Carbomer/Papain Crosspolymer

INCI: CARBOMER/PAPAIN CROSSPOLYMER

CAS Number
1203594-64-2
Function
Viscosity controlling, enzymatic exfoliation (papain digests keratin proteins for smoother skin)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted. Carbomers reviewed by CIR and found safe; papain has GRAS status for food

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Papain is a known sensitizer that can cause contact dermatitis and allergic reactions. Cross-linking to carbomer increases enzyme stability but does not eliminate sensitization potential.

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Carbomer/Papain Crosspolymer safe in cosmetics?

Papain is a known sensitizer that can cause contact dermatitis and allergic reactions. Cross-linking to carbomer increases enzyme stability but does not eliminate sensitization potential. The EU classifies Carbomer/Papain Crosspolymer as "permitted". Safety rating: MODERATE.

Is Carbomer/Papain Crosspolymer allowed in the EU?

Carbomer/Papain Crosspolymer EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Carbomer/Papain Crosspolymer do in cosmetics?

Carbomer/Papain Crosspolymer functions as: Viscosity controlling, enzymatic exfoliation (papain digests keratin proteins for smoother skin). It is classified as a cosmetic ingredient in our database. CAS number: 1203594-64-2.

What is the Margin of Safety for Carbomer/Papain Crosspolymer?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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