Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Carvacrol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 8 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 8 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 400 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 500 mg/kg bw/day | other | rat | oral | REACH |
| NOAEL | 500 mg/kg bw/day | other | rat | oral | REACH |
Sensitization Profile
Contact sensitization data for Carvacrol based on clinical patch test studies and IFRA standards.
Source: IVDK; literature review
Expert Verdict
Carvacrol is permitted in EU and US cosmetics as a fragrance/flavoring agent but carries significant sensitization risk due to H317 Skin Sensitizer 1 classification, requiring careful concentration control and risk assessment in formulations.
Regulatory Flags
Frequently Asked Questions
Is Carvacrol safe in cosmetics?
Carvacrol is permitted in EU and US cosmetics as a fragrance/flavoring agent but carries significant sensitization risk due to H317 Skin Sensitizer 1 classification, requiring careful concentration control and risk assessment in formulations. The EU classifies Carvacrol as "permitted". Safety rating: MODERATE. 7 toxicological study endpoint(s) are available in our database.
Is Carvacrol allowed in the EU?
Carvacrol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Carvacrol do in cosmetics?
Carvacrol functions as: Perfuming Agent, Antimicrobial, Antioxidant. It is classified as a Cosmetic Ingredient in our database. CAS number: 499-75-2.
What is the Margin of Safety for Carvacrol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Carvacrol?
The NOAEL (No Observed Adverse Effect Level) for Carvacrol is 8 mg/kg bw/day based on a oral study via oral route in rat. A total of 7 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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