NOAEL Studies Cosmetic Ingredient

Camphene NOAEL Studies

INCI: CAMPHENE

CAS: 79-92-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 15 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 250 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=64da4833-2c9d-4e75-a80b-a68047772fd0.i6z; document=bdb83093-0c66-4108-af97-6f3992d420ed_64da4833-2c9d-4e75-a80b-a68047772fd0.i6d; document_key=bdb83093-0c66-4108-af97-6f3992d420ed/64da4833-2c9d-4e75-a80b-a68047772fd0; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-10-06; basis=other:; key_result=false; entry_uuid=6105b77d-e630-4506-bad3-e2c992caf339
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >=1000 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=64da4833-2c9d-4e75-a80b-a68047772fd0.i6z; document=bdb83093-0c66-4108-af97-6f3992d420ed_64da4833-2c9d-4e75-a80b-a68047772fd0.i6d; document_key=bdb83093-0c66-4108-af97-6f3992d420ed/64da4833-2c9d-4e75-a80b-a68047772fd0; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-10-06; basis=other:; key_result=false; entry_uuid=e2ba1e66-f06a-4657-aec2-f5b8d321078b
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >=500 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=64da4833-2c9d-4e75-a80b-a68047772fd0.i6z; document=5f3d36a1-c850-47f4-9835-9d94887addb8_64da4833-2c9d-4e75-a80b-a68047772fd0.i6d; document_key=5f3d36a1-c850-47f4-9835-9d94887addb8/64da4833-2c9d-4e75-a80b-a68047772fd0; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=false; entry_uuid=b26f2e55-77a8-4ea0-a15a-dff4c6160efa
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 250 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=64da4833-2c9d-4e75-a80b-a68047772fd0.i6z; document=bdb83093-0c66-4108-af97-6f3992d420ed_64da4833-2c9d-4e75-a80b-a68047772fd0.i6d; document_key=bdb83093-0c66-4108-af97-6f3992d420ed/64da4833-2c9d-4e75-a80b-a68047772fd0; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-10-06; basis=other:; key_result=false; entry_uuid=6105b77d-e630-4506-bad3-e2c992caf339
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >=1000 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=64da4833-2c9d-4e75-a80b-a68047772fd0.i6z; document=bdb83093-0c66-4108-af97-6f3992d420ed_64da4833-2c9d-4e75-a80b-a68047772fd0.i6d; document_key=bdb83093-0c66-4108-af97-6f3992d420ed/64da4833-2c9d-4e75-a80b-a68047772fd0; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-10-06; basis=other:; key_result=false; entry_uuid=e2ba1e66-f06a-4657-aec2-f5b8d321078b
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >=500 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=64da4833-2c9d-4e75-a80b-a68047772fd0.i6z; document=5f3d36a1-c850-47f4-9835-9d94887addb8_64da4833-2c9d-4e75-a80b-a68047772fd0.i6d; document_key=5f3d36a1-c850-47f4-9835-9d94887addb8/64da4833-2c9d-4e75-a80b-a68047772fd0; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=false; entry_uuid=b26f2e55-77a8-4ea0-a15a-dff4c6160efa
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 250 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=64da4833-2c9d-4e75-a80b-a68047772fd0.i6z; document=bdb83093-0c66-4108-af97-6f3992d420ed_64da4833-2c9d-4e75-a80b-a68047772fd0.i6d; document_key=bdb83093-0c66-4108-af97-6f3992d420ed/64da4833-2c9d-4e75-a80b-a68047772fd0; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-10-06; basis=other:; key_result=false; entry_uuid=6105b77d-e630-4506-bad3-e2c992caf339
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >=1000 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=64da4833-2c9d-4e75-a80b-a68047772fd0.i6z; document=bdb83093-0c66-4108-af97-6f3992d420ed_64da4833-2c9d-4e75-a80b-a68047772fd0.i6d; document_key=bdb83093-0c66-4108-af97-6f3992d420ed/64da4833-2c9d-4e75-a80b-a68047772fd0; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-10-06; basis=other:; key_result=false; entry_uuid=e2ba1e66-f06a-4657-aec2-f5b8d321078b
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >=500 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=64da4833-2c9d-4e75-a80b-a68047772fd0.i6z; document=5f3d36a1-c850-47f4-9835-9d94887addb8_64da4833-2c9d-4e75-a80b-a68047772fd0.i6d; document_key=5f3d36a1-c850-47f4-9835-9d94887addb8/64da4833-2c9d-4e75-a80b-a68047772fd0; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=false; entry_uuid=b26f2e55-77a8-4ea0-a15a-dff4c6160efa
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 250 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=64da4833-2c9d-4e75-a80b-a68047772fd0.i6z; document=65411004-0e2b-474a-8b6c-07c8c9b7254d_64da4833-2c9d-4e75-a80b-a68047772fd0.i6d; document_key=65411004-0e2b-474a-8b6c-07c8c9b7254d/64da4833-2c9d-4e75-a80b-a68047772fd0; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-05-02; basis=other:; key_result=false; entry_uuid=16f5607d-0cde-4e9d-816b-733e0ee4af78
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL <=62.5 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=64da4833-2c9d-4e75-a80b-a68047772fd0.i6z; document=65411004-0e2b-474a-8b6c-07c8c9b7254d_64da4833-2c9d-4e75-a80b-a68047772fd0.i6d; document_key=65411004-0e2b-474a-8b6c-07c8c9b7254d/64da4833-2c9d-4e75-a80b-a68047772fd0; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-05-02; basis=other:; key_result=false; upper_value=62.5; entry_uuid=e35c7e78-f8d5-4d4b-a3b5-1e89a36e6ac4
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 250 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=64da4833-2c9d-4e75-a80b-a68047772fd0.i6z; document=65411004-0e2b-474a-8b6c-07c8c9b7254d_64da4833-2c9d-4e75-a80b-a68047772fd0.i6d; document_key=65411004-0e2b-474a-8b6c-07c8c9b7254d/64da4833-2c9d-4e75-a80b-a68047772fd0; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-05-02; basis=other:; key_result=false; entry_uuid=16f5607d-0cde-4e9d-816b-733e0ee4af78
