Also known as: Acetamide, 2-chloro-, 2-Chloracetamide, BRN 0878191, 2-Chloroethanamide, EINECS 201-174-2 (+1 more)
INCI: CHLOROACETAMIDE
Chloroacetamide (CAS 79-07-2) is a cosmetic cosmetic ingredient functioning as Former preservative. NOAEL 12.5 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 79-07-2 →
Chloroacetamide is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H317, H319, H361, H361f, H315, H360F).
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Chloroacetamide.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for Chloroacetamide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =3 mg/kg bw/d | - | - | reproductive toxicity | SCCS Opinion |
| NOAEL | =3 mg/kg bw/d | - | - | reproductive toxicity | SCCS Opinion |
| NOAEL | =3 mg/kg bw/d | - | - | reproductive toxicity | SCCS Opinion |
| NOAEL | =3 mg/kg bw/d | - | - | reproductive toxicity | SCCS Opinion |
| NOAEL | =10 mg/kg bw/d | intravenous | rabbit | NOAEL study | SCCS Opinion |
| NOAEL | =10 mg/kg bw/day | oral | rat | NOAEL study | SCCS Opinion |
| NOAEL | =10 mg/kg bw/d | intravenous | rabbit | NOAEL study | SCCS Opinion |
| NOAEL | =10 mg/kg bw/day | oral | rat | NOAEL study | SCCS Opinion |
| NOAEL | =10 mg/kg bw/d | intravenous | rabbit | NOAEL study | SCCS Opinion |
| NOAEL | =10 mg/kg bw/day | oral | rat | NOAEL study | SCCS Opinion |
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Pre-calculated NOAEL → SED → MoS audit trail for Chloroacetamide across SCCS product categories, with measured dermal absorption where available.
Contact sensitization data for Chloroacetamide based on clinical patch test studies and IFRA standards.
Source: ESSCA; IVDK; NACDG
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Inserted via ATP: CLP00
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: HPPT: [28] Jordan Jr WP and King SE (1977): https://doi.org/10.1111/j.1600-0536.1977.tb03582.x
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | 625 | - | - |
| HRIPT | - | 0 | 968.75 | - | - |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | permitted_preservative | 0.3 | all cosmetics |
| BR | banned | - | - |
| CA | banned | - | - |
| ASEAN | permitted_preservative | 0.3% | All products |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 56.0% | - | - | SCCS/0053 |
2 property records from structured ingredient metadata.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Expert safety assessment and concern-level summary for Chloroacetamide.
Public NOAEL study rows linked to Chloroacetamide by CAS number or substance name.
Units vary across source rows: mg/kg bw/d, mg/kg bw/day, mg/kg
| Absorption % | Method | Vehicle |
|---|---|---|
| 56.0% | - | - |
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Chloroacetamide has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
Chloroacetamide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
Chloroacetamide functions as: Former preservative. It is classified as a cosmetic ingredient in our database. CAS number: 79-07-2.
The NOAEL (No Observed Adverse Effect Level) for Chloroacetamide is =3 mg/kg bw/d based on a reproductive toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS Opinion.
Chloroacetamide carries a GHS signal word of "DANGER". Hazard statements: Toxic if swallowed Causes mild skin irritation Causes eye irritation May cause allergic skin reaction Suspected of damaging fertility or the unborn child Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Chloroacetamide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Chloroacetamide is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H317, H319, H361, H361f, H315, H360F).
Check Chloroacetamide compliance across multiple jurisdictions:
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