Centella Asiatica Extract

INCI: CENTELLA ASIATICA EXTRACT

CAS Number
84696-21-9
Function
active, wound-healing, anti-inflammatory, collagen-stimulating
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR Expert Panel assessed 9 Centella asiatica-derived ingredients โ€” all concluded safe in present practices of use and concentration, provided formulations are non-sensitizing. Cosmetic ingredient positioned as cosmetic/dermocosmetic in EU under Regulation (EC) 655/2013. Clinical data from 2024 two-center RCT confirms Centella asiatica repairing masks effective and safe as adjunctive rosacea treatment โ€” supports cosmetic efficacy claims without drug classification.

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Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Triterpene-rich extract (madecassoside, asiaticoside) that stimulates fibroblast proliferation and collagen synthesis. Double-blind study of 80 pregnant women demonstrated significantly fewer new stretch marks versus placebo, with strongest effects in women with pre-existing puberty striae. Among the best-evidenced topical ingredients for striae rubrae prevention. Well-tolerated with rare sensitization in individuals with Compositae allergy.

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Concern Level: Low

Regulatory Flags

active striae-prevention collagen-stimulating wound-healing anti-inflammatory pregnancy-safe double-blind-evidence

Frequently Asked Questions

Is Centella Asiatica Extract safe in cosmetics?

Triterpene-rich extract (madecassoside, asiaticoside) that stimulates fibroblast proliferation and collagen synthesis. Double-blind study of 80 pregnant women demonstrated significantly fewer new stretch marks versus placebo, with strongest effects in women with pre-existing puberty striae. Among the best-evidenced topical ingredients for striae rubrae prevention. Well-tolerated with rare sensitization in individuals with Compositae allergy. The EU classifies Centella Asiatica Extract as "permitted". Safety rating: GOOD.

Is Centella Asiatica Extract allowed in the EU?

Centella Asiatica Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Centella Asiatica Extract do in cosmetics?

Centella Asiatica Extract functions as: active, wound-healing, anti-inflammatory, collagen-stimulating. It is classified as a Active Ingredient in our database. CAS number: 84696-21-9.

What is the Margin of Safety for Centella Asiatica Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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