Prunasin

INCI: PRUNASIN

CAS Number
99-18-3
Function
Skin conditioning (cyanogenic glycoside from *Prunus* species)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically listed for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

๐Ÿ”ด Cyanogenic glycoside โ€” enzymatic or acidic hydrolysis releases hydrogen cyanide (HCN). This is a significant toxicological concern. Present naturally in bitter almonds, cherry pits, and Prunus bark. Intentional use as an isolated cosmetic ingredient is highly inadvisable without rigorous safety assessment demonstrating that no HCN liberation occurs under use conditions.

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Concern Level: High

Regulatory Flags

natural-origin

Frequently Asked Questions

Is Prunasin safe in cosmetics?

๐Ÿ”ด Cyanogenic glycoside โ€” enzymatic or acidic hydrolysis releases hydrogen cyanide (HCN). This is a significant toxicological concern. Present naturally in bitter almonds, cherry pits, and Prunus bark. Intentional use as an isolated cosmetic ingredient is highly inadvisable without rigorous safety assessment demonstrating that no HCN liberation occurs under use conditions. The EU classifies Prunasin as "permitted". Safety rating: POOR.

Is Prunasin allowed in the EU?

Prunasin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Prunasin do in cosmetics?

Prunasin functions as: Skin conditioning (cyanogenic glycoside from *Prunus* species). It is classified as a cosmetic ingredient in our database. CAS number: 99-18-3.

What is the Margin of Safety for Prunasin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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