Good Cosmetic Ingredient NOAEL Data SCCS/CIR Reviewed

Calcium Stearoyl Lactylate

Also known as: Octadecanoic acid, 2-(1-carboxyethoxy)-1-methyl-2-oxoethyl ester, calcium salt (2:1), Calcium bis(2-(1-carboxylatoethoxy)-1-methyl-2-oxoethyl) distearate

INCI: CALCIUM STEAROYL LACTYLATE

Calcium Stearoyl Lactylate (CAS 5793-94-2) is a cosmetic cosmetic ingredient functioning as Surfactant — Cleansing; Surfactant — Emulsifying (W/O emulsifier). NOAEL 2200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; 2 safety opinions reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.

View industrial chemical safety profile for CAS 5793-94-2 →

Auto-generated CPSR Part A draft with source citations
Function
Surfactant — Cleansing; Surfactant — Emulsifying (W/O emulsifier)
Safety Rating
GOOD

Chemistry & Identifiers

Formula
C48H86CaO12
MW
895.3 g/mol
PubChem CID
22037
IUPAC Name
calcium bis(2-(2-octadecanoyloxypropanoyloxy)propanoate)
InChIKey
OEUVSBXAMBLPES-UHFFFAOYSA-L

Regulatory Status

EU EU Status permitted
US US Status permitted
US Notes Safety

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Calcium Stearoyl Lactylate.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

5 study endpoints found for Calcium Stearoyl Lactylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 2500 mg/kg bw/day oral rat Multigeneration Reproductive COSMOS_DB
NOAEL 5000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 7500 mg/kg bw/day oral dog Short Term Toxicity COSMOS_DB
NOAEL 12500 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 16000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir
Verdict: safe
NOAEL: 2200 mg/kg body weight/day (oral)

redients, and concluded that these 10 ingredients are safe in cosmetics in the present practices of use and concentration described in the safety assessment when formulated to be nonirritating and nonsensitizing, which may be based on a quantitative risk assessment (QRA) or other accepted method

cir
Verdict: safe
NOAEL: 2214 mg/kg/day (oral)

redients, and concluded that these 10 ingredients are safe in cosmetics in the present practices of use and concentration described in the safety assessment when formulated to be nonirritating and nonsensitizing, which may be based on a quantitative risk assessment (QRA) or other accepted method

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Calcium Stearoyl Lactylate across SCCS product categories, with measured dermal absorption where available.

Additional Ingredient Properties

3 property records from structured ingredient metadata.

emulsifier
{"cas_number": "5793-94-2", "ingredient_class": "O/W_emulsifier,PEG_free_emulsifier", "chemical_type": "amino_acid_based", "HLB_value": "10.0", "HLB_required_for_oil_phase": "8-12", "emulsion_type_primary": "O/W", "droplet_size_typical_um": "0.5-2", "critical_micelle_concentration_pct": "0.01-0.05", "surface_tension_reduction_mN_m": "33", "interfacial_tension_reduction": "37", "foam_formation": "h…
emulsion_hlb
{"hlb_value": "8.0", "hlb_required_as_emulsifier": "yes", "emulsifier_type": "o_w", "critical_packing_parameter": "0.30-0.42", "emulsion_stabilization_mechanism": "electrostatic_steric", "co_emulsifier_pairs": "glyceryl_stearate", "optimal_oil_phase_pct": "10-30", "optimal_water_phase_pct": "70-90", "electrolyte_tolerance": "very_low", "pH_emulsion_stability_range": "5.5-9.0", "viscosity_building_…
surfactant
{"cas_number": "23978-47-7", "surfactant_type": "anionic", "chemical_class": "glycinate", "charge_at_use_ph": "negative", "cmc_critical_micelle_concentration_mm": "5.397867951043108", "hlb_value": "26.0", "foam_volume_ml_ross_miles": "133", "foam_quality": "creamy", "foam_stability_5min_pct": "82", "cleansing_power_rating_1_to_10": "7.76351287370422", "oil_emulsification_capacity": "good", "sebum_…

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Regulatory (2)
JECFA Evaluation
CALCIUM STEAROYL-2-LACTYLATE | 1973 | 0-20 mg/kg bw | NMRS 53/TRS 539-JECFA 17/37 | FAS 5/NMRS 53A-JECFA 17/505
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Emulsifier Filler Surfactant (surface active agent) Thickening agent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)

Expert Verdict

Expert safety assessment and concern-level summary for Calcium Stearoyl Lactylate.

Regulatory Flags

fda_food_additive

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Calcium Stearoyl Lactylate by CAS number or substance name.

Studies
5
Lowest NOAEL
2500 mg/kg bw/day
Highest NOAEL
16000 mg/kg bw/day
COSMOS_DB

Known Synonyms

Octadecanoic acid, 2-(1-carboxyethoxy)-1-methyl-2-oxoethyl ester, calcium salt (2:1) Calcium bis(2-(1-carboxylatoethoxy)-1-methyl-2-oxoethyl) distearate

Chemical Function

Surfactant (surface active agent) Emulsifier Thickening agent Filler

Regulatory Lists

food_additive; Substances Added to Food (formerly EAFUS) (2/2019)

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in food safety data.

SOURCE EFSA / FDA GRAS food_additives

Food Safety Data

Same-CAS food additive or FDA GRAS records from the core public database.

Food Name
Calcium stearoyl-2-lactylate
E Number
E482
ADI
22 mg/kg bw
Food Category
emulsifier
View full food safety profile →

Frequently Asked Questions

Is Calcium Stearoyl Lactylate safe in cosmetics?

Calcium Stearoyl Lactylate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 5 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.

Is Calcium Stearoyl Lactylate allowed in the EU?

Calcium Stearoyl Lactylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Calcium Stearoyl Lactylate do in cosmetics?

Calcium Stearoyl Lactylate functions as: Surfactant — Cleansing; Surfactant — Emulsifying (W/O emulsifier). It is classified as a cosmetic ingredient in our database. CAS number: 5793-94-2.

What is the NOAEL for Calcium Stearoyl Lactylate?

The NOAEL (No Observed Adverse Effect Level) for Calcium Stearoyl Lactylate is 2500 mg/kg bw/day based on a Multigeneration Reproductive study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.

Is Calcium Stearoyl Lactylate used outside cosmetics?

Calcium Stearoyl Lactylate also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

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