Is Carica Papaya Leaf Extract safe in cosmetics?
Carica Papaya Leaf Extract has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
Carica Papaya Leaf Extract
INCI: CARICA PAPAYA LEAF EXTRACT
Carica Papaya Leaf Extract (CAS 84012-30-6) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent (tonic); antioxidant; supports skin barrier;. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in food safety data.
View industrial chemical safety profile for CAS 84012-30-6 →
Function
Skin conditioning agent (tonic); antioxidant; supports skin barrier; photoprotective activity via suppression of UVB-induced MMP activation and ROS scavenging
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restrictions; not classified as OTC drug ingredient; leaf extract not separately reviewed for GRAS; CIR 2025 found insufficient data but no prohibition issued
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Carica Papaya Leaf Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Editorial summary
Preliminary editorial summary for Carica Papaya Leaf Extract — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
plant-derived
skin-conditioning
antioxidant
cir-insufficient-data-2025
latex-cross-reactivity-caution
tannin-irritation-potential
no-eu-restriction
no-us-restriction
ewg-limited-data
Chemical Function
Humectant
Softener and conditioner
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Papaya extract
Food Category
preservative
Frequently Asked Questions
Is Carica Papaya Leaf Extract allowed in the EU?
Carica Papaya Leaf Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Carica Papaya Leaf Extract do in cosmetics?
Carica Papaya Leaf Extract functions as: Skin conditioning agent (tonic); antioxidant; supports skin barrier; photoprotective activity via suppression of UVB-induced MMP activation and ROS scavenging. It is classified as a cosmetic ingredient in our database. CAS number: 84012-30-6.
Is Carica Papaya Leaf Extract used outside cosmetics?
Carica Papaya Leaf Extract also appears in food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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