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL <=62.5 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=64da4833-2c9d-4e75-a80b-a68047772fd0.i6z; document=65411004-0e2b-474a-8b6c-07c8c9b7254d_64da4833-2c9d-4e75-a80b-a68047772fd0.i6d; document_key=65411004-0e2b-474a-8b6c-07c8c9b7254d/64da4833-2c9d-4e75-a80b-a68047772fd0; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-05-02; basis=other:; key_result=false; upper_value=62.5; entry_uuid=e35c7e78-f8d5-4d4b-a3b5-1e89a36e6ac4
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 250 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=64da4833-2c9d-4e75-a80b-a68047772fd0.i6z; document=65411004-0e2b-474a-8b6c-07c8c9b7254d_64da4833-2c9d-4e75-a80b-a68047772fd0.i6d; document_key=65411004-0e2b-474a-8b6c-07c8c9b7254d/64da4833-2c9d-4e75-a80b-a68047772fd0; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-05-02; basis=other:; key_result=false; entry_uuid=16f5607d-0cde-4e9d-816b-733e0ee4af78
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL <=62.5 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=64da4833-2c9d-4e75-a80b-a68047772fd0.i6z; document=65411004-0e2b-474a-8b6c-07c8c9b7254d_64da4833-2c9d-4e75-a80b-a68047772fd0.i6d; document_key=65411004-0e2b-474a-8b6c-07c8c9b7254d/64da4833-2c9d-4e75-a80b-a68047772fd0; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-05-02; basis=other:; key_result=false; upper_value=62.5; entry_uuid=e35c7e78-f8d5-4d4b-a3b5-1e89a36e6ac4
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =222 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA CEF - 2015 - OutputID 2635 - haematology - systemic - Scientific Opinion on Flavouring Group Evaluation 78, Revision 2 (FGE.78Rev2): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic hydrocarbons evaluated by EFSA in FGE.25Rev3. - doi:10.2903/j.efsa.2015.4067
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =222 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA CEF - 2015 - OutputID 2635 - haematology - systemic - Scientific Opinion on Flavouring Group Evaluation 78, Revision 2 (FGE.78Rev2): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic hydrocarbons evaluated by EFSA in FGE.25Rev3. - doi:10.2903/j.efsa.2015.4067
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_10654; row=13852; data_type=In Vivo; mixture=Chemical; chemical_name=Camphene; preferred_name=Camphene; dtxsid=DTXSID8026488; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=6214; RecordID=ARPathway2016_1592; DatasetName=ARPathway2016; DTXSID=DTXSID8026488; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation 20 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_eye_irritation EPA Classification 3 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2461; Record_ID=eye_irritation_226; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation EPA Classification 3 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2461; Record_ID=eye_irritation_226; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation EPA Classification 3 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2461; Record_ID=eye_irritation_226; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation EPA Classification 3 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2461; Record_ID=eye_irritation_226; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation GHS Classification 2 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2456; Record_ID=eye_irritation_226; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2B; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation GHS Classification 2 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2456; Record_ID=eye_irritation_226; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2B; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation GHS Classification 2 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2456; Record_ID=eye_irritation_226; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2B; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation GHS Classification 2 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2456; Record_ID=eye_irritation_226; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2B; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation Intensity 0.04 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2460; Record_ID=eye_irritation_1253; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Vitrigel; Endpoint=Intensity; Response=0.04; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation Intensity 0.04 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2460; Record_ID=eye_irritation_1253; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Vitrigel; Endpoint=Intensity; Response=0.04; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation Intensity 0.04 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2460; Record_ID=eye_irritation_1253; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Vitrigel; Endpoint=Intensity; Response=0.04; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation Intensity 0.04 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2460; Record_ID=eye_irritation_1253; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Vitrigel; Endpoint=Intensity; Response=0.04; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation Lag time 100 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2455; Record_ID=eye_irritation_1253; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Vitrigel; Endpoint=Lag time; Response=100; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation Lag time 100 