Caffeine Salicylate

INCI: CAFFEINE SALICYLATE

CAS Number
5743-22-6
Function
Skin Conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 2.0%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Must be calculated based on free salicylic acid release from the salt; SCCS opinion on salicylic acid provides reference values

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Must quantify free salicylic acid release to ensure Annex III compliance; potential OTC drug classification in US if salicylic acid claims are made; not for use in products for children under 3 years; prohibited as preservative above 0.5%

โš ๏ธ
Concern Level: High

Frequently Asked Questions

Is Caffeine Salicylate safe in cosmetics?

Must quantify free salicylic acid release to ensure Annex III compliance; potential OTC drug classification in US if salicylic acid claims are made; not for use in products for children under 3 years; prohibited as preservative above 0.5% The EU classifies Caffeine Salicylate as "restricted". Safety rating: MODERATE.

Is Caffeine Salicylate allowed in the EU?

Caffeine Salicylate EU regulatory status: restricted. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.

What does Caffeine Salicylate do in cosmetics?

Caffeine Salicylate functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 5743-22-6.

What is the Margin of Safety for Caffeine Salicylate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Caffeine Salicylate in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Caffeine Salicylate in your formulation.