NOAEL Studies
Cosmetic Ingredient
Chloroacetamide NOAEL Studies
INCI: CHLOROACETAMIDE
CAS: 79-07-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP ICE acute oral 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =306 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_10431; row=16196; data_type=In Vivo; mixture=Chemical; chemical_name=Chloroacetamide; preferred_name=Chloroacetamide; dtxsid=DTXSID9041570; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =138 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_10425; row=16197; data_type=In Vivo; mixture=Chemical; chemical_name=Chloroacetamide; preferred_name=Chloroacetamide; dtxsid=DTXSID9041570; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =275 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_10427; row=16198; data_type=In Vivo; mixture=Chemical; chemical_name=Chloroacetamide; preferred_name=Chloroacetamide; dtxsid=DTXSID9041570; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =70 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10423; row=16199; data_type=In Vivo; mixture=Chemical; chemical_name=Chloroacetamide; preferred_name=Chloroacetamide; dtxsid=DTXSID9041570; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =290 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_10429; row=16200; data_type=In Vivo; mixture=Chemical; chemical_name=Chloroacetamide; preferred_name=Chloroacetamide; dtxsid=DTXSID9041570; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570; source_file=acute_oral.xlsx |
NTP ICE skin sensitization 13 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 0.07979 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10365; Record_ID=skin_sensitization_invivo_2278; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041570; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.07979; Response_Unit=%; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 0.3661 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10382; Record_ID=skin_sensitization_invivo_2282; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041570; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.3661; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570 |
| NTP ICE skin sensitization | Concentration, one positive response | 0.01064 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10360; Record_ID=skin_sensitization_invivo_2278; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041570; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.01064; Response_Unit=%; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570 |
| NTP ICE skin sensitization | Concentration, one positive response | 0.03571 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10378; Record_ID=skin_sensitization_invivo_2282; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041570; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.03571; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570 |
| NTP ICE skin sensitization | Incidence of positive responses | 31.33 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10355; Record_ID=skin_sensitization_invivo_2278; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041570; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=31.33; Response_Unit=%; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570 |
| NTP ICE skin sensitization | Incidence of positive responses | 17.07 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10374; Record_ID=skin_sensitization_invivo_2282; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041570; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=17.07; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570 |
| NTP ICE skin sensitization | Induction dose per skin area | 625 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10353; Record_ID=skin_sensitization_invivo_2278; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041570; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=625; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570 |
| NTP ICE skin sensitization | Induction dose per skin area | 968.8 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10371; Record_ID=skin_sensitization_invivo_2282; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041570; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=968.8; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 99.73 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10367; Record_ID=skin_sensitization_invivo_2278; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041570; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=99.73; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 283.7 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10384; Record_ID=skin_sensitization_invivo_2282; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041570; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=283.7; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | 13.3 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10362; Record_ID=skin_sensitization_invivo_2278; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041570; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=13.3; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | 27.68 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10380; Record_ID=skin_sensitization_invivo_2282; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041570; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=27.68; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10369; Record_ID=skin_sensitization_invivo_2278; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9041570; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9041570 |
SCCS Opinion 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =3 | mg/kg bw/d | - | - | 13 weeks | reproductive toxicity | p.25 |
| SCCS Opinion | NOAEL | =10 | mg/kg bw/d | rabbit | intravenous | 30 days | NOAEL study | p.18 |
| SCCS Opinion | NOAEL | =10 | mg/kg bw/day | rat | oral | 90 d | NOAEL study | p.20 |
| SCCS Opinion | NOAEL | =16.6 | mg/kg bw/d | rat | oral | 30 day | repeated dose toxicity | p.38 |
| SCCS Opinion | NOAEL | =20 | - | rabbit | oral | 30 day | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =24 | mg/kg bw/d | - | - | - | reproductive toxicity | p.26 |
| SCCS Opinion | NOAEL | =35 | mg/kg | - | oral | 14d | repeated dose toxicity | p.20 |
| SCCS Opinion | NOAEL | =40 | % | rabbit | oral | 30 day | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =50 | mg/kg bw/d | - | dermal | - | dermal absorption | p.17 |
| SCCS Opinion | NOAEL | =50 | mg/kg bw/ d | rat | dermal | 30 day | NOAEL study | p.38 |
