Moderate Cosmetic Ingredient NOAEL Data GHS Classified

Caproic Acid

INCI: CAPROIC ACID

CAS Number

142-62-1

Function

Perfuming; intermediate in ester synthesis

Safety Rating

MODERATE

Regulatory Status

🇪🇺 EU Status permitted

🇺🇸 US Status permitted

US Notes Must be calculated for CPSR if used as a standalone ingredient; NOAEL data available from OECD SIDS

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

not established

Dermal Absorption

moderate

Sensitization

none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Caproic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	2000 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
dose_tested	2000 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects

The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.

Long-term Exposure Effects

See Notes.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its aerosol and through the skin.

Expert Verdict

⚠️

Concern Level: Moderate

Regulatory Flags

fragrance-component epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Caproic Acid safe in cosmetics?

Corrosive in neat form with GHS H290, H314, H318 classifications. Must be used at concentrations where formulation pH and dilution mitigate corrosivity. Mandatory irritation testing for finished product. The EU classifies Caproic Acid as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is Caproic Acid allowed in the EU?

Caproic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Caproic Acid do in cosmetics?

Caproic Acid functions as: Perfuming; intermediate in ester synthesis. It is classified as a cosmetic ingredient in our database. CAS number: 142-62-1.

What is the Margin of Safety for Caproic Acid?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Caproic Acid?

The NOAEL (No Observed Adverse Effect Level) for Caproic Acid is 2000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Caproic Acid compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

Calculate Margin of Safety using SCCS methodology

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Heavy Metal Limits

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