Good Cosmetic Ingredient NOAEL Data

Capryloyl Glycine

INCI: CAPRYLOYL GLYCINE

CAS Number
14246-53-8
Function
Cleansing, emollient, hair conditioning, skin conditioning, surfactant, antiseborrheic, antiseptic, deodorant
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Generally considered safe; low skin irritation potential

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Capryloyl Glycine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 200 mg/kg bw/day oral rat oral REACH

Expert Verdict

Single sensitization case report documented; patch testing recommended for sensitive skin applications.

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Capryloyl Glycine safe in cosmetics?

Single sensitization case report documented; patch testing recommended for sensitive skin applications. The EU classifies Capryloyl Glycine as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is Capryloyl Glycine allowed in the EU?

Capryloyl Glycine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Capryloyl Glycine do in cosmetics?

Capryloyl Glycine functions as: Cleansing, emollient, hair conditioning, skin conditioning, surfactant, antiseborrheic, antiseptic, deodorant. It is classified as a cosmetic ingredient in our database. CAS number: 14246-53-8.

What is the Margin of Safety for Capryloyl Glycine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Capryloyl Glycine?

The NOAEL (No Observed Adverse Effect Level) for Capryloyl Glycine is 200 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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