Casein
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Casein. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 37000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 16500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 37500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 15000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 10000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 6330 mg/kg bw/day | oral | rabbit | Special Toxicology Study | COSMOS_DB |
| NOAEL | 9000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 32000 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| dose_tested | 37000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| dose_tested | 6330 mg/kg bw/day | oral | rabbit | Special Toxicology Study | COSMOS_DB |
Expert Verdict
Major allergen (milk protein) requiring declaration due to cross-reactivity risk for individuals with cow's milk allergy; not suitable for vegan-labeled products.
Regulatory Flags
Frequently Asked Questions
Is Casein safe in cosmetics?
Major allergen (milk protein) requiring declaration due to cross-reactivity risk for individuals with cow's milk allergy; not suitable for vegan-labeled products. The EU classifies Casein as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Casein allowed in the EU?
Casein EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Casein do in cosmetics?
Casein functions as: Anti-static agent; Emulsifier; Flavouring and nutrient; Processing aids not otherwise specified; Softener and conditioner; Surface modifier; Thickening agent. It is classified as a cosmetic ingredient in our database. CAS number: 9000-71-9.
What is the Margin of Safety for Casein?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Casein?
The NOAEL (No Observed Adverse Effect Level) for Casein is 37000 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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