NOAEL Studies
Cosmetic Ingredient
Cannabidiol – Derived from Extract or Tincture or Resin of Cannabis NOAEL Studies
INCI: CANNABIDIOL (WITH COSING QUALIFIER: "DERIVED FROM EXTRACT OR TINCTURE OR RESIN OF CANNABIS")
CAS: 13956-29-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
FDA 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| FDA | NOAEL | =80 | mg/kg bw/day | rabbit (New Zealand White; male/female) | oral: gavage | GD7-19 | developmental toxicity teratogenicity | 33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z - DevelopmentalToxicityTeratogenicity - Oral (gavage) study of embryo-foetal development in the rabbit _GWTX1452 - af8cb309-1b41-4ca4-ae99-a5077a564320/3b986f49-e1e3-4118-8562-cb839a2e1dd2 - basis: other: |
| FDA | NOAEL | =400 | mg/kg bw/day | mouse (CD-1; male) | oral: gavage | 13 weeks | repeated dose toxicity oral | 33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z - RepeatedDoseToxicityOral - 13 week oral (gavage) administration range-finding study in the mouse_GWTX1688 - bf4737f5-7bab-4c82-94f5-f69f2d9f7f64/3b986f49-e1e3-4118-8562-cb839a2e1dd2 - basis: other: |
| FDA | NOAEL | =550 | mg/kg bw/day | mouse (CD-1; female) | oral: gavage | 13 weeks | repeated dose toxicity oral | 33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z - RepeatedDoseToxicityOral - 13 week oral (gavage) administration range-finding study in the mouse_GWTX1688 - bf4737f5-7bab-4c82-94f5-f69f2d9f7f64/3b986f49-e1e3-4118-8562-cb839a2e1dd2 - basis: other: |
| FDA | NOEL | <=25 | mg/kg bw/day | rat (Sprague-Dawley; male/female) | oral: gavage | GD 6-17 | developmental toxicity teratogenicity | 33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z - DevelopmentalToxicityTeratogenicity - Oral (gavage) developmental toxicity study in the rat_JJG0015 - 72237633-ef52-4b6c-8447-f10dfc5b54e8/3b986f49-e1e3-4118-8562-cb839a2e1dd2 - basis: mortality: no abnormal phenotype detected |
| FDA | NOEL | <=50 | mg/kg bw/day | rat (Wistar; male/female) | oral: feed | 104 weeks | carcinogenicity | 33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z - Carcinogenicity - 104 week oral (dietary) carcinogenicity study in the rat_JJG0003 - c1691e8d-6f9b-41b5-9f59-6dd5b91a97bf/3b986f49-e1e3-4118-8562-cb839a2e1dd2 - basis: histopathology: neoplastic |
| FDA | NOEL | <=80 | mg/kg bw/day | rat (Wistar; male/female) | oral: gavage | 26 weeks | repeated dose toxicity oral | 33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z - RepeatedDoseToxicityOral - 26 week oral (gavage) administration toxicity study in the rat followed by a 4 week treatment-free period_GWTX1429 - b9aa1847-fa1f-4712-95b5-15296d69f7d5/3b986f49-e1e3-4118-8562-cb839a2e1dd2 - basis: haematology: no abnormal phenotype detected |
| FDA | NOEL | <=100 | mg/kg bw/day | dog (Beagle; male/female) | oral: gavage | 39 weeks | repeated dose toxicity oral | 33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z - RepeatedDoseToxicityOral - 39 week oral (gavage) administration toxicity study in the dog followed by a 4 week treatment-free period_8302924 - 253eeaba-db83-4169-b9fb-15f7e39437ac/3b986f49-e1e3-4118-8562-cb839a2e1dd2 - basis: ophthalmological examination: no abnormal phenotype detected |
| FDA | NOEL | <=125 | mg/kg bw/day | rabbit (New Zealand White; male/female) | oral: gavage | GD7-19 | developmental toxicity teratogenicity | 33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z - DevelopmentalToxicityTeratogenicity - Oral (gavage) study of embryo-foetal development in the rabbit _GWTX1452 - af8cb309-1b41-4ca4-ae99-a5077a564320/3b986f49-e1e3-4118-8562-cb839a2e1dd2 - basis: clinical signs: no abnormal phenotype detected |
| FDA | NOEL | <=150 | mg/kg bw/day | rat (Wistar; male/female) | oral: gavage | 26 weeks | repeated dose toxicity oral | 33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z - RepeatedDoseToxicityOral - 26 week oral (gavage) administration toxicity study in the rat followed by a 4 week treatment-free period_8302923 - f4ad860a-ebd3-4cba-a882-0d48600c9f11/3b986f49-e1e3-4118-8562-cb839a2e1dd2 - basis: mortality: no abnormal phenotype detected |