ECHA 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | =222 | mg/kg bw/day | Rat | oral | - | acute | GUIDELINE=OECD Guideline 401 (Acute Oral Toxicity); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11045/7/3/2?documentUUID=461f7260-88d8-4eb4-8b8b-0624a3527c9a; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15801878_15801880:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_025814bb6a0ccd03f0d59b309a15f22e |
| ECHA | LEL | =341 | mg/kg bw/day | Rat | oral | - | acute | GUIDELINE=OECD Guideline 401 (Acute Oral Toxicity); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11045/7/3/2?documentUUID=461f7260-88d8-4eb4-8b8b-0624a3527c9a; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15801878_15801880:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5e2829ccf1544fb717851a86b982695b |
| ECHA | LEL | =225 | mg/kg bw/day | Rat | oral | - | acute | GUIDELINE=OECD Guideline 401 (Acute Oral Toxicity); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11045/7/3/2?documentUUID=461f7260-88d8-4eb4-8b8b-0624a3527c9a; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15801881_15801883:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4d47c93ebcc3e534628b6850efe344c1 |
| ECHA | LEL | =417 | mg/kg bw/day | Rat | oral | - | acute | GUIDELINE=OECD Guideline 401 (Acute Oral Toxicity); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11045/7/3/2?documentUUID=461f7260-88d8-4eb4-8b8b-0624a3527c9a; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15801881_15801883:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d626a4d8e33a99efc48561afed828969 |
| ECHA | LEL | =221 | mg/kg bw/day | Rat | oral | - | acute | GUIDELINE=OECD Guideline 401 (Acute Oral Toxicity); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11045/7/3/2?documentUUID=461f7260-88d8-4eb4-8b8b-0624a3527c9a; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15801884_15801886:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7604b009d17089bcb2b394834045739f |
| ECHA | LEL | =382 | mg/kg bw/day | Rat | oral | - | acute | GUIDELINE=OECD Guideline 401 (Acute Oral Toxicity); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11045/7/3/2?documentUUID=461f7260-88d8-4eb4-8b8b-0624a3527c9a; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15801884_15801886:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_26411b85134eea70e75d508385fc8f75 |
| ECHA | NOAEL | =50 | mg/kg bw/day | Rat | dermal | subchronic; 3 months | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61dd6e4b096bca8777469; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11045/7/6/4?documentUUID=461f7260-88d8-4eb4-8b8b-0624a3527c9a; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15826317:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_22113edbdb5c97125df8b1ba7a45b7de |
| ECHA | NOAEL | =9.6 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc301; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11045/7/6/2?documentUUID=461f7260-88d8-4eb4-8b8b-0624a3527c9a; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832384_15832385:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dc0b361b10cfeac6b563a8d12e78d0d8 |
| ECHA | NOAEL | =10 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc301; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11045/7/6/2?documentUUID=461f7260-88d8-4eb4-8b8b-0624a3527c9a; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832384_15832385:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ac96918002647598b530ca8eead36683 |
| ECHA | NOAEL | <12.5 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc314; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11045/7/6/2?documentUUID=461f7260-88d8-4eb4-8b8b-0624a3527c9a; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15843912:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d032634864efbe514680db7af5afcf22 |
| ECHA | NOAEL | =100 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba114; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11045/7/9/2?documentUUID=461f7260-88d8-4eb4-8b8b-0624a3527c9a; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15855240:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2737490cbc5e9012536f0f964ef163e1 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =0.705 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630645:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_261148ab85480879b857dcd9b3a234de |
Regulatory source 22 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 10 | mg/kg bw/d | rabbit | intravenous | 30 days | - | p.18 |
| Regulatory source | - | 10 | mg/kg bw/day | rat | oral | 90 d | - | p.20 |
| Regulatory source | - | 10 | mg/kg bw/d | rat | oral | 90 d | - | p.20 |
| Regulatory source | - | 10 | mg/kg bw/d | rat | oral | 13 week | - | p.37 |
| Regulatory source | - | 20 | - | rabbit | oral | 30 day | - | p.16 |
| Regulatory source | - | 40 | % | rabbit | oral | 30 day | - | p.16 |
| Regulatory source | - | 50 | mg/kg bw/ d | rat | dermal | 30 day | - | p.38 |
| Regulatory source | dermal absorption | 50 | mg/kg bw/d | - | dermal | - | dermal absorption | p.17 |
| Regulatory source | dermal absorption | 50 | mg/kg bw/d | rabbit | dermal | - | dermal absorption | p.17 |
| Regulatory source | genotoxicity | 10 | mg/kg bw/d | - | oral | - | genotoxicity | p.40 |
| Regulatory source | genotoxicity | 50 | mg/kg bw/d | - | oral | - | genotoxicity | p.40 |
| Regulatory source | repeated dose toxicity | 10 | mg/kg bw/d | rat | oral | Sub-chronic | repeated dose toxicity | p.18 |
| Regulatory source | repeated dose toxicity | 10 | mg /kg bw/d | rat | oral | subchronic | repeated dose toxicity | p.21 |
| Regulatory source | repeated dose toxicity | 10 | mg/kg bw/d | rat | oral | subchronic | repeated dose toxicity | p.21 |
| Regulatory source | repeated dose toxicity | =16.6 | mg/kg bw/d | rat | oral | 30 day | repeated dose toxicity | p.38 |
| Regulatory source | repeated dose toxicity | 35 | mg/kg | - | oral | 14d | repeated dose toxicity | p.20 |
| Regulatory source | repeated dose toxicity | 50 | mg/kg bw/d | rat | oral | subchronic | repeated dose toxicity | p.21 |
| Regulatory source | repeated dose toxicity | =50 | mg/kg bw/d | rat | oral | 30 day | repeated dose toxicity | p.38 |
| Regulatory source | reproductive toxicity | 3 | mg/kg bw/d | - | - | 13 weeks | reproductive toxicity | p.25 |
| Regulatory source | reproductive toxicity | 3 | mg/kg bw/d | rat | oral | - | reproductive toxicity | p.27 |
| Regulatory source | reproductive toxicity | 3 | mg/kg bw/d | mouse | oral | - | reproductive toxicity | p.40 |
| Regulatory source | reproductive toxicity | 24 | mg/kg bw/d | - | - | - | reproductive toxicity | p.26 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 2R97846T1L | UNII | - | - | - | chemical | - |