NOAEL Studies
Cosmetic Ingredient
Carvacrol NOAEL Studies
INCI: CARVACROL
CAS: 499-75-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=b1058dde-3c09-433c-884f-6aa33c36bfde.i6z; document=4d945f7c-5cbf-4305-8d6c-1f125daa241f_b1058dde-3c09-433c-884f-6aa33c36bfde.i6d; document_key=4d945f7c-5cbf-4305-8d6c-1f125daa241f/b1058dde-3c09-433c-884f-6aa33c36bfde; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1996; basis=other:; key_result=false; entry_uuid=242f7ae8-e95f-4f81-8234-a99c31c65a4e |
| ECHA | NOAEL | 40 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=b1058dde-3c09-433c-884f-6aa33c36bfde.i6z; document=4d945f7c-5cbf-4305-8d6c-1f125daa241f_b1058dde-3c09-433c-884f-6aa33c36bfde.i6d; document_key=4d945f7c-5cbf-4305-8d6c-1f125daa241f/b1058dde-3c09-433c-884f-6aa33c36bfde; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1996; basis=body weight and weight gain; key_result=false; entry_uuid=ccf911ed-556d-4cc3-97e9-af96aecaa875 |
| ECHA | NOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=b1058dde-3c09-433c-884f-6aa33c36bfde.i6z; document=3fdb9411-3842-456e-85a2-5a0cfcb4c05e_b1058dde-3c09-433c-884f-6aa33c36bfde.i6d; document_key=3fdb9411-3842-456e-85a2-5a0cfcb4c05e/b1058dde-3c09-433c-884f-6aa33c36bfde; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; basis=clinical signs; key_result=false; entry_uuid=3062cb72-f970-468d-9e5f-c336d70550ea |
| ECHA | NOAEL | 400 | mg/kg bw/day | rat | oral: gavage | - | chronic toxicity: oral | dossier=b1058dde-3c09-433c-884f-6aa33c36bfde.i6z; document=86e86ee8-b12b-440a-a9a7-4fbb557aece7_b1058dde-3c09-433c-884f-6aa33c36bfde.i6d; document_key=86e86ee8-b12b-440a-a9a7-4fbb557aece7/b1058dde-3c09-433c-884f-6aa33c36bfde; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2006; basis=body weight and weight gain; key_result=false; entry_uuid=cfc1b194-575c-428b-b4d5-b37fba705ad1 |
| ECHA | NOEL | 8 | mg/kg bw/day | rat | oral: gavage | - | repeated dose toxicity: oral, other | dossier=b1058dde-3c09-433c-884f-6aa33c36bfde.i6z; document=7b5ef2c0-6b9b-4fcd-911b-17799f3df51d_b1058dde-3c09-433c-884f-6aa33c36bfde.i6d; document_key=7b5ef2c0-6b9b-4fcd-911b-17799f3df51d/b1058dde-3c09-433c-884f-6aa33c36bfde; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1996; basis=histopathology: non-neoplastic; key_result=false; entry_uuid=0fdb6baa-85d7-4247-99f0-899364764287 |
NTP ICE acute oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =810 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_6703; row=10857; data_type=In Vivo; mixture=Chemical; chemical_name=Isopropyl-o-cresol; preferred_name=Isopropyl-o-cresol; dtxsid=DTXSID6042074; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6042074; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=10840; RecordID=ARPathway2016_1240; DatasetName=ARPathway2016; DTXSID=DTXSID6042074; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6042074 |
NTP ICE skin irritation 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Viability (240 minutes) | 12.1 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4372; Record_ID=skin_irritation_invitro_1891; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6042074; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=12.1; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6042074 |
| NTP ICE skin irritation | Viability (240 minutes) | 12.5 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4371; Record_ID=skin_irritation_invitro_1892; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6042074; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=12.5; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6042074 |
| NTP ICE skin irritation | Viability (240 minutes) | 14.7 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4370; Record_ID=skin_irritation_invitro_1893; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6042074; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=14.7; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6042074 |
| NTP ICE skin irritation | Viability (3 minutes) | 48.9 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4367; Record_ID=skin_irritation_invitro_1891; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6042074; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=48.9; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6042074 |
| NTP ICE skin irritation | Viability (3 minutes) | 57.3 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4366; Record_ID=skin_irritation_invitro_1892; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6042074; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=57.3; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6042074 |
| NTP ICE skin irritation | Viability (3 minutes) | 73.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4364; Record_ID=skin_irritation_invitro_1893; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6042074; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=73.40; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6042074 |
| NTP ICE skin irritation | Viability (60 minutes) | 23.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4363; Record_ID=skin_irritation_invitro_1891; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6042074; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=23.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6042074 |
| NTP ICE skin irritation | Viability (60 minutes) | 26.5 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4362; Record_ID=skin_irritation_invitro_1892; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6042074; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=26.5; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6042074 |
| NTP ICE skin irritation | Viability (60 minutes) | 31.1 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4361; Record_ID=skin_irritation_invitro_1893; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6042074; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=31.1; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6042074 |
NTP ICE skin sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7513; Record_ID=skin_sensitization_invivo_1713; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6042074; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1977: report to RIFM|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80018-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6042074 |
| NTP ICE skin sensitization | Induction dose per skin area | 2700 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7511; Record_ID=skin_sensitization_invivo_1713; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6042074; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2700; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1977: report to RIFM|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80018-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6042074 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=7516; Record_ID=skin_sensitization_invivo_1713; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6042074; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1977: report to RIFM|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80018-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6042074 |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =4 | mg | Mouse | oral | acute; 1 days | acute | LONG_REF=J. Chem. Ecol.21(3): 263-271 Ahn,Y.J., S.B. Lee, T. Okubo, and M. Kim Antignawing Factor of Crude Oil Derived from Thujopsis dolabrata S. et Z. var. hondai Sawdust Against Mice 1995; TITLE=Antignawing Factor of Crude Oil Derived from Thujopsis dolabrata S. et Z. var. hondai Sawdust Against Mice; AUTHOR=Ahn,Y.J., S.B. Lee, T. Okubo, and M. Kim; DOI=10.1007/BF02036716; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102568; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Behavior: Bite or biting; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX:15605461:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9a7833a30cbbb3f44b51d30ac3f62794 |
EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | LEL | =2000 | mg/kg bw/day | Pig | oral | subchronic; 6 weeks | subchronic | LONG_REF=EFSA FEEDAP (2020). Safety and efficacy of Nimicoat (carvacrol) as a zootechnical additive for weaned piglets. doi:10.2903/j.efsa.2020.6070.; TITLE=Safety and efficacy of Nimicoat (carvacrol) as a zootechnical additive for weaned piglets; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2020.6070; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15621592:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8f9d55eedc595eb1a2d00a30a5fdfdb9 |
ToxValDB GESTIS DNEL 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =0.439 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630593_15630594_15630595:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_25e7efcba46d858d3b0e8240e623a947 |
| ToxValDB GESTIS DNEL | DNEL systemic | =9.87 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630593_15630594_15630595:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_162190e65b8d0cc6305f28f5a8fa56fa |
| ToxValDB GESTIS DNEL | DNEL systemic | =14.8 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630593_15630594_15630595:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_211acdba878f97f3898630bd6e54b933 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 9B1J4V995Q | UNII | - | - | - | chemical | - |