| FDA | NOEL | <=250 | mg/kg bw/day | rat (Wistar; male/female) | oral: gavage | GD 6-17 | developmental toxicity teratogenicity | 33a0e61f-e087-4928-acb3-56a237369802_dossier.i6z - DevelopmentalToxicityTeratogenicity - Oral (gavage) study of embryo-foetal development in the rat _GWTX1454 - c965856d-5747-418e-ad00-2423f3f9fed2/3b986f49-e1e3-4118-8562-cb839a2e1dd2 - basis: mortality: no abnormal phenotype detected |
SCCS Opinion 38 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.19 | % | human | oral | - | NOAEL study | p.45 |
| SCCS Opinion | NOAEL | =1 | % | - | oral | - | NOAEL study | p.45 |
| SCCS Opinion | NOAEL | =1.3 | % | rat | - | 90-day | NOAEL study | p.42 |
| SCCS Opinion | NOAEL | =6 | % | - | oral | 90- day | NOAEL study | p.41 |
| SCCS Opinion | NOAEL | =6.25 | - | - | - | - | NOAEL study | p.45 |
| SCCS Opinion | NOAEL | =9 | mg/kg bw/day | rat | oral | 90-Day | repeated dose toxicity | p.33 |
| SCCS Opinion | NOAEL | =13 | mg/kg/day | rat | - | Developmental | developmental toxicity | p.37 |
| SCCS Opinion | NOAEL | =19 | mg/kg/day | rat | - | - | reproductive toxicity | p.35 |
| SCCS Opinion | NOAEL | =24.75 | mg/kg | rat | oral | 90-day | dermal absorption | p.44 |
| SCCS Opinion | NOAEL | =24.75 | - | - | - | - | NOAEL study | p.44 |
| SCCS Opinion | NOAEL | =25 | mg/kg bw/day | rat | oral | 90-day | repeated dose toxicity | p.31 |
| SCCS Opinion | NOAEL | =25 | mg/kg | rat | oral | 90-day | dermal absorption | p.44 |
| SCCS Opinion | NOAEL | =36 | - | - | - | - | NOAEL study | p.41 |
| SCCS Opinion | NOAEL | =41 | - | - | - | - | NOAEL study | p.41 |
| SCCS Opinion | NOAEL | =42 | - | - | - | - | NOAEL study | p.42 |
| SCCS Opinion | NOAEL | =44 | mg/kg bw/day | rat | oral | 90-day | repeated dose toxicity | p.31 |
| SCCS Opinion | NOAEL | =44 | - | - | oral | - | dermal absorption | p.44 |
| SCCS Opinion | NOAEL | =45 | - | - | oral | - | NOAEL study | p.45 |
| SCCS Opinion | NOAEL | =47 | mg/kg bw/d | rat | oral | 13-week | NOAEL study | p.34 |
| SCCS Opinion | NOAEL | =50 | mg/kg bw/day | rat | oral | 90-day | repeated dose toxicity | p.31 |
| SCCS Opinion | NOAEL | =72 | - | - | - | - | NOAEL study | p.41 |
| SCCS Opinion | NOAEL | =80 | mg/kg/day | rat | oral | developmental | developmental toxicity | p.36 |
| SCCS Opinion | NOAEL | >97 | % | - | oral | 2 months | NOAEL study | p.41 |
| SCCS Opinion | NOAEL | =99 | % | rat | oral | 28 days | NOAEL study | p.33 |
| SCCS Opinion | NOAEL | =100 | mg/kg/day | rat | oral | - | NOAEL study | p.34 |
| SCCS Opinion | NOAEL | =120 | - | - | - | - | NOAEL study | p.41 |
| SCCS Opinion | NOAEL | =140 | - | - | - | - | NOAEL study | p.41 |
| SCCS Opinion | NOAEL | =143 | mg/kg/day | rat | oral | 14 days | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =150 | mg/kg/day | rat | oral | Chronic | NOAEL study | p.34 |
| SCCS Opinion | NOAEL | =197.54 | mg/kg | rat | oral | 90-day | dermal absorption | p.44 |
| SCCS Opinion | NOAEL | =230 | - | - | - | - | NOAEL study | p.41 |
| SCCS Opinion | NOAEL | =238 | mg/kg | rat | oral | 28- day | NOAEL study | p.33 |
| SCCS Opinion | NOAEL | =250 | mg/kg | rat | oral | 90-Day | repeated dose toxicity | p.33 |
| SCCS Opinion | NOAEL | =250 | mg/kg/day | rat | oral | - | NOAEL study | p.36 |
| SCCS Opinion | NOAEL | =300 | mg/kg/day | mouse | - | 13-Week | NOAEL study | p.30 |
| SCCS Opinion | NOAEL | =360 | mg/kg bw/day | rat | oral | 90 days | NOAEL study | p.32 |
| SCCS Opinion | NOAEL | =400 | mg/kg/day | rat | oral | 90-Day | NOAEL study | p.30 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | rat | oral | 14-day | NOAEL study | p.32 |