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2455; Record_ID=eye_irritation_1253; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Vitrigel; Endpoint=Lag time; Response=100; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation Lag time 100 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2455; Record_ID=eye_irritation_1253; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Vitrigel; Endpoint=Lag time; Response=100; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation Lag time 100 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2455; Record_ID=eye_irritation_1253; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Vitrigel; Endpoint=Lag time; Response=100; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation Plateau level 4 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2459; Record_ID=eye_irritation_1253; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Vitrigel; Endpoint=Plateau level; Response=4; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation Plateau level 4 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2459; Record_ID=eye_irritation_1253; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Vitrigel; Endpoint=Plateau level; Response=4; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation Plateau level 4 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2459; Record_ID=eye_irritation_1253; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Vitrigel; Endpoint=Plateau level; Response=4; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_eye_irritation Plateau level 4 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2459; Record_ID=eye_irritation_1253; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Vitrigel; Endpoint=Plateau level; Response=4; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10349; Record_ID=skin_sensitization_invivo_2277; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90199-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_skin_sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10347; Record_ID=skin_sensitization_invivo_2277; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90199-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10352; Record_ID=skin_sensitization_invivo_2277; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8026488; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90199-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8026488
ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL <1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf1b2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14290/7/9/3?documentUUID=64da4833-2c9d-4e75-a80b-a68047772fd0; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822893_15823061_15823837_15823865:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0517e154c83378a99d88f2f2cea34572
ToxValDB_ECHA_IUCLID NOAEL =250 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf1b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14290/7/9/3?documentUUID=64da4833-2c9d-4e75-a80b-a68047772fd0; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822893_15823061_15823837_15823865:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6a6d64d113c376472b4cdc2302b74450
ToxValDB_ECHA_IUCLID NOAEL >=500 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbe6e4b0a7c65d2280ab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14290/7/6/2?documentUUID=64da4833-2c9d-4e75-a80b-a68047772fd0; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15849904:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c6d7b16e9efe0d175d12dd8f2c36a2f5
ToxValDB_ECHA_IUCLID NOEL =250 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc3af; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14290/7/6/2?documentUUID=64da4833-2c9d-4e75-a80b-a68047772fd0; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15849905:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3b050d14e0513565b3c1a5a47005beb1
ToxValDB_ECHA_IUCLID NOEL <62.5 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc3af; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14290/7/6/2?documentUUID=64da4833-2c9d-4e75-a80b-a68047772fd0; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15850889:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2775a0b6c72d4fc36c299f33067472fe
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =222 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA CEF (2015). Scientific Opinion on Flavouring Group Evaluation 78, Revision 2 (FGE.78Rev2): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic hydrocarbons evaluated by EFSA in FGE.25Rev3. doi:10.2903/j.efsa.2015.4067.; TITLE=Scientific Opinion on Flavouring Group Evaluation 78, Revision 2 (FGE.78Rev2): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic hydrocarbons evaluated by EFSA in FGE.25Rev3.; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2015.4067; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA_dup_-_15621538_15621539:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e54636669ca39bfac1a4c2efbc3f5b86
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =110.19 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630566:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_90e1549658406afc3721716156cc98bf
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier G3VG94Z26E UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"G3VG94Z26E"}
openFDA substances FDA UNII substance identifier G3VG94Z26E UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"G3VG94Z26E"}
openFDA substances FDA UNII substance identifier G3VG94Z26E UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"G3VG94Z26E"}
openFDA substances FDA UNII substance identifier G3VG94Z26E UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"G3VG94Z26E"}