NOAEL Studies Cosmetic Ingredient

Camphor Benzalkonium Methosulfate NOAEL Studies

INCI: CAMPHOR BENZALKONIUM METHOSULFATE

CAS: 52793-97-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 300 mg/kg bw/day rat oral 90 day Subchronic SCCP; O. Boutherin-Falson. Mexoryl SO – 13 week oral (gavage) toxicity study in the rat followed by a 4 week treatment-free period. MDS Pharma Services Study No. AA21484, 2005
COSMOS DB NOAEL 100 mg/kg bw/day rat oral 90 day Subchronic SCCP; O. Boutherin-Falson. Mexoryl SO – 13 week oral (gavage) toxicity study in the rat followed by a 4 week treatment-free period. MDS Pharma Services Study No. AA21484, 2005
SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.819 mg/kg rat oral 90-day dermal absorption (ref. 20), p.22
SCCS Opinion NOAEL =3 % - dermal - dermal absorption p.22
SCCS Opinion NOAEL =89.1 mg/kg bw rat oral 90-day dermal absorption p.22
SCCS Opinion NOAEL =300 mg/kg/day rat oral 13 weeks NOAEL study p.13
SCCS Opinion NOAEL =300 mg/kg/day rat oral 13 weeks genotoxicity p.14
SCCS Opinion NOAEL =1000 mg/kg/day rat - developmental developmental toxicity p.17
Regulatory source 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 300 mg/kg/day rat oral 13 weeks - p.13
Regulatory source dermal absorption =0.819 mg/kg rat oral 90-day dermal absorption p.22
Regulatory source dermal absorption 3 % - dermal - dermal absorption p.22
Regulatory source dermal absorption =89.1 mg/kg bw rat oral 90-day dermal absorption p.22
Regulatory source developmental toxicity 300 mg/kg/day guinea pig - 90-day developmental toxicity p.22
Regulatory source developmental toxicity 1000 mg/kg/day rat - developmental developmental toxicity p.17
Regulatory source developmental toxicity 1000 mg/kg/day guinea pig dermal 90-day developmental toxicity p.22
Regulatory source genotoxicity 300 mg/kg/day rat oral 13 weeks genotoxicity p.13