Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Calcium Xylenesulfonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=1030 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | >763 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=2000 mg/kg bw/day | dermal | code:3543 | dermal | REACH |
| NOAEL | >=500 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | >1 other | oral | mouse | oral | REACH |
| NOAEL | >=440 mg/kg bw/day | dermal | code:3543 | dermal | REACH |
| NOAEL | >0.5 other | oral | rat | oral | REACH |
| NOEL | >2439 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | >1 other | oral | rat | oral | REACH |
Expert Verdict
Calcium Xylenesulfonate is a permitted surfactant and hydrotrope with good safety profile, low absorption, and minimal sensitization risk.
Regulatory Flags
Frequently Asked Questions
Is Calcium Xylenesulfonate safe in cosmetics?
Calcium Xylenesulfonate is a permitted surfactant and hydrotrope with good safety profile, low absorption, and minimal sensitization risk. The EU classifies Calcium Xylenesulfonate as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Calcium Xylenesulfonate allowed in the EU?
Calcium Xylenesulfonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Xylenesulfonate do in cosmetics?
Calcium Xylenesulfonate functions as: Surfactant (hydrotrope), solubilizer. It is classified as a cosmetic ingredient in our database. CAS number: 28088-63-3.
What is the Margin of Safety for Calcium Xylenesulfonate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Calcium Xylenesulfonate?
The NOAEL (No Observed Adverse Effect Level) for Calcium Xylenesulfonate is 1200 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
Check Calcium Xylenesulfonate compliance across multiple jurisdictions:
Related Ingredients
Is Calcium Xylenesulfonate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Calcium Xylenesulfonate in your formulation.