NOAEL Studies Cosmetic Ingredient

Calcium Carbonate NOAEL Studies

INCI: CALCIUM CARBONATE

CAS: 471-34-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 3000 mg/kg bw/day mouse oral NA Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 300 mg/kg bw/day rat oral 70 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1015 mg/kg bw/day rat oral NA Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 9989 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1349 mg/kg bw/day rat oral 22 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 385 mg/kg bw/day rat oral 63 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_7370; row=6179; data_type=In Vivo; mixture=Chemical; chemical_name=Carbonic acid calcium salt (1:1); preferred_name=Calcium carbonate; dtxsid=DTXSID3036238; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3036238; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =6450 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7372; row=6180; data_type=In Vivo; mixture=Chemical; chemical_name=Carbonic acid calcium salt (1:1); preferred_name=Calcium carbonate; dtxsid=DTXSID3036238; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3036238; source_file=acute_oral.xlsx
NTP_ICE_skin_irritation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_irritation Breakthrough Time 240 min - Dermal - In Vitro; Corrositex sheet=Data_invitro; excel_row=2631; Record_ID=skin_irritation_invitro_53; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3036238; Assay=Corrositex; Endpoint=Breakthrough Time; Response=240; Response_Unit=min; Reference=ICCVAM 1999; Not available; ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3036238
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =6.36 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630533:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_12a90a716a03c08f2f5ac36aebd2d966
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier H0G9379FGK UNII - - - chemical {"approval_status":null,"molecular_formula":"CO3.Ca","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H0G9379FGK"}
openFDA substances FDA UNII substance identifier H0G9379FGK UNII - - - chemical {"approval_status":null,"molecular_formula":"CO3.Ca","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H0G9379FGK"}
openFDA substances FDA UNII substance identifier H0G9379FGK UNII - - - chemical {"approval_status":null,"molecular_formula":"CO3.Ca","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H0G9379FGK"}
openFDA substances FDA UNII substance identifier H0G9379FGK UNII - - - chemical {"approval_status":null,"molecular_formula":"CO3.Ca","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H0G9379FGK"}