Is Tripeptide-1 safe in cosmetics?
Tripeptide-1 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Tripeptide-1
INCI: TRIPEPTIDE-1
Tripeptide-1 (CAS 72957-37-0) is a cosmetic active ingredient functioning as Antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 72957-37-0 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: S - IJT 42(Suppl. 3):32S
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tripeptide-1.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "72957-37-0", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction…
anti_aging
{"anti_aging_claim": "anti-wrinkle, firming, collagen-boosting", "mechanism_of_action": "Gly-His-Lys core, stimulates collagen synthesis", "target_skin_layer": "dermis", "collagen_stimulation": "Yes", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "12-18", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal":…
anti_pollution
{"cas_number": "72957-37-0", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibit…
concentration
{"min_concentration_pct": "0.001", "max_concentration_pct": "0.1", "typical_concentration_pct": "0.01", "product_type": "Serum", "function_at_concentration": "Collagen synthesis", "source": "Supplier TDS"}
ph_stability
{"optimal_ph_min": "5.5", "optimal_ph_max": "6.5", "stable_ph_min": "5.0", "stable_ph_max": "7.0", "degrades_above_ph": "7.5", "degrades_below_ph": "4.5", "ph_dependent_function": "Collagen synthesis", "formulation_note": "Standard peptide pH stability", "source": "Vivify 2026"}
self_tanning
{"cas_number": "72957-37-0", "ingredient_class": "tan_accelerator", "tanning_mechanism": "melanin_stimulation", "color_development_onset_hours": "96.0", "full_color_development_hours": "240", "color_duration_days": "14", "color_depth": "light", "undertone": "natural", "color_uniformity": "good", "fade_pattern": "even", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0…
sensory
{"silky": "liquid", "smooth, glides easily": "smooth, collagen-boosting", "dry-touch, non-greasy": "soft, firm", "instant": "fast", "low": "low", "w/o": "o/w", "very-high": "excellent", "no": "no", "yes": "no", "1.40": "1.35", "transparent": "transparent", "colorless": "colorless", "excellent": "excellent", "light": "light", "synthetic": "biotechnology"}
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "recommended", "sensitive_skin": "recommended", "combination_skin": "acceptable", "normal_skin": "recommended", "acne_prone": "acceptable", "rosacea": "recommended", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "recommended", "dehydrated": "recommended", "skin_benefit_primary": "anti-aging", "skin_benefit_secondary": "barrier-re…
Expert Verdict
Expert safety assessment and concern-level summary for Tripeptide-1.
Frequently Asked Questions
Is Tripeptide-1 allowed in the EU?
Tripeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tripeptide-1 do in cosmetics?
Tripeptide-1 functions as: Antioxidant. It is classified as a Active Ingredient in our database. CAS number: 72957-37-0.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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