ECHA 13 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | >=1 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca8fe4b0a7c65d222621; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=3b986f49-e1e3-4118-8562-cb839a2e1dd2; TOXICOLOGICAL_EFFECT=histopathology: non-neoplastic: abnormal diestrus|histopathology: non-neoplastic: abnormal metestrus; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835202_15835205_15838236:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4d440ce77770ca2f52a81c0a6b21d9bd |
| ECHA | LEL | >=10 | mg/kg bw/day | Dog | oral | chronic; 39 weeks | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca82e4b0a7c65d22227a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=3b986f49-e1e3-4118-8562-cb839a2e1dd2; TOXICOLOGICAL_EFFECT=body weight and weight gain: decreased susceptibility to weight gain|clinical biochemistry: increased circulating alkaline phosphatase level|clinical signs: abnormal feces composition|histopathology: non-neoplastic: liver; hypertrophy|organ weights and organ / body weight ratios: increased liver weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832241_15832242:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_79acaac5b6a8a535ae5979b8d4f91fa5 |
| ECHA | LEL | >=15 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca40e4b0a7c65d220ea5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=3b986f49-e1e3-4118-8562-cb839a2e1dd2; TOXICOLOGICAL_EFFECT=body weight and weight gain: decreased susceptibility to weight gain|clinical signs: convulsive seizures|mortality: abnormal survival; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831311_15831312_15835199_15835200_15835204_15838235_15838237:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b65234068268d4cd0b2db85df242fdaf |
| ECHA | LEL | >=40 | mg/kg bw/day | Rat | oral | chronic; 26 weeks | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb55e4b0a7c65d225c93; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=3b986f49-e1e3-4118-8562-cb839a2e1dd2; TOXICOLOGICAL_EFFECT=histopathology: non-neoplastic: increased alveolar macrophage number|histopathology: non-neoplastic: liver; hypertrophy|histopathology: non-neoplastic: thyroid gland hyperplasia|organ weights and organ / body weight ratios: increased liver weight; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15842008_15842009_15845905_15845906_15845907:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8496384915130ea7ee43dc92188cc4d4 |
| ECHA | LEL | >=50 | mg/kg bw/day | Dog | oral | chronic; 39 weeks | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca82e4b0a7c65d22227a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=3b986f49-e1e3-4118-8562-cb839a2e1dd2; TOXICOLOGICAL_EFFECT=body weight and weight gain: decreased body weight|clinical biochemistry: increased circulating alanine transaminase level; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832240_15832244:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_60c3969658b1ea06a76be870074870ae |
| ECHA | LEL | =150 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca40e4b0a7c65d220ea5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=3b986f49-e1e3-4118-8562-cb839a2e1dd2; TOXICOLOGICAL_EFFECT=clinical biochemistry: increased circulating aspartate transaminase level|clinical biochemistry: increased circulating cholesterol level; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835201_15835203:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a58447d6d8bc57e6b33efe7459c906d9 |
| ECHA | LEL | >=400 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc28e4b0a7c65d22944d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=3b986f49-e1e3-4118-8562-cb839a2e1dd2; TOXICOLOGICAL_EFFECT=clinical biochemistry: increased circulating alanine transaminase level|clinical biochemistry: increased circulating cholesterol level|clinical biochemistry: increased circulating globulin level|gross pathology: enlarged liver|histopathology: non-neoplastic: liver; hypertrophy|organ weights and organ / body weight ratios: increased liver weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|gross pathology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15842328_15842329:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f365da2c9611a5161252e298fa776019 |
