Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Calcium Carbonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 3000 mg/kg bw/day | oral | mouse | Reproductive | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1015 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 9989 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1349 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 385 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 1015 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >1000 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | >1000 mg/kg bw/day | oral | - | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Must meet Annex IV purity criteria for heavy metals (As, Pb, Hg) when used as colorant
Regulatory Flags
Frequently Asked Questions
Is Calcium Carbonate safe in cosmetics?
Must meet Annex IV purity criteria for heavy metals (As, Pb, Hg) when used as colorant The EU classifies Calcium Carbonate as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Calcium Carbonate allowed in the EU?
Calcium Carbonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Carbonate do in cosmetics?
Calcium Carbonate functions as: Abrasive, Buffering, Bulking, Opacifying, Oral Care, Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 471-34-1.
What is the Margin of Safety for Calcium Carbonate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Calcium Carbonate?
The NOAEL (No Observed Adverse Effect Level) for Calcium Carbonate is 3000 mg/kg bw/day based on a Reproductive study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Calcium Carbonate compliance across multiple jurisdictions:
Related Ingredients
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