral	rat	Subchronic	COSMOS_DB

Expert Verdict

CALCIUM ASCORBATE is listed in the EU CosIng database with functions: Antioxidant, Skin Conditioning It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted skin-conditioning antioxidant needs-enrichment fda_food_additive jecfa_safe

Frequently Asked Questions

Is CALCIUM ASCORBATE safe in cosmetics?

CALCIUM ASCORBATE is listed in the EU CosIng database with functions: Antioxidant, Skin Conditioning It is permitted in the EU without specific restrictions. The EU classifies CALCIUM ASCORBATE as "Permitted". Safety rating: GOOD. 7 toxicological study endpoint(s) are available in our database.

Is CALCIUM ASCORBATE allowed in the EU?

CALCIUM ASCORBATE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does CALCIUM ASCORBATE do in cosmetics?

CALCIUM ASCORBATE functions as: Antioxidant, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 5743-27-1.

What is the NOAEL for CALCIUM ASCORBATE?

The NOAEL (No Observed Adverse Effect Level) for CALCIUM ASCORBATE is 2500 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 7 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

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Substance Compliance

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