| ECHA | LEL | >=550 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc28e4b0a7c65d22944d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=3b986f49-e1e3-4118-8562-cb839a2e1dd2; TOXICOLOGICAL_EFFECT=clinical biochemistry: increased circulating total protein level|gross pathology: granular kidney; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15842330_15842332_15842333_15842335_15842337:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_60b8359541a6a2ccee4918ae7e9f25f0 |
| ECHA | LEL | =625 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc28e4b0a7c65d22944d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=3b986f49-e1e3-4118-8562-cb839a2e1dd2; TOXICOLOGICAL_EFFECT=gross pathology: distended stomach; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15842330_15842332_15842333_15842335_15842337:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1f846257ab723ed5843b0c74fd081ba4 |
| ECHA | LEL | =700 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc28e4b0a7c65d22944d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=3b986f49-e1e3-4118-8562-cb839a2e1dd2; TOXICOLOGICAL_EFFECT=mortality: abnormal survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15842328_15842329:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0629c8f47e45a5a1afa30fb601f85d32 |
| ECHA | NOEL | <=80 | mg/kg bw/day | Rat | oral | chronic; 26 weeks | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb55e4b0a7c65d225c93; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=3b986f49-e1e3-4118-8562-cb839a2e1dd2; TOXICOLOGICAL_EFFECT=body weight and weight gain: no abnormal phenotype detected|clinical biochemistry: no abnormal phenotype detected|clinical signs: no abnormal phenotype detected|haematology: no abnormal phenotype detected|mortality: no abnormal phenotype detected|ophthalmological examination: no abnormal phenotype detected|urinalysis: no abnormal phenotype detected; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15842008_15842009_15845905_15845906_15845907:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a299351d508e85f264b3cc50850b7c24 |
| ECHA | NOEL | <=100 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc0ce4b0a7c65d228b43; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=3b986f49-e1e3-4118-8562-cb839a2e1dd2; TOXICOLOGICAL_EFFECT=body weight and weight gain: no abnormal phenotype detected|clinical biochemistry: no abnormal phenotype detected|clinical signs: no abnormal phenotype detected|haematology: no abnormal phenotype detected|mortality: no abnormal phenotype detected|ophthalmological examination: no abnormal phenotype detected|urinalysis: no abnormal phenotype detected; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831311_15831312_15835199_15835200_15835204_15838235_15838237:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1216957bf1ad5a6b29989775a1fb0d91 |
| ECHA | NOEL | <=150 | mg/kg bw/day | Rat | oral | chronic; 26 weeks | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cad7e4b0a7c65d223bec; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=3b986f49-e1e3-4118-8562-cb839a2e1dd2; TOXICOLOGICAL_EFFECT=body weight and weight gain: no abnormal phenotype detected|clinical signs: no abnormal phenotype detected|food consumption and compound intake: no abnormal phenotype detected|haematology: no abnormal phenotype detected|histopathology: non-neoplastic: no abnormal phenotype detected|mortality: no abnormal phenotype detected|ophthalmological examination: no abnormal phenotype detected|urinalysis: no abnormal phenotype detected; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15842008_15842009_15845905_15845906_15845907:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0a3edbb466144164a30ca16fbb58bf81 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 19GBJ60SN5 | UNII | - | - | - | chemical | - |