NOAEL Studies Cosmetic Ingredient

Calcium Silicate NOAEL Studies

INCI: CALCIUM SILICATE

CAS: 1344-95-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 1600 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEC =10 mg/m3 Rat inhalation acute; 7 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14771/7/6/3?documentUUID=39be3e66-5cd2-40d4-b08e-77041e78bffc; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15828029:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c483b12efb28dc13c852be74f5125ae7
ToxValDB_ECHA_IUCLID NOAEL =1600 mg/kg bw/day Hamster oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1a6e4b0a7c65d22f8d6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14771/7/9/3?documentUUID=06371084-b72e-4b51-a61c-7356dffbaebe; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821435_15821692:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d62cb5c35936164e1339310baa211523
ToxValDB_ECHA_IUCLID NOAEL ~2500 mg/kg bw/day Rat oral chronic; 2 years chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead3fe4b0a7c65d1c3456; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14771/7/6/2?documentUUID=06371084-b72e-4b51-a61c-7356dffbaebe; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846909_15847036_15850684_15850685:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3b4c800137b468f95a50de664b035919
ToxValDB_ECHA_IUCLID NOAEL ~3200 mg/kg bw/day Rat oral chronic; 2 years chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead3fe4b0a7c65d1c3456; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14771/7/6/2?documentUUID=06371084-b72e-4b51-a61c-7356dffbaebe; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846909_15847036_15850684_15850685:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_520c71a364c6cdda772770ff64603177
ToxValDB_GESTIS_DNEL 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =10 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630840_15630841_15634622_15634623:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_292df3e7874c37901773c57e25ddb3a3
ToxValDB_GESTIS_DNEL DNEL local =4 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630840_15630841_15634622_15634623:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4050a331b03c769013953b6c8f20fc2b
ToxValDB_GESTIS_DNEL DNEL systemic =0.05 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630840_15630841_15634622_15634623:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_644c6757bef6d30b50a3843f4fbad612
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier S4255P4G5M UNII - - - chemical {"approval_status":null,"molecular_formula":"Ca.2H3O4Si","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S4255P4G5M"}
openFDA substances FDA UNII substance identifier S4255P4G5M UNII - - - chemical {"approval_status":null,"molecular_formula":"Ca.2H3O4Si","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S4255P4G5M"}
openFDA substances FDA UNII substance identifier S4255P4G5M UNII - - - chemical {"approval_status":null,"molecular_formula":"Ca.2H3O4Si","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S4255P4G5M"}
openFDA substances FDA UNII substance identifier S4255P4G5M UNII - - - chemical {"approval_status":null,"molecular_formula":"Ca.2H3O4Si","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S4255P4G5M"}