Chloroacetamide
INCI: CHLOROACETAMIDE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Chloroacetamide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 50 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | 10 mg/kg bw/day | intravenous | rabbit | other | REACH |
| NOAEL | 50 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOAEL | 10 mg/kg bw/day | 2400 | rabbit | other | REACH |
| NOAEL | 12.5 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 12.5 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Sensitization Profile
Contact sensitization data for Chloroacetamide based on clinical patch test studies and IFRA standards.
Source: ESSCA; IVDK; NACDG
Expert Verdict
CMR Category 2 substance with carcinogenic, mutagenic, and reprotoxic potential; banned in EU; strong contact allergen with formaldehyde releaser potential.
Regulatory Flags
Frequently Asked Questions
Is Chloroacetamide safe in cosmetics?
CMR Category 2 substance with carcinogenic, mutagenic, and reprotoxic potential; banned in EU; strong contact allergen with formaldehyde releaser potential. The EU classifies Chloroacetamide as "prohibited". Safety rating: POOR. 7 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is Chloroacetamide allowed in the EU?
Chloroacetamide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Chloroacetamide do in cosmetics?
Chloroacetamide functions as: Former preservative. It is classified as a cosmetic ingredient in our database. CAS number: 79-07-2.
What is the Margin of Safety for Chloroacetamide?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Chloroacetamide?
The NOAEL (No Observed Adverse Effect Level) for Chloroacetamide is 100 mg/kg bw/day based on a oral study via oral route in rat. A total of 7 study endpoints are available. Source: REACH.
Is Chloroacetamide classified as hazardous under GHS?
Chloroacetamide carries a GHS signal word of "DANGER". Hazard statements: Toxic if swallowed Causes mild skin irritation Causes eye irritation May cause allergic skin reaction Suspected of damaging fertility or the unborn child Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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