NOAEL Studies Cosmetic Ingredient

Choline Chloride NOAEL Studies

CAS: 67-48-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 10 mg/kg bw/day dog oral 25 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 700 mg/kg bw/day rat oral 20 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1000 mg/kg bw/day rat oral 25 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1200 mg/kg bw/day mouse oral 30 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1350 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP ICE acute oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =3400 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9214; row=6879; data_type=In Vivo; mixture=Chemical; chemical_name=Choline chloride; preferred_name=2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride; dtxsid=DTXSID4020325; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020325; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4020325; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =6640 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9215; row=6878; data_type=In Vivo; mixture=Chemical; chemical_name=Choline chloride; preferred_name=2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride; dtxsid=DTXSID4020325; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020325; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4020325; source_file=acute_oral.xlsx
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =194.54 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630712:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_df8782034ad0f1db48822fa8c268fa94
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 45I14D8O27 UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H14NO.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"45I14D8O27"}
openFDA substances FDA UNII substance identifier 45I14D8O27 UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H14NO.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"45I14D8O27"}
openFDA substances FDA UNII substance identifier 45I14D8O27 UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H14NO.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"45I14D8O27"}
openFDA substances FDA UNII substance identifier 45I14D8O27 UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H14NO.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"45I14D8